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In the Federal Republic of Germany today there are 6 to 8 million hypertensive patients. Of them, 3 to 4 million show organic cardiac manifestations of hypertension. Of all deaths occurring before the age of 65, 40% are attributable to hypertension, and the total mortality from hypertension is about 25%. The high cardiac morbidity and mortality potential of the risk factor 'hyper tension' lies in the development of cardiac hypertrophy, heart failure and coronary artery disease. In addition, hypertensive patients are predisposed to develop secondary cardiac diseases. The aim of the present study was to analyse the myocardial function and coronary haemodynamics in essential hypertension, i. e. the most common type of pressure load imposed on the human heart. Consequently, the function and mode of operation of the hypertensive heart are described - a type of hypertrophy of the human heart which to date has almost been ignored in pathophysiology and diagnostics. On the basis of the findings, conclusions are drawn for the differential diagnosis and therapy of the hypertensive heart accompanied by hypertrophy, heart failure and coronary artery disease. This work was supported by Deutsche Forschungsgemeinschaft. The support in translating this manuscript by Petra Froschen, Christine Ebel and Cornelia Leisse is gratefully acknowledged.
566 kr
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Der arterielle Bluthochdruck ist die häufigste Form der Druckbelastung des linken Ventrikels. Der Hochdruck selbst gilt als einer der wichtigsten Risikofaktoren der koronaren Herzkrankheit. In dieser 3. Neuauflage werden erstmals systematische Untersuchungen zur Hypertrophieregression des Ventrikelmyokards sowie zur Beeinflussung der hypertensiven Mikroangiopathie dargestellt. Darüber hinaus analysiert der Autor die Probleme der Inzidenz von Herzrhythmusstörungen bei hypertensiver Herzhypertrophie, der diastolischen Eigenschaften des linken Ventrikels, der stummen Myokardischämie sowie der Rheologie des Koronarkreislaufs. Die Neuauflage berücksichtigt die Umsetzung der neuesten wissenschaftlichen Erkenntnisse in der Therapie des Hochdruckherzens.
566 kr
Skickas inom 10-15 vardagar
1 094 kr
Skickas inom 10-15 vardagar
In the last decade, ACE inhibitors have become a cornerstone of cardiovascular drug therapy. Beneficial effects in patients with hypertension, heart failure, and post myocardial infarction have been established in large clinical trials. In parallel, ex- perimental research has shifted the interest from the immediate homeostatic function of the circulating renin-angiotensin-system to the multiple paracrine functions of local tissue renin-angiotensin-systems, including hypertrophy, hyperplasia, athe- oenesis, and vasomotion. . It was the aim or a symposium held in Hamburg, October 22-24, 1992, to bring together an international panel of experimental and clinical scientists and to discuss the most recent findings on the role of angiotensin and associated mediators in car- diovascular adaptation and disease, with a particular emphasis on the treatment of such disease by ACE inhibitors. The meeting and this publication were generously supported by Astra Chemicals. H. Grobecker G. Heusch B. E. Strauer Contents Foreword...V Introduction Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart Dzau, V. J...1Myocardial Perfusion Angiotensin, ACE-inhibitors and endothelial control of vasomotor tone Luscher, T. F...15 Local and neurohumoral control of coronary blood flow Krajcar, M. , G. Heusch...25 ACE-inhibitors in coronary artery disease? Vogt, M. , W. Matz, B. E. Strauer ...43 Myocardial Hypertrophy Molecular mechanisms of cardiac gene expression Nadal-Ginard, B. , V. Mahdavi ...65 Myocardial perfusion dependent and independent mechanisms of regional myocardial dysfunction in hypertrophy Vatner, S. F. , L. Hittinger ...