R. John Leigh – författare

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts – both basic scientists and clinicians – the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.* Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions* Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation* Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

This volume brings together work from leading researchers in the fields of developmental disorders of binocular vision, strabismus, and both infantile and acquired forms of nystagmus. It contains four sections. The first section, Basic Concepts of Stable Vision and Gaze, deals with psychophysical aspects of infantile forms of nystagmus and the relative contributions of extraocular proprioception and efference (corollary discharge). It also contains an accessible review of current notions of spatial and temporal visual functions and spatial constancy in infantile nystagmus syndrome and latent nystagmus. The second section, New Models and Techniques for Studying Gaze Stability, reviews animal and development models for strabismus, amblyopia, and nystagmus. It also contains novel optical methods for managing the visual consequences of nystagmus and a study of the potential ill effects of video displays on children''s response to near viewing. The third section, New Therapies for Congenital Nystagmus, presents basic genetic studies and clinical trials of drug and surgical treatment of those patients with infantile forms of nystagmus. The final section,General Aspects of Normal and Abnormal Gaze Control, pulls together a range of contributions dealing with normal gaze control, infantile nystagmus, and acquired disorders of eye movements, including new treatment measures. This book will be a valuable resource for all scientists and practitioners interested in developmental disorders of vision.

This volume brings together work from leading researchers in the fields of developmental disorders of binocular vision, strabismus, and both infantile and acquired forms of nystagmus. It contains four sections. The first section, Basic Concepts of Stable Vision and Gaze, deals with psychophysical aspects of infantile forms of nystagmus and the relative contributions of extraocular proprioception and efference (corollary discharge). It also contains an accessible review of current notions of spatial and temporal visual functions and spatial constancy in infantile nystagmus syndrome and latent nystagmus. The second section, New Models and Techniques for Studying Gaze Stability, reviews animal and development models for strabismus, amblyopia, and nystagmus. It also contains novel optical methods for managing the visual consequences of nystagmus and a study of the potential ill effects of video displays on children's response to near viewing. The third section, New Therapies for Congenital Nystagmus, presents basic genetic studies and clinical trials of drug and surgical treatment of those patients with infantile forms of nystagmus. The final section,General Aspects of Normal and Abnormal Gaze Control, pulls together a range of contributions dealing with normal gaze control, infantile nystagmus, and acquired disorders of eye movements, including new treatment measures. This book will be a valuable resource for all scientists and practitioners interested in developmental disorders of vision.

This volume brings together work from leading researchers in the fields of developmental disorders of binocular vision, strabismus, and both infantile and acquired forms of nystagmus. It contains four sections. The first section, Basic Concepts of Stable Vision and Gaze, deals with psychophysical aspects of infantile forms of nystagmus and the relative contributions of extraocular proprioception and efference (corollary discharge). It also contains an accessible review of current notions of spatial and temporal visual functions and spatial constancy in infantile nystagmus syndrome and latent nystagmus. The second section, New Models and Techniques for Studying Gaze Stability, reviews animal and development models for strabismus, amblyopia, and nystagmus. It also contains novel optical methods for managing the visual consequences of nystagmus and a study of the potential ill effects of video displays on children''s response to near viewing. The third section, New Therapies for Congenital Nystagmus, presents basic genetic studies and clinical trials of drug and surgical treatment of those patients with infantile forms of nystagmus. The final section,General Aspects of Normal and Abnormal Gaze Control, pulls together a range of contributions dealing with normal gaze control, infantile nystagmus, and acquired disorders of eye movements, including new treatment measures. This book will be a valuable resource for all scientists and practitioners interested in developmental disorders of vision.

This new edition of Leigh and Zee's Neurology of Eye Movements is available as an enhanced edition for the first time. Your purchase of the print version includes access to the online version via Oxford Medicine Online. By activating your unique access code, you can discover more than 200 videos, view and enlarge nearly 250 high resolution images, and annotate the work for future personal reference.The Neurology of Eye Movements, edition 5 has two interrelated parts. The first comprises a modern synthesis of the anatomical, physiological, and pharmacological substrate for eye movements, including current views on the reflexive and voluntary control of gaze. This synthesis is based on electrophysiological and inactivation studies in macaque, and behavioural studies in humans that incorporate functional imaging and transcranial magnetic stimulation (TMS) in normals, and clinicopathological studies in patients with neurological, visual, or vestibular disorders. Sophisticated experimental paradigms have been applied to both species to explore aspects of cognition, memory, volition, and reward. This large body of research has demonstrated the power of eye movements as experimental tools. The second part of the book applies this synthesis to the clinical and laboratory evaluation of patients with abnormal eye movements due to a broad range of disorders - from muscular dystrophy, and genetic disorders, to dementia, including visual and vestibular conditions. By placing links to figures, tables, boxes, and videos, a synthesis of basic research and clinical findings is provided, that may shed new light on disease processes and provide insights on normal brain function.

The Handbook of Clinical Neurology Vol 102: Neuro-Ophthalmology provides a comprehensive discussion of the field of neuro-ophthalmology. The book is organized into four sections. Section 1 lays out fundamental concepts of the visual system and eye movements. It discusses the anatomy and physiology of the afferent visual system and the ocular motor system, and the neuro-ophthalmological examination. Section 2 deals with disorders of the afferent visual system, covering retinal disorders; abnormalities of the optic disc; lesions of the optic nerve; the optic chiasm; disorders of the optic tract, radiation, and occipital lobe; disorders of higher visual processing; and rehabilitative techniques.

Section 3 discusses ocular motor abnormalities, including infranuclear ocular motor disorders; nuclear, internuclear, and supranuclear ocular motor disorders; nystagmus and saccadic intrusions; disorders of higher gaze control; and normal and abnormal lid function. Section 4 covers disorders of the pupil; neuro-ophthalmology of orbital disease; and functional neuro-ophthalmology. This book will be useful to early-stage physicians, as well as specialists interested in the latest developments in neuro-ophthalmology.

A comprehensive resource that explores the innovative methods used to understand the visual system An in-depth study of how the brain processes vision, and the role certain functions such as eye movement play in visual diagnosis and memory Clinical and laboratory methods of evaluation that are perfect for physicians and specialists in any stage of practice

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean B�ttner-Ennever. With 87 contributions from international experts - both basic scientists and clinicians - the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesionsOrganizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentationArticles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic. Ocular Motor Plant and Gaze Stabilization Mechanisms, Volume 248, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Mathematical modeling in clinical and basic motor neuroscience, The math of medicine - the computational lessons learned from the human disease, Mathematical models - an extension of the clinician's mind, From differential equation to linear control systems: the study of the VOR, Closed lop and nonlinear systems, State-space equations and learning, Integrators and optimal control, and much more.

Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Includes the latest information on mathematical modeling in motor neuroscience

Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease, Volume 249, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Sequential Bayesian updating, Maps and Sensorimotor Transformations for Eye-Head Gaze Shifts: Role of the Midbrain Superior Colliculus, Modeling Gaze Position-Dependent Opsoclonus, Eye Position-Dependent Opsoclonus in Mild Traumatic Brain Injury, Saccades in Parkinson's disease -- hypometric, slow, and maladaptive, Brainstem Neural Circuits for Fixation and Generation of Saccadic Eye Movements, and much more.

Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Includes the latest information on mathematical modeling in motor neuroscience