C.G. Gebelein - Böcker

This book is derived from a Symposium held at the 190th National American Chemical Society Meeting, which was held in the Fall of 1985, in Chicago, and was sponsored by the Division of Polymeric Materials: Science & Engineering. This Symposium was, in turn, a follow-up on an earlier one held in Houston, TX, in the Spring of 1980, which was pub­ lished as the book ·Biomedical and Dental Applications of Polymers· [Plenum Press, New York, 1981]. In that earlier book, our opening Preface passage quoted King David, ·1 will praise Thee; for I am fearfully and made . •• • (Psalm 139:14). As we noted five years ago, sickness wonderfully of many types does occur in our wonderfully made bodies, but much human suffering can be aided by biomedical polymers. That earlier book con­ sidered much of the fantastic progress that had been made in biomedical polymers during the previous quarter century and brought many of these topics up to date. That Symposium, and book, noted that much help was available for the varied afflictions and problems that sometimes beset, and upset, our God-given bodies, and the promise of new and important advances was held out as a shining ray of hope amidst the gloom of sickness and affliction. The present volume is an update on the advances that have occurred since the 1981 book and sets the stage for even greater advances in the future.

The term biotechnology has emerged on the contemporary scene fairly recently, but the basic concept of utilizing natural materials, either directly or in modified versions, dates back to antiquity.

Polymers continue to show almost amazing versatility. We have always known that polymers could be used for trinkets, toys and dishes. Now, however, we are no longer surprised to encounter these adaptable mate­ rials in almost every place we look. We find them in our cars, tools, electronic devices, building materials, etc. The use of polymeric mate­ rials in medicine is also well documented in previous books by one of the Editors (Gebelein) and by others. Likewise, the use of polymeric mate­ rials in pharmaceutical applications, especially in controlled release systems, is also well established. Nevertheless, the use of these ubiquitous chemicals is far less ob­ vious in the field of cosmetics, although modern cosmetic preparations rely heavily on polymers and this trend is certain to increase. This book brings together much of the basic information on polymers in cosmetics and compares this usage with similar applications in pharmaceutical and medical applications. Cosmetics, like medicine and pharmacy, dates back to antiquity. We can find uses of perfumes, balms and ointments in various old books, such as the Bible. For example, the use of ointments and balms is noted more than thirty eight times, and perfumes and related materials are cited at least twenty nine times in the Bible.

Some have predicted that the coming several decades will be the decades of "biotechnology," wherein cancer, birth defects, life span increases, cosmetics, biodegradation, oil spills and exploration, solid waste disposal, and almost every aspect of our material life will be affected by this new area of science. There will also be an extension of emphasis on giant molecules: DNA, enzymes, polysaccharides, lignins, proteins, hemoglobin, and many others. Biotechnology has been defined in various ways. In one sense, this field is older than human history and references to the human use of biotechnology-derived materials can be found in the oldest human writings, such as the Bible. In this book, biotechnology refers to the direct usage of naturally occurring materials or their uses as a feedstock, including the associated biological activities and applications of these materials. Bioactive polymers, on the other hand, are polymers which exert some type of activity on living organisms. These polymers are used in agriculture, controlled release systems, medicine and many other areas. The papers in this book describe polymers which essentially combine features of biotechnology and bioactivity.

The term biomimetic is comparatively new on the chemical scene, but the concept has been utilized by chemists for many years. Furthermore, the basic idea of making a synthetic material that can imitate the func­ tions of natural materials probably could be traced back into antiquity. From the dawn of creation, people have probably attempted to duplicate or modify the activities of the natural world. (One can even find allusions to these attempts in the Bible; e. g. , Genesis 30. ) The term "mimetic" means to imitate or mimic. The word "mimic" means to copy closely, or to imitate accurately. Biomimetic, which has not yet entered most dictionaries, means to imitate or mimic some specific bio­ logical function. Usually, the objective of biomimetics is to form some useful material without the need of utilizing living systems. In a simi­ lar manner, the term biomimetic polymers means creating synthetic poly­ mers which imitate the activity of natural bioactive polymers. This is a major advance in polymer chemistry because the natural bioactive polymers are the basis of life itself. Thus, biomimetic polymers imitate the life process in many ways. This present volume delineates some of the recent progress being made in this vast field of biomimetic polymers. Chemists have been making biomimetic polymers for more than fifty years, although this term wasn't used in the early investigations.

This book is derived from a Symposium held at the 190th National American Chemical Society Meeting, which was held in the Fall of 1985, in Chicago, and was sponsored by the Division of Polymeric Materials: Science & Engineering. This Symposium was, in turn, a follow-up on an earlier one held in Houston, TX, in the Spring of 1980, which was pub­ lished as the book ·Biomedical and Dental Applications of Polymers· [Plenum Press, New York, 1981]. In that earlier book, our opening Preface passage quoted King David, ·1 will praise Thee; for I am fearfully and made . •• • (Psalm 139:14). As we noted five years ago, sickness wonderfully of many types does occur in our wonderfully made bodies, but much human suffering can be aided by biomedical polymers. That earlier book con­ sidered much of the fantastic progress that had been made in biomedical polymers during the previous quarter century and brought many of these topics up to date. That Symposium, and book, noted that much help was available for the varied afflictions and problems that sometimes beset, and upset, our God-given bodies, and the promise of new and important advances was held out as a shining ray of hope amidst the gloom of sickness and affliction. The present volume is an update on the advances that have occurred since the 1981 book and sets the stage for even greater advances in the future.

The term biotechnology has emerged on the contemporary scene fairly recently, but the basic concept of utilizing natural materials, either directly or in modified versions, dates back to antiquity. If we search the ancient literature, such as the Bible, we find hundreds of examples wherein people employed, or modified, natural materials for a variety of important uses. As far back as the days of Noah we find pitch, a natural material, being used as a caulk. Clothing was made from animal skins and the products of several plants. Today, we would consider these things as important biotechnological developments. Likewise, the human use of polymeric materials also has a long his­ tory. In fact, many of the original materials used by mankind were poly­ mers derived from nature, such as wood, flax, cotton, wool and animal skins, which were used for shelter and clothing. In recent years, however, the concept of biotechnology has taken on a new and renewed role in our society. This is due to a combination of factors, including an increased interest in environmental concerns and the desire to break free from the stranglehold that petrochemicals have placed on our society. If we can manufacture some of our polymers from renewable resources, then we can expect to prepare them for many more years into the future than we might if we could only depend on the petro­ chemical resources.

Polymers continue to show almost amazing versatility. We have always known that polymers could be used for trinkets, toys and dishes. Now, however, we are no longer surprised to encounter these adaptable mate­ rials in almost every place we look. We find them in our cars, tools, electronic devices, building materials, etc. The use of polymeric mate­ rials in medicine is also well documented in previous books by one of the Editors (Gebelein) and by others. Likewise, the use of polymeric mate­ rials in pharmaceutical applications, especially in controlled release systems, is also well established. Nevertheless, the use of these ubiquitous chemicals is far less ob­ vious in the field of cosmetics, although modern cosmetic preparations rely heavily on polymers and this trend is certain to increase. This book brings together much of the basic information on polymers in cosmetics and compares this usage with similar applications in pharmaceutical and medical applications. Cosmetics, like medicine and pharmacy, dates back to antiquity. We can find uses of perfumes, balms and ointments in various old books, such as the Bible. For example, the use of ointments and balms is noted more than thirty eight times, and perfumes and related materials are cited at least twenty nine times in the Bible.