Peter Jenner – författare

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.* * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This volume is a collection of chapters covering recent advances in the field of neurobiology. Chapters address anesthetic binding sites on the nicotinic acetylcholine receptors, NMDA receptor signal regulation, alcohol self-administration in rodents, and dopamine receptor mutations in mice.

A well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research This volume is a collection of chapters covering recent advances in the field of neurobiology Chapters address anesthetic binding sites on the nicotinic acetylcholine receptors, NMDA receptor signal regulation, alcohol self-administration in rodents, and dopamine receptor mutations in mice

This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.

Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson's disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction.

Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson's disease Each chapter covers a specific autonomic symptom: classification, assessment, treatment Presents the newest information on each autonomic symptom in Parkinson's disease

The book is organized into sections/chapters. Section I, The Renin-Angiotensin-Aldosterone System (RAAS) in health and disease, conveys topics like an overview and history of RAAS discovery and its significance in cardiovascular physiology, the RAAS in the cardiovascular system, including the cardiorenal axis, and other RAAS endocrine systems (in the liver, lungs, adrenal glands, and testes). RAAS pathways and second messengers (Cyclic AMP, Calcium), and receptors [AT1R, AT2R, MasR binding to the vasodilator angiotensin-(1-7)], medications targeting the RAAS, and effects of the RAAS on inflammation. Oxidative stress, vascular smooth muscle contraction, endothelial dysfunction, fibrosis, and the hypertrophic, anti-apoptotic, and pro-mitogenic effects of Angiotensin II. RAAS local brain systems and pleiotropic effects, including neuroinflammation, autophagy, endoplasmic reticulum stress, and mitochondrial dysfunction. Section II, the Renin-Angiotensin System (RAS) in Parkinson’s disease, deals with general considerations, pathogeny and pharmacotherapeutics, the RAS and Alzheimer’s disease and other neurodegenerative diseases, neuroprotective and anti-inflammatory properties of AT2 in motor neuron disease treatment, Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA); RAS modulation of dopaminergic neurotransmission: effects on Parkinson’s disease motor symptoms, motor fluctuations, memory, cognition and mood; ACEIs and ARBs’ therapeutic benefits on mood and depressive symptoms; brain RAS as a potential therapeutic target in psychiatric disorders; the risk of Parkinson’s disease and the use of Renin-angiotensin modulators; brain RAS regulation of stress and neuroinflammation, and participation of the hypothalamic-pituitary-adrenal axis; risk of Parkinson’s disease and the use of RAS modulators; the relationship between RAS, COVID-19, and Parkinson’s disease; RAS, Parkinson, and COVID-19: ACE2 and post COVID-19 parkinsonism; the relationship between RAS and other pathological conditions that increase PD risk. RAS role in the pathophysiology of diabetes and complications - nephropathy and retinopathy; gut microbiota and local gastrointestinal RAS two-way interaction; gut dysbiosis and impaired renin-angiotensin system (RAS) function in cognitive decline and neurodegeneration; gut microbiota impact on RAS-related disorders; gastrointestinal dopaminergic and renin-angiotensin systems; gut ACE2, probiotics supplementation, and diabetic retinopathy in type 1 diabetes; Ang-(1-7) protection in diabetes and diabetic retinopathy; ACE2 gene therapy improvement of glycemic control in diabetic mice.The Renin-Angiotensin-Aldosterone System (RAS) in health and disease.RAS pathways and second messengers (Cyclic AMP, Calcium), and receptors [AT1R, AT2R, MasR binding to the vasodilator angiotensin-(1-7)], medications targeting the RAS.Brain RAS and other local RAS pathways. Neurodegenerative disorders. Gut microbiota and local gastrointestinal RAS two-way interaction; gut dysbiosis and impaired renin-angiotensin system (RAS) function in cognitive decline and neurodegeneration.

Effects of Climate Change in Movement Disorders, Volume 10 in the International Review of Movement Disorders series, highlights new advances in the field, with this updated volume presenting interesting chapters on a variety of timely topics, including Climate Change and the Global Burden of Parkinson’s Disease and Movement Disorders, Air Pollution and Neurotoxicity: The Role of Environmental Pollutants in Movement Disorders, Extreme Heat, Sleep Disruption, and the Glymphatic System: Implications for Parkinson’s Disease, Climate-Driven Changes in Vector-Borne Diseases and Neuroinfections: Risks for Movement Disorders, The Impact of Climate Change on Food Security and Nutritional Deficiencies in Movement Disorders, and much more.Other sections cover Invisible Invaders: The Emerging Threat of Microplastics to Brain Health and Movement Disorders, Socioeconomic and Healthcare Disparities in Climate-Related Vulnerability for Parkinson's Disease and Movement Disorders, The Role of Heat Stress, Oxidative Damage, and Neuroinflammation in Parkinson’s disease Pathophysiology, Climate-Linked Disruptions in Medication Availability and Treatment Strategies in movement disorders, and more.Provides the latest information on Effects of Climate Change in Movement Disorders researchOffers outstanding and original reviews on a range of Effects of Climate Change in Movement Disorders research topicsServes as an indispensable reference for researchers and students alike

Myoclonous, Volume 11 in the International Review of Movement Disorders series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Classification & Scales & Treatment, Electrophysiology, Diagnostic approach including differential diagnosis, Clinical Myclonus Syndromes, Cortical myclonus tremor, Spectrum of Progressive myclonus ataxia - Progressive myclonus epilepsy, Myclonus-dystonia, Functional myclonus, Genetic myclonus including genetic Metabolic disorders causing myclonus, Acquired myclonus (Toxic- and drug-induced, hypoxic-ischemic, Metabolic (non-genetic) and Inflammatory myclonus), Autoimmune and paraneoplastic myclonus, Neurodegenerative disorders and myclonus, and much more.Provides the latest information on Myoclonous researchOffers outstanding and original reviews on a range of Myoclonous research topicsServes as an indispensable reference for researchers and students alike

International Review of Movement Disorders series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.Provides the latest information on Recent Advances in Movement DisordersOffers outstanding and original reviews on a range of Recent Advances in Movement Disorders research topicsServes as an indispensable reference for researchers and students alike