Bruce J West – författare

This exceptional book is concerned with the application of fractals and chaos, as well as other concepts from nonlinear dynamics to biomedical phenomena. Herein we seek to communicate the excitement being experienced by scientists upon making application of these concepts within the life sciences. Mathematical concepts are introduced using biomedical data sets and the phenomena being explained take precedence over the mathematics.In this new edition what has withstood the test of time has been updated and modernized; speculations that were not borne out have been expunged and the breakthroughs that have occurred in the intervening years are emphasized. The book provides a comprehensive overview of a nascent theory of medicine, including a new chapter on the theory of complex networks as they pertain to medicine.

This book is not a text devoted to a pedagogical presentation of a specialized topic nor is it a monograph focused on the author's area of research. It accomplishes both these things while providing a rationale for why the reader ought to be interested in learning about fractional calculus. This book is for researchers who has heard about many of these scientifically exotic activities, but could not see how they fit into their own scientific interests, or how they could be made compatible with the way they understand science. It is also for beginners who have not yet decided where their scientific talents could be most productively applied. The book provides insight into the long-term direction of science and show how to develop the skills necessary to successfully do research in the twenty-first century.

You can never step in the same river twice, goes the old adage of philosophy. An observation on the transitory nature of fluids in motion, this saying also describes the endless variations researchers face when studying human movement. Understanding these biodynamics-why the wirewalker doesn't fall-requires a grasp of the constant fluctuations and fine tunings which maintain balance in the complex, fluid system of human locomotion.Taking a comprehensive approach to the phenomenon of locomotion, Biodynamics: Why the Wirewalker Doesn't Fall integrates physical laws and principles with concepts of fractals, chaos, and randomness. In so doing, it formulates a description of both the large-scale, smooth aspects of locomotion and the more minute, randomized mechanisms of this physiological process.Ideal for beginners in this subject, Biodynamics provides an elegant explanation without assuming the reader's understanding of complex physical principles or mathematical equations. Chapter topics include:* Dimensions, measurement, and scaling* Mechanics and dynamics* Biometrics* Conservation of momentum* Biomechanics* Bioelectricity* Bioenergetics* Fluid mechanics and dynamics* Data analysis* BiostatisticsPacked with problem sets, examples, and original line drawings, Biodynamics is an invaluable text for advanced undergraduates, graduate students, and instructors in medicine, biology, physiology, biophysics, and bioengineering.

This book is the first of its kind on fractional calculus (FC), dedicated to advocating for FC in STEM education and research.Fractional calculus is increasingly used today, but there remains a core population of skeptics regarding the utility of this "new" calculus. This book is intended for those who are skeptical about the need for fractional calculus to describe dynamic complex networks and must be convinced of its use on a case-by-case basis. It is a one-stop resource to rapidly read and replace the appropriate skepticism with new knowledge. It offers compelling reasons from the perspectives of the physical, social, and life sciences as to why fractional calculus is needed when addressing the complexity of an underlying STEM phenomenon. The six chapters are accompanied by useful and essential appendices and chapter-end references. Each includes new (fractional-order) ways of thinking about statistics, complexity dynamics, and what constitutes a solution to a complexity science problem.The book will appeal to students and researchers in all STEM-related fields, such as engineering, physics, biology and biomedicine, climate change, big data, and machine learning. It is also suitable for general readers interested in these fields.

On the Fractal Language of Medicine bridges a very clear gap among the knowledge gained over the last 20 years in the physical and life sciences on network theory, organ synchronicity and communication, the understanding of fractal signatures in health and disease and the importance of fractional calculus in integrating these concepts.The authors opine that the field of medicine has not appreciated this hard-won knowledge and has suffered greatly as a result. This book addresses this perceived deficiency by introducing medical researchers, clinicians, residents, first-year medical students and members of allied fields to the work of the so-called hard sciences. It seeks to facilitate effective communication between empiricists and theorists by making interdisciplinary efforts to explain complex mathematical concepts to physicians and, equally important, to elucidate complex medical concepts to physicists or mathematicians.This book will be of great interest to medical students, professionals and academics, as well as students and researchers of applied mathematics, especially those interested in fractional calculus and fractals.

This second volume of the multi-volume Fractional Calculus for Skeptics explores the concept of “roughness” and its applications in complex systems. It demonstrates how fractional calculus offers valuable insights into modeling real-world phenomena that traditional calculus struggles to address.Building on the first volume's foundational work advocating a fractal/fractional calculus paradigm shift, this volume offers an in-depth exploration of the concept of “roughness,” drawing parallels to what Benoît B. Mandelbrot originally intended to call the “Science of Roughness.” The book introduces the novel concept of “body roughness” and demonstrates its practical applications through two case studies of “roughness-informed rehabilitation therapy” with closed-loop control systems. One study involves non-invasive, 40-Hz gamma-frequency sensory stimulation for Alzheimer's disease, and the other involves biologically variable ventilation using roughness-informed, closed-loop control. The four chapters are complemented by valuable appendices and essential chapter-end references, as well as insightful “take-home messages.”This book will appeal to students, researchers, and professionals in STEM fields, including engineering, physics, biology, biomedicine, control engineering, rehabilitation, big data, and machine learning.

This book is not a text devoted to a pedagogical presentation of a specialized topic nor is it a monograph focused on the author's area of research. It accomplishes both these things while providing a rationale for why the reader ought to be interested in learning about fractional calculus. This book is for researchers who has heard about many of these scientifically exotic activities, but could not see how they fit into their own scientific interests, or how they could be made compatible with the way they understand science. It is also for beginners who have not yet decided where their scientific talents could be most productively applied. The book provides insight into the long-term direction of science and show how to develop the skills necessary to successfully do research in the twenty-first century.

This book describes a new strategy for rehabilitation from injury and/or disease using Crucial Event Therapy. Recent studies have shown that individuals can recuperate more rapidly from surgery and other invasive procedures intended to correct the negative effects of disease or injury through the use of life support systems that operate at the body's natural biofrequencies. The same observation has been clinically shown to reverse the degenerative effects of neurodegenerative diseases such as Parkinson’s and Alzheimer's Disease.Crucial Event Therapy describes medicine as the operational control of the functions of the human body treated as a network-of-networks, with 1/f-variable crucial events coding the dynamic states of health and disease through information flow within a network and information exchange between biomedical networks. A new way of thinking based on the statistics of Cortical Events is presented and the relevant literature is suitably referenced. This is anideal book for biophysicists and data scientists seeking to understand the connection of complexity measures for the study of consciousness with the clinical aspects of designing a rehabilitation strategy.

Complexity increases with increasing system size in everything from organisms to organizations. The nonlinear dependence of a system’s functionality on its size, by means of an allometry relation, is argued to be a consequence of their joint dependency on complexity (information). In turn, complexity is proven to be the source of allometry and to provide a new kind of force entailed by a system‘s information gradient. Based on first principles, the scaling behavior of the probability density function is determined by the exact solution to a set of fractional differential equations. The resulting lowest order moments in system size and functionality gives rise to the empirical allometry relations. Taking examples from various topics in nature, the book is of interest to researchers in applied mathematics, as well as, investigators in the natural, social, physical and life sciences. ContentsComplexityEmpirical allometryStatistics, scaling and simulationAllometry theoriesStrange kineticsFractional probability calculus

Networks of Echoes: Imitation, Innovation and Invisible Leaders is a mathematically rigorous and data rich book on a fascinating area of the science and engineering of social webs. There are hundreds of complex network phenomena whose statistical properties are described by inverse power laws. The phenomena of interest are not arcane events that we encounter only fleetingly, but are events that dominate our lives. We examine how this intermittent statistical behavior intertwines itself with what appears to be the organized activity of social groups. The book is structured as answers to a sequence of questions such as: How are decisions reached in elections and boardrooms? How is the stability of a society undermined by zealots and committed minorities and how is that stability re-established? Can we learn to answer such questions about human behavior by studying the way flocks of birds retain their formation when eluding a predator? These questions and others are answered using a generic model of a complex dynamic network—one whose global behavior is determined by a symmetric interaction among individuals based on social imitation. The complexity of the network is manifest in time series resulting from self-organized critical dynamics that have divergent first and second moments, are non-stationary, non-ergodic and non-Poisson. How phase transitions in the network dynamics influence such activity as decision making is a fascinating story and provides a context for introducing many of the mathematical ideas necessary for understanding complex networks in general. The decision making model (DMM) is selected to emphasize that there are features of complex webs that supersede specific mechanisms and need to be understood from a general perspective. This insightful overview of recent tools and their uses may serve as an introduction and curriculum guide in related courses.

Networks of Echoes: Imitation, Innovation and Invisible Leaders is a mathematically rigorous and data rich book on a fascinating area of the science and engineering of social webs. There are hundreds of complex network phenomena whose statistical properties are described by inverse power laws. The phenomena of interest are not arcane events that we encounter only fleetingly, but are events that dominate our lives. We examine how this intermittent statistical behavior intertwines itself with what appears to be the organized activity of social groups. The book is structured as answers to a sequence of questions such as: How are decisions reached in elections and boardrooms? How is the stability of a society undermined by zealots and committed minorities and how is that stability re-established? Can we learn to answer such questions about human behavior by studying the way flocks of birds retain their formation when eluding a predator? These questions and others are answered using a generic model of a complex dynamic network—one whose global behavior is determined by a symmetric interaction among individuals based on social imitation. The complexity of the network is manifest in time series resulting from self-organized critical dynamics that have divergent first and second moments, are non-stationary, non-ergodic and non-Poisson. How phase transitions in the network dynamics influence such activity as decision making is a fascinating story and provides a context for introducing many of the mathematical ideas necessary for understanding complex networks in general. The decision making model (DMM) is selected to emphasize that there are features of complex webs that supersede specific mechanisms and need to be understood from a general perspective. This insightful overview of recent tools and their uses may serve as an introduction and curriculum guide in related courses.

One of my favorite quotes is from a letter of Charles Darwin (1887): "I have long discovered that geologists never read each other's works, and that the only object in writing a book is proof of earnestness, and that you do not form your opinions without undergoing labour of some kind. " It is not clear if this private opinion of Darwin was one that he held to be absolutely true, or was one of those opinions that, as with most of us, coincides with our "bad days," but is replaced with a more optimistic view on our "good days. " I hold the sense of the statement to be true in general, but not with regard to scientists never reading each other's work. Even if that were true however, the present essay. would still have been written as a proof of earnestness. This essay outlines my personal view of how nonlinear mathematics may be of value in formulating models outside the physical sciences. This perspective has developed over a number of years during which time I have repeatedly been amazed at how an "accepted" model would fail to faithfully characterize the full range of avail­ able data because of its implicit or explicit dependence on linear concepts. This essay is intended to demonstrate how linear ideas have come to dominate and therefore limit a scientist's ability to understand any given class of phenomena.

This book discusses the application of the concepts of fractals and chaos to biomedical phenomena. In particular, it argues against the outdated notion of homeostasis; using biomedical data sets and modern mathematical concepts, the author attempts to convince the reader that life is at least a homeodynamic process with multiple states — each being capable of survival. Although relying heavily on the new mathematical ideas, the author has attempted to make the book self-contained. The mathematics is developed in a biological context and mathematical formulation for its own sake is avoided. In this book, the phenomena to be explained motivate the mathematical development rather than the other way round.

This book discusses the application of the concepts of fractals and chaos to biomedical phenomena. In particular, it argues against the outdated notion of homeostasis; using biomedical data sets and modern mathematical concepts, the author attempts to convince the reader that life is at least a homeodynamic process with multiple states — each being capable of survival. Although relying heavily on the new mathematical ideas, the author has attempted to make the book self-contained. The mathematics is developed in a biological context and mathematical formulation for its own sake is avoided. In this book, the phenomena to be explained motivate the mathematical development rather than the other way round.

A nonsimple (complex) system indicates a mix of crucial and non-crucial events, with very different statistical properties. It is the crucial events that determine the efficiency of information exchange between complex networks. For a large class of nonsimple systems, crucial events determine catastrophic failures - from heart attacks to stock market crashes.This interesting book outlines a data processing technique that separates the effects of the crucial from those of the non-crucial events in nonsimple time series extracted from physical, social and living systems. Adopting an informal conversational style, without sacrificing the clarity necessary to explain, the contents will lead the reader through concepts such as fractals, complexity and randomness, self-organized criticality, fractional-order differential equations of motion, and crucial events, always with an eye to helping to interpret what mathematics usually does in the development of new scientific knowledge.Both researchers and novitiate will find Crucial Events useful in learning more about the science of nonsimplicity.

Where Medicine Went Wrong explores how the idea of an average value has been misapplied to medical phenomena, distorted understanding and lead to flawed medical decisions. Through new insights into the science of complexity, traditional physiology is replaced with fractal physiology, in which variability is more indicative of health than is an average. The capricious nature of physiological systems is made conceptually manageable by smoothing over fluctuations and thinking in terms of averages. But these variations in such aspects as heart rate, breathing and walking are much more susceptible to the early influence of disease than are averages.It may be useful to quote from the late Stephen Jay Gould's book Full House on the errant nature of averages: “… our culture encodes a strong bias either to neglect or ignore variation. We tend to focus instead on measures of central tendency, and as a result we make some terrible mistakes, often with considerable practical import.” Dr West has quantified this observation and make it useful for the diagnosis of disease.

This book provides a lens through which modern society is shown to depend on complex networks for its stability. One way to achieve this understanding is through the development of a new kind of science, one that is not explicitly dependent on the traditional disciplines of biology, economics, physics, sociology and so on; a science of networks. This text reviews, in non-mathematical language, what we know about the development of science in the twenty-first century and how that knowledge influences our world. In addition, it distinguishes the two-tiered science of the twentieth century, based on experiment and theory (data and knowledge) from the three-tiered science of experiment, computation and theory (data, information and knowledge) of the twenty-first century in everything from psychophysics to climate change.This book is unique in that it addresses two parallel lines of argument. The first line is general and intended for a lay audience, but one that is scientifically sophisticated, explaining how the paradigm of science has been changed to accommodate the computer and large-scale computation. The second line of argument addresses what some consider the seminal scientific problem of climate change. The authors show how a misunderstanding of the change in the scientific paradigm has led to a misunderstanding of complex phenomena in general, and the causes of global warming in particular.

This invaluable book captures the proceedings of a workshop that brought together a group of distinguished scientists from a variety of disciplines to discuss how networking influences decision making. The individual lectures interconnect psychological testing, the modeling of neuron networks and brain dynamics to the transport of information within and between complex networks. Of particular importance was the introduction of a new principle that governs how complex networks talk to one another — the Principle of Complexity Management (PCM). PCM establishes that the transfer of information from a stimulating complex network to a responding complex network is determined by how the complexity indices of the two networks are related. The response runs the gamut from being independent of the perturbation to being completely dominated by it, depending on the complexity mismatch.

This is the second volume in a series intended to give clear expositions of the applications of the new techniques developed to understand nonlinear phenomena in the life sciences. The first paper by West, Mackey and Chen is methodological in nature and reviews how to distinguish between noise in biomedical data sets and irregularities generated by deterministic dynamical equations. The second paper by Hock, Schöner, Balz, Eastman and Voss addresses the problem of pattern formation and pattern change in the vision system. The authors emphasize the experimental correspondence between quantifiable perceptual phenomena and certain features of nonlinear dynamical systems theory.The paper by Chay focuses on modeling strategies for biological phenomena that manifest strong nonlinear behavior. Biological rhythms and electrical bursting phenomena are discussed in detail, and certain apparently random processes are shown to be describable by chaos. The final paper is an attempt by Nicolis and Katsikas to use nonlinear dynamics systems theory to develop a general theory of linguistics. The concepts of information and pattern recognition are used in concert with that of a dynamic attractor to argue for the general properties of a cognitive processor.

The authors describe mostly in non-technical language the development of a new scientific paradigm based on nonlinear deterministic dynamics and fractal geometry. The concepts from these two mathematical disciplines are interwoven with data from the physical, social and life sciences. In this way rather sophisticated mathematical concepts are made accessible through experimental data from various disciplines, and the formalism is relegated to appendices. It is shown that the complexity of natural and social phenomena invariably lead to inverse power law distributions, both in terms of probabilities and spectra. This book tries to show how to think differently about familiar phenomena, such as why the bell-shape curve ought not to be used in teaching or in the characterization of such complex phenomena as intelligence.

This book concerns the development of a theory of complex phenomena; using such concepts as fractals; chaos; and fractional derivatives; but; most important; the idea of an allometric control process is developed. In summary the theory attempts to explain why the distribution in the intensity of wars is the same as the relative frequency of the number of words used in languages and the number of species evolved over time from one or a few remote ancestors. The theory also describes the similarity in the variability of the number of births to teens in Texas to the number of sexual partners in homosexual liaisons. The data in both of the aforementioned categories are shown to have long-term memory; and it is this memory that also gives rise to inverse power laws in such physiological phenomena as the interbeat interval distribution of the human heart; the interstride interval distribution in the human gait; and memory in DNA sequences.