Daria Mochly-Rosen – författare

Improve your lifelong health and well-being by understanding what mitochondria really do for you, and how through small lifestyle changes, these awe-inspiring powerhouses can better your life.Have you ever wondered what makes every heartbeat, every thought, and every movement possible? Meet your mitochondria—tiny but mighty organelles that are the true engines of life. These organelles are popularly known as the “powerhouses of the cell,” but new research shows that the mitochondria do more than just convert food into energy—they’re orchestrators of critical functions that keep you healthy and alive. This groundbreaking book by a leading scientist from Stanford University School of Medicine and her husband, a bestselling author, is the first to provide a comprehensive yet easy-to-understand look at mitochondria and their vital role in human health. It is based on the premise that healthy mitochondria are the key to healthy cells and, thus, to healthy tissues, healthy organs, and a healthy body. The Life Machines provides practical and fundamental principles that you can use to unlock your body’s full potential, answering questions like:-How does exercise help mitochondria improve your muscles and your brain?-What nutrients do mitochondria thrive on, and how is your gut microbiome involved?-How can developing better sleeping habits improve your mitochondrial health?-Why relaxing and managing stress will reduce damage to your mitochondria?-How can you protect your mitochondria from toxins in the environment?-Why mitochondria are the key to healthy aging We are only as healthy as our mitochondria. Dysfunction of these organelles has been linked to diseases and conditions such as Alzheimer’s disease, type 2 diabetes, heart diseases, cancer, depression, autism spectrum disorder, chronic fatigue syndrome, and infertility. Now, the remarkable progress in understanding the mitochondrial role in these ailments will shape the future of medicine. Packed with surprising facts, you’ll read about “mitochondrial Eve” who lived in Africa 200,000 years ago; tiny rotors that spin inside your body at fantastic speed; how cancer cells steal mitochondria from immune cells; how mitochondria help shape a baby’s fingers and brain; how mitochondria in your thighs are linked to your cognitive capacity, and more. Skillfully weaving cutting-edge scientific discoveries, expert testimonies, personal stories, and practical insights, The Life Machines is inspiring and hopeful, empowering you to adopt lifestyle changes that will benefit the smallest—and yet most crucial—parts of the human body.

“This delightful, enthusiastic book will change your life.” —Daniel E. Lieberman, author of Exercised Improve your lifelong health and well-being by understanding what mitochondria really do for you, and how through small lifestyle changes, these awe-inspiring powerhouses can better your life.Have you ever wondered what makes every heartbeat, every thought, and every movement possible? Meet your mitochondria—tiny but mighty organelles that are the true engines of life. These organelles are popularly known as the “powerhouses of the cell,” but new research shows that the mitochondria do more than just convert food into energy—they’re orchestrators of critical functions that keep you healthy and alive. This groundbreaking book by a leading scientist from Stanford University School of Medicine and her bestselling author husband, is the first to provide a comprehensive yet easy-to-understand look at mitochondria and their vital role in human health. Dysfunction of the organelles has been linked to diseases and conditions such as Alzheimer’s disease, type 2 diabetes, heart diseases, cancer, depression, autism spectrum disorder, chronic fatigue syndrome, and infertility. The Life Machines provides practical and fundamental principles that you can use to unlock your body’s full potential, answering questions like: -How does exercise help mitochondria improve your muscles and your brain?-What nutrients do mitochondria thrive on, and how is your gut microbiome involved?-How can better sleeping habits improve your mitochondrial health?-Why relaxing and managing stress will reduce damage to your mitochondria? -Why protecting your mitochondria is key to healthy aging?Skillfully weaving cutting-edge scientific discoveries, expert testimonies, personal stories, and practical insights, The Life Machines is inspiring and hopeful, empowering you to adopt lifestyle changes that will benefit the smallest—and yet most crucial—parts of the human body.

Improve your lifelong health and well-being by understanding what mitochondria really do for you, and how through small lifestyle changes, these awe-inspiring powerhouses can better your life.Have you ever wondered what makes every heartbeat, every thought, and every movement possible? Meet your mitochondriatiny but mighty organelles that are the true engines of life. These organelles are popularly known as the '';powerhouses of the cell,'' but new research shows that the mitochondria do more than just convert food into energythey''re orchestrators of critical functions that keep you healthy and alive. This groundbreaking book by a leading scientist from Stanford University School of Medicine and her husband, a bestselling author, is the first to provide a comprehensive yet easy-to-understand look at mitochondria and their vital role in human health. It is based on the premise that healthy mitochondria are the key to healthy cells and, thus, to healthy tissues, healthy organs, and a healthy body. The Life Machines provides practical and fundamental principles that you can use to unlock your body''s full potential, answering questions like: -How does exercise help mitochondria improve your muscles and your brain? -What nutrients do mitochondria thrive on, and how is your gut microbiome involved? -How can developing better sleeping habits improve your mitochondrial health? -Why relaxing and managing stress will reduce damage to your mitochondria? -How can you protect your mitochondria from toxins in the environment? -Why mitochondria are the key to healthy aging We are only as healthy as our mitochondria. Dysfunction of these organelles has been linked to diseases and conditions such as Alzheimer''s disease, type 2 diabetes, heart diseases, cancer, depression, autism spectrum disorder, chronic fatigue syndrome, and infertility. Now, the remarkable progress in understanding the mitochondrial role in these ailments will shape the future of medicine. Packed with surprising facts, you''ll read about '';mitochondrial Eve'' who lived in Africa 200,000 years ago; tiny rotors that spin inside your body at fantastic speed; how cancer cells steal mitochondria from immune cells; how mitochondria help shape a baby''s fingers and brain; how mitochondria in your thighs are linked to your cognitive capacity, and more. Skillfully weaving cutting-edge scientific discoveries, expert testimonies, personal stories, and practical insights, The Life Machines is inspiring and hopeful, empowering you to adopt lifestyle changes that will benefit the smallestand yet most crucialparts of the human body.

"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review of first edition from Nature Chemical Biology

Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to start transforming their basic research discoveries into novel drugs. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. This comprehensive book lays out simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.

Each chapter broadly discusses an important topic in drug development, from discovery, optimization and preclinical studies through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest.

The SPARK model has been adopted in over 60 institutions on six continents, and the program has been honored with multiple awards including the 2020 Xconomy Award for Ecosystem Development, the 2020 Cures Within Reach Award for Patient Impact Research, and the 2022 California Life Sciences Pantheon Award for Academia, Non-Profits, & Research.

The new edition updates every chapter with the latest developments since the 2014 publication of the first edition.

"A lot of hard-won knowledge is laid out here in a brief but informative way. Every topic is well referenced, with citations from both the primary literature and relevant resources from the internet." Review of first edition from Nature Chemical BiologyWritten by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to start transforming their basic research discoveries into novel drugs. Often many potentially transformative basic science discoveries are not pursued because they are deemed ‘too early’ to attract industry interest. This comprehensive book lays out simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.Each chapter broadly discusses an important topic in drug development, from discovery, optimization and preclinical studies through clinical trial design, regulatory issues and marketing assessments. After the practical overview provided here, the reader is encouraged to consult more detailed texts on specific topics of interest.The SPARK model has been adopted in over 60 institutions on six continents, and the program has been honored with multiple awards including the 2020 Xconomy Award for Ecosystem Development, the 2020 Cures Within Reach Award for Patient Impact Research, and the 2022 California Life Sciences Pantheon Award for Academia, Non-Profits, & Research.The new edition updates every chapter with the latest developments since the 2014 publication of the first edition.