Cristian Falup-Pecurariu - Böcker

Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson's disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction.

Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson's disease Each chapter covers a specific autonomic symptom: classification, assessment, treatment Presents the newest information on each autonomic symptom in Parkinson's disease

The book is organized into sections/chapters. Section I, The Renin-Angiotensin-Aldosterone System (RAAS) in health and disease, conveys topics like an overview and history of RAAS discovery and its significance in cardiovascular physiology, the RAAS in the cardiovascular system, including the cardiorenal axis, and other RAAS endocrine systems (in the liver, lungs, adrenal glands, and testes). RAAS pathways and second messengers (Cyclic AMP, Calcium), and receptors [AT1R, AT2R, MasR binding to the vasodilator angiotensin-(1-7)], medications targeting the RAAS, and effects of the RAAS on inflammation. Oxidative stress, vascular smooth muscle contraction, endothelial dysfunction, fibrosis, and the hypertrophic, anti-apoptotic, and pro-mitogenic effects of Angiotensin II. RAAS local brain systems and pleiotropic effects, including neuroinflammation, autophagy, endoplasmic reticulum stress, and mitochondrial dysfunction. Section II, the Renin-Angiotensin System (RAS) in Parkinson’s disease, deals with general considerations, pathogeny and pharmacotherapeutics, the RAS and Alzheimer’s disease and other neurodegenerative diseases, neuroprotective and anti-inflammatory properties of AT2 in motor neuron disease treatment, Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA); RAS modulation of dopaminergic neurotransmission: effects on Parkinson’s disease motor symptoms, motor fluctuations, memory, cognition and mood; ACEIs and ARBs’ therapeutic benefits on mood and depressive symptoms; brain RAS as a potential therapeutic target in psychiatric disorders; the risk of Parkinson’s disease and the use of Renin-angiotensin modulators; brain RAS regulation of stress and neuroinflammation, and participation of the hypothalamic-pituitary-adrenal axis; risk of Parkinson’s disease and the use of RAS modulators; the relationship between RAS, COVID-19, and Parkinson’s disease; RAS, Parkinson, and COVID-19: ACE2 and post COVID-19 parkinsonism; the relationship between RAS and other pathological conditions that increase PD risk. RAS role in the pathophysiology of diabetes and complications - nephropathy and retinopathy; gut microbiota and local gastrointestinal RAS two-way interaction; gut dysbiosis and impaired renin-angiotensin system (RAS) function in cognitive decline and neurodegeneration; gut microbiota impact on RAS-related disorders; gastrointestinal dopaminergic and renin-angiotensin systems; gut ACE2, probiotics supplementation, and diabetic retinopathy in type 1 diabetes; Ang-(1-7) protection in diabetes and diabetic retinopathy; ACE2 gene therapy improvement of glycemic control in diabetic mice.The Renin-Angiotensin-Aldosterone System (RAS) in health and disease.RAS pathways and second messengers (Cyclic AMP, Calcium), and receptors [AT1R, AT2R, MasR binding to the vasodilator angiotensin-(1-7)], medications targeting the RAS.Brain RAS and other local RAS pathways. Neurodegenerative disorders. Gut microbiota and local gastrointestinal RAS two-way interaction; gut dysbiosis and impaired renin-angiotensin system (RAS) function in cognitive decline and neurodegeneration.

Myoclonous, Volume 11 in the International Review of Movement Disorders series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Classification & Scales & Treatment, Electrophysiology, Diagnostic approach including differential diagnosis, Clinical Myclonus Syndromes, Cortical myclonus tremor, Spectrum of Progressive myclonus ataxia - Progressive myclonus epilepsy, Myclonus-dystonia, Functional myclonus, Genetic myclonus including genetic Metabolic disorders causing myclonus, Acquired myclonus (Toxic- and drug-induced, hypoxic-ischemic, Metabolic (non-genetic) and Inflammatory myclonus), Autoimmune and paraneoplastic myclonus, Neurodegenerative disorders and myclonus, and much more.Provides the latest information on Myoclonous researchOffers outstanding and original reviews on a range of Myoclonous research topicsServes as an indispensable reference for researchers and students alike

International Review of Movement Disorders series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.Provides the latest information on Recent Advances in Movement DisordersOffers outstanding and original reviews on a range of Recent Advances in Movement Disorders research topicsServes as an indispensable reference for researchers and students alike

This book offers a comprehensive approach to the wide range of movement disorders, an important specialty in the field of neurology, guiding readers from the phenomenology to diagnosis and management. Reflecting the latest developments in the field, it offers a unique summary of this dynamic area by pursuing a uniform approach to movement disorders curricula. Divided into three parts, Movement Disorders Curricula provides an authoritative overview of this growing branch of neurology. The first part presents the basic elements of movement disorders, including descriptions of the anatomy and physiology of the basal ganglia. It also features sections on clinical trials for movement disorders, practical skills, and rating scales. The second and third part examine in detail hypokinetic and hyperkinetic movement disorders, respectively. Equipping readers with the practical and research skills needed in the movement disorders field, the book offers a valuable tool to help them prepare for board examinations on general neurology, as well as for fellowships in movement disorders.