Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso''s pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging.Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso''s sophisticated experiments were to neuroscience what surgeon William Beaumont''s in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso''s rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author''s remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso''s life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso''s work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso''s pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.

Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso''s pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging.Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso''s sophisticated experiments were to neuroscience what surgeon William Beaumont''s in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso''s rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author''s remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso''s life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso''s work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso''s pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.

Easy to read and to use, this A-to-Z mini-encyclopedia covers the most important medical innovations of the last 200 years.Medical innovation is an extremely important topic—and one to which relatively little study has been devoted. This volume is designed to introduce readers to the history and development of key advances in the science and practice of medicine. It explores issues in medical history and provides perspective on contemporary scientific research and innovation. It also provides a backdrop against which to evaluate current headlines, such as the discoveries of live samples of smallpox virus in an unused storage room at the National Institutes of Health (NIH) and incidents of bubonic plague in China and Colorado.Although the entries in this single-volume resource describe how each innovation works, this is not intended as a technical text. Instead, the focus is on the context in which each innovation was developed and on its lasting importance in the field of medicine. Through these fascinating accounts, readers will be able to trace the evolution and legacy of key innovations and to see how other sectors of society—such as industry and the military—have affected and been affected by advances in the field of medicine.

Easy to read and to use, this A-to-Z mini-encyclopedia covers the most important medical innovations of the last 200 years.Medical innovation is an extremely important topic—and one to which relatively little study has been devoted. This volume is designed to introduce readers to the history and development of key advances in the science and practice of medicine. It explores issues in medical history and provides perspective on contemporary scientific research and innovation. It also provides a backdrop against which to evaluate current headlines, such as the discoveries of live samples of smallpox virus in an unused storage room at the National Institutes of Health (NIH) and incidents of bubonic plague in China and Colorado.Although the entries in this single-volume resource describe how each innovation works, this is not intended as a technical text. Instead, the focus is on the context in which each innovation was developed and on its lasting importance in the field of medicine. Through these fascinating accounts, readers will be able to trace the evolution and legacy of key innovations and to see how other sectors of society—such as industry and the military—have affected and been affected by advances in the field of medicine.

Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso''s pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging.Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso''s sophisticated experiments were to neuroscience what surgeon William Beaumont''s in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso''s rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author''s remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso''s life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso''s work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso''s pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.

Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso''s pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging.Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso''s sophisticated experiments were to neuroscience what surgeon William Beaumont''s in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso''s rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author''s remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso''s life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso''s work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso''s pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public.

Easy to read and to use, this A-to-Z mini-encyclopedia covers the most important medical innovations of the last 200 years.Medical innovation is an extremely important topic—and one to which relatively little study has been devoted. This volume is designed to introduce readers to the history and development of key advances in the science and practice of medicine. It explores issues in medical history and provides perspective on contemporary scientific research and innovation. It also provides a backdrop against which to evaluate current headlines, such as the discoveries of live samples of smallpox virus in an unused storage room at the National Institutes of Health (NIH) and incidents of bubonic plague in China and Colorado.Although the entries in this single-volume resource describe how each innovation works, this is not intended as a technical text. Instead, the focus is on the context in which each innovation was developed and on its lasting importance in the field of medicine. Through these fascinating accounts, readers will be able to trace the evolution and legacy of key innovations and to see how other sectors of society—such as industry and the military—have affected and been affected by advances in the field of medicine.

Easy to read and to use, this A-to-Z mini-encyclopedia covers the most important medical innovations of the last 200 years.Medical innovation is an extremely important topic—and one to which relatively little study has been devoted. This volume is designed to introduce readers to the history and development of key advances in the science and practice of medicine. It explores issues in medical history and provides perspective on contemporary scientific research and innovation. It also provides a backdrop against which to evaluate current headlines, such as the discoveries of live samples of smallpox virus in an unused storage room at the National Institutes of Health (NIH) and incidents of bubonic plague in China and Colorado.Although the entries in this single-volume resource describe how each innovation works, this is not intended as a technical text. Instead, the focus is on the context in which each innovation was developed and on its lasting importance in the field of medicine. Through these fascinating accounts, readers will be able to trace the evolution and legacy of key innovations and to see how other sectors of society—such as industry and the military—have affected and been affected by advances in the field of medicine.