This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts – both basic scientists and clinicians – the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.- Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions- Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation- Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

The Handbook of Clinical Neurology Vol 102: Neuro-Ophthalmology provides a comprehensive discussion of the field of neuro-ophthalmology. The book is organized into four sections. Section 1 lays out fundamental concepts of the visual system and eye movements. It discusses the anatomy and physiology of the afferent visual system and the ocular motor system, and the neuro-ophthalmological examination. Section 2 deals with disorders of the afferent visual system, covering retinal disorders; abnormalities of the optic disc; lesions of the optic nerve; the optic chiasm; disorders of the optic tract, radiation, and occipital lobe; disorders of higher visual processing; and rehabilitative techniques.

Section 3 discusses ocular motor abnormalities, including infranuclear ocular motor disorders; nuclear, internuclear, and supranuclear ocular motor disorders; nystagmus and saccadic intrusions; disorders of higher gaze control; and normal and abnormal lid function. Section 4 covers disorders of the pupil; neuro-ophthalmology of orbital disease; and functional neuro-ophthalmology. This book will be useful to early-stage physicians, as well as specialists interested in the latest developments in neuro-ophthalmology.

A comprehensive resource that explores the innovative methods used to understand the visual system An in-depth study of how the brain processes vision, and the role certain functions such as eye movement play in visual diagnosis and memory Clinical and laboratory methods of evaluation that are perfect for physicians and specialists in any stage of practice

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean B�ttner-Ennever. With 87 contributions from international experts - both basic scientists and clinicians - the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesionsOrganizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentationArticles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

The Handbook of Clinical Neurology Vol 102: Neuro-Ophthalmology provides a comprehensive discussion of the field of neuro-ophthalmology. The book is organized into four sections. Section 1 lays out fundamental concepts of the visual system and eye movements. It discusses the anatomy and physiology of the afferent visual system and the ocular motor system, and the neuro-ophthalmological examination. Section 2 deals with disorders of the afferent visual system, covering retinal disorders; abnormalities of the optic disc; lesions of the optic nerve; the optic chiasm; disorders of the optic tract, radiation, and occipital lobe; disorders of higher visual processing; and rehabilitative techniques.Section 3 discusses ocular motor abnormalities, including infranuclear ocular motor disorders; nuclear, internuclear, and supranuclear ocular motor disorders; nystagmus and saccadic intrusions; disorders of higher gaze control; and normal and abnormal lid function. Section 4 covers disorders of the pupil; neuro-ophthalmology of orbital disease; and functional neuro-ophthalmology. This book will be useful to early-stage physicians, as well as specialists interested in the latest developments in neuro-ophthalmology.- A comprehensive resource that explores the innovative methods used to understand the visual system- An in-depth study of how the brain processes vision, and the role certain functions such as eye movement play in visual diagnosis and memory- Clinical and laboratory methods of evaluation that are perfect for physicians and specialists in any stage of practice

Hughlings Jackson, the noted English neurologist, fathered many ideas that today still underlie our understanding of common clinical phenomena. This is a reappraisal of Jackson''s work, both within its historical framework and in light of modern concepts of neurology. The approach is new, combining historical, clinical and basic scientific information in one synthesis on the organization and function of the nervous system. The concept of levels of function is addressed, specifically with regard to areas of brain function; and the hierarchical strategy is considered as part of the current concept of a distributed system of neurons. Clinicians and scientists alike will find much food for thought in this modern treatise of Jacksonian concepts.

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts – both basic scientists and clinicians – the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.- Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions- Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation- Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

The Handbook of Clinical Neurology Vol 102: Neuro-Ophthalmology provides a comprehensive discussion of the field of neuro-ophthalmology. The book is organized into four sections. Section 1 lays out fundamental concepts of the visual system and eye movements. It discusses the anatomy and physiology of the afferent visual system and the ocular motor system, and the neuro-ophthalmological examination. Section 2 deals with disorders of the afferent visual system, covering retinal disorders; abnormalities of the optic disc; lesions of the optic nerve; the optic chiasm; disorders of the optic tract, radiation, and occipital lobe; disorders of higher visual processing; and rehabilitative techniques.

Section 3 discusses ocular motor abnormalities, including infranuclear ocular motor disorders; nuclear, internuclear, and supranuclear ocular motor disorders; nystagmus and saccadic intrusions; disorders of higher gaze control; and normal and abnormal lid function. Section 4 covers disorders of the pupil; neuro-ophthalmology of orbital disease; and functional neuro-ophthalmology. This book will be useful to early-stage physicians, as well as specialists interested in the latest developments in neuro-ophthalmology.

A comprehensive resource that explores the innovative methods used to understand the visual system An in-depth study of how the brain processes vision, and the role certain functions such as eye movement play in visual diagnosis and memory Clinical and laboratory methods of evaluation that are perfect for physicians and specialists in any stage of practice

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean B�ttner-Ennever. With 87 contributions from international experts - both basic scientists and clinicians - the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesionsOrganizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentationArticles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

The Handbook of Clinical Neurology Vol 102: Neuro-Ophthalmology provides a comprehensive discussion of the field of neuro-ophthalmology. The book is organized into four sections. Section 1 lays out fundamental concepts of the visual system and eye movements. It discusses the anatomy and physiology of the afferent visual system and the ocular motor system, and the neuro-ophthalmological examination. Section 2 deals with disorders of the afferent visual system, covering retinal disorders; abnormalities of the optic disc; lesions of the optic nerve; the optic chiasm; disorders of the optic tract, radiation, and occipital lobe; disorders of higher visual processing; and rehabilitative techniques.Section 3 discusses ocular motor abnormalities, including infranuclear ocular motor disorders; nuclear, internuclear, and supranuclear ocular motor disorders; nystagmus and saccadic intrusions; disorders of higher gaze control; and normal and abnormal lid function. Section 4 covers disorders of the pupil; neuro-ophthalmology of orbital disease; and functional neuro-ophthalmology. This book will be useful to early-stage physicians, as well as specialists interested in the latest developments in neuro-ophthalmology.- A comprehensive resource that explores the innovative methods used to understand the visual system- An in-depth study of how the brain processes vision, and the role certain functions such as eye movement play in visual diagnosis and memory- Clinical and laboratory methods of evaluation that are perfect for physicians and specialists in any stage of practice

Hughlings Jackson, the noted English neurologist, fathered many ideas that today still underlie our understanding of common clinical phenomena. This is a reappraisal of Jackson''s work, both within its historical framework and in light of modern concepts of neurology. The approach is new, combining historical, clinical and basic scientific information in one synthesis on the organization and function of the nervous system. The concept of levels of function is addressed, specifically with regard to areas of brain function; and the hierarchical strategy is considered as part of the current concept of a distributed system of neurons. Clinicians and scientists alike will find much food for thought in this modern treatise of Jacksonian concepts.