David Castle – författare

There is substantial contemporary interest in psychedelic agents as medicines for maladies of the mind. This follows research in the 1950s and 1960s exploring the use of LSD and other psychedelics to treat a range of psychiatric illnesses as well as addictions. This research was shut down after prohibition of these drugs, however the last decade has seen a major renewal of interest in the therapeutic use of psychedelics and related drugs in psychiatry. Psilocybin (found in 'magic mushrooms') has been used effectively for amelioration of distress in people with depression/anxiety in the context of potentially life-ending cancers, as well as for treatment-resistant depression and also addictions. MDMA ('ecstasy') has shown efficacy for severe post-traumatic stress disorder, with enduring benefit. Other psychedelics, both plant-derived (e.g., ayahuasca) and synthetically produced (e.g., LSD) are also being investigated for their potential therapeutic value. These agents not only herald a new neurobiology but also allow an integration of psychotherapy with biological compounds that is truly novel and that challenges established psychiatric practice. Furthermore, the action of these agents on the brain allows an exploration of how the brain works to 'open up' to psychotherapeutic healing. Published as part of the Oxford Psychiatry Library series, the book provides an overview of this hugely exciting field, covering the history of psychedelics, clinical aspects, risks and side effects, precautions and processes.

The new science of nutrigenomics and its ethical and societal challenges Gene-diet interactions--which underlie relatively benign lactose intolerance to life-threatening conditions such as cardiovascular disease--have long been known. But until now, scientists lacked the tools to fully understand the underlying mechanisms that cause these conditions. In recent years, however, strides in human genomics and the nutritional sciences have allowed for the advancement of a new science--dubbed nutrigenomics. Although this science may lead to personalized nutrition and dietary recommendations that can mitigate, prevent, or cure sickness, current oversight mechanisms and regulations for emerging direct-to-public nutrigenomic tests are still in their infancy. Science, Society, and the Supermarket: The Opportunities and Challenges of Nutrigenomics discusses the many ethical, legal, and social challenges presented by nutrigenomics. Concerning itself with the basic uses of nutrigenomic research as well as its clinical and commercial aspects, this text sheds light on such issues as:* Opportunities and challenges for nutrigenomics* The science of nutrigenomics* The ethics of nutrigenomic tests and information both in a clinical setting and by private third parties* Alternatives for nutrigenomics service delivery* Nutrigenomics and the regulation of health claims for foods and drugs* Equity and access to nutrigenomics in industrialized and developing countries* Intellectual property issues By taking a proactive bioethical stance on the subject, Science, Society, and the Supermarket offers a thorough and timely analysis on both the benefits and risks of nutrigenomics. Along with a thought-provoking examination of the issues, this book provides ethical guidelines and recommendations for further study in policy and regulatory development.

Mood and anxiety disorders in women represent an increasingly important area of research and treatment development. The authors take a broad biopsychosocial and developmental approach to the issues, beginning with anxiety disorders in adolescence and progressing through the life phases of women to menopause and old age. All the disorders are covered, from anxiety and borderline personality disorder to stress and late-life depression. Particular attention is paid to questions of vulnerability; epidemiological and clinical evidence showing gender differences in such disorders; aetiological explanations in terms of biological (including hormonal) as well as psychosocial parameters, and treatment implications.

The second edition of A Primer of Clinical Psychiatry provides a broad overview of the major topics in psychiatry and provides the clinical skills necessary for competent clinical practice. It also includes an up-to-date overview of the scientific literature behind this fascinating and challenging medical discipline.

This book covers in detail the psychiatric interview, the mental state examination, and clinical investigations relevant to psychiatry.

All of the major syndromes of psychiatry are addressed including schizophrenia, depressive disorders, bipolar disorder, anxiety, post-traumatic disorders, obsessive-compulsive disorders, eating disorders, somatoform disorders and personality disorders and cover epidemiology, aetiology and clinical aspects, and discussion of specific treatment approaches.

A separate section reviews biological and psychosocial aspects of treatment in psychiatry, with worked case examples. A chapter on psychiatric emergencies is included in this section.

Discrete chapters cover specialist areas such as child and adolescent psychiatry, old age psychiatry, forensic psychiatry, dual disability and substance use disorders.

Enhancing each chapter is a case-based role-play scenario, complete with model answers. Each scenario is set out to model modern pedagogical theory, with roles, setting, tasks, and model answers all articulated and cross-referenced to the core text. Readers can adopt various roles within the scenarios, including that of the doctor (general practice registrars, interns, and residents), allied health staff, or patients themselves and their relatives. The scenarios cover everything from basic skills such as taking a history or describing a disorder, to more advanced problems, such as working with the hostile family and assessing risk in the emergency setting. This case-based role-play approach is ideal for those preparing for psychiatry Observed Structured Clinical Examinations (OSCEs).

A Primer of Clinical Psychiatry 2nd edition aims to introduce the pertinent facts of clinical psychiatry to medical students and students of mental health disciplines. It will also be a useful resource for established clinicians, including GPs and the more advanced psychiatric trainee or mental health professional.

This book is a compendium of knowledge, experience and insight on agriculture, biotechnology and development. Beginning with an account of GM crop adoptions and attitudes towards them, the book assesses numerous crucial processes, concluding with detailed insights into GM products. Drawing on expert perspectives of leading authors from 57 different institutions in 16 countries, it provides a unique, global overview of agbiotech following 20 years of adoption. Many consider GM crops the most rapid agricultural innovation adopted in the history of agriculture. This book provides insights as to why the adoption has occurred globally at such a rapid rate.This is a rich and varied collection of research, which will appeal to scholars, academics and practitioners worldwide. An invaluable resource, this book will be a first point of reference to anyone with an interest in agbiotech and studies into agriculture, biotechnology and development.Contributors: A.A. Adenle, P. Aerni, C. Alexander, J.M. Alston, V. Beckmann, J. Bognar, C.G. Borroto, D. Brewin, G. Brookes, J. Carpenter, Y. Carrière, D. Castle, M. Chen, P. Conceição, B. Dayananda, M. Demont, K. Dillen, D. Eaton, E. Einsiedel, J. Falck-Zepeda, J. Fernandez-Cornejo, G.B. Frisvold, C.V. Gonslaves, D. Gonsalves, M. Gouse, G. Graff, R. Gray, A. Gupta, W.O. Hennessey, J.E. Hobbs, W.E. Huffman, L. A. Jackson, C. Juma, N. Kalaitzandonakes, S. Kaplan, V.J. Karplus, W.A. Kerr, G.G. Khachatourians, E.M. Kikulwe, E. Kim, D.E. Kolady, S.P. Kowalski, J. Kruse, L. Levidow, S. Levine, K. Ludlow, X. Ma, A. Magnier, S. Malla, I. Matuschke, J.J. McCluskey, A. McHughen, J. Medlock, D. Miller, L. Nagarajan, A. Naseem, C. Oguamanam, M. Ouattarra, M. Owen, R. Paarlberg, P. W. B. Phillips, M. Qaim, T. Raney, J.M. Reeves, S.D. Rhodes, S.M.H. Rizvi, C.D. Ryan, D. Schimmelpfennig, G.J. Scoles, G. Skogstad, S. J. Smyth, C. Soregaroli, D.J. Spielman, A.J. Stein, J. Thomson, J. Vitale, G. Vognan, G. Waterfield, S. Wechsler, J. Wesseler, A. Williams, W.W. Wilson, L.L. Wolfenbarger, G. Ye, J. Yorobe Jr, D.Z. Zeng, D. Zilberman

An updated third edition of this award-winning book provides a comprehensive overview of the complex associations between cannabis and mental illness. Organised into easy to navigate sections, the book has been fully revised to feature eight entirely new chapters covering important novel aspects. Marijuana and Madness incorporates new research findings on the potential use of cannabinoids, and synthetic cannabinoids, in an array of mental illnesses, balanced against the potential adverse effects. The associations between cannabis and psychosis, developing putative models of 'cannabis induced' psychosis and pathways to schizophrenia are all covered. The book importantly discusses the impact of exposure to cannabis at various stages of neurodevelopment (in utero, in childhood, and during adolescence) and it thoroughly reviews the treatments for cannabis dependence and health policy implications of the availability of increasingly high potency cannabis. This book will quickly become an essential resource for all members of the mental health team.

Olfaction and its relation to mental health is an area of growing interest, evidenced by the 2004 Nobel Prize in Physiology or Medicine being awarded for discoveries relating to odorant receptors and the organization of the olfactory system. Olfaction is of particular interest to specialists seeking a fuller understanding of schizophrenia. Clear deficits in the sense of smell could predict schizophrenia in apparently unaffected individuals. In this book, first published in 2006, Warrick Brewer and his team of experts set out our understanding of olfaction and mental health, relating it to broader principles of neural development and processing as a foundation for understanding psychopathology. The neuropathological, neuropsychological and neuropsychiatric aspects of olfactory function and dysfunction are all covered (drawing on neuroimaging techniques where appropriate), and indications for future research and applications are discussed.

Although research shows that there is a silent crisis in men's mental health, there remains surprisingly little literature on the subject. This important textbook provides up-to-date, practical and evidence-based information on how mental health issues affect men and the way treatments should be offered to them. Key opinion leaders from across the globe have been brought together to offer much-needed understanding about the socio-politico-economic context of men's lives today as well as ethnic and cultural effects and genetic, epigenetic and gene-environment interaction. Clinically focused chapters cover topics such as suicide and self-harm, violence, sociopathy and substance misuse in men; depression, anxiety and related disorders; and psychotic and cognitive disorders. The book uses a lifespan approach to assessment and treatment, accounting for age and developmental phase. An invaluable source of information for clinical specialists and trainees in psychiatry, psychology, and mental health nursing as well as social workers, and occupational therapists.

Keith Culver and David Castle Introduction Aquaculture is at the leading edge of a surprisingly polarized debate about the way we produce our food. According to the United Nations Food and Agriculture Organization, aquaculture production has increased 8. 8% per year since 1970, far surpassing productivity gains in terrestrial meat production at 2. 8% in the same period (FAO 2007). Like the ‘green revolution’ before it, the ‘blue revolution’ in aquaculture promises rapidly increased productivity through technology-driven - tensi?cation of aquaculture animal and plant production (Costa-Pierce 2002; The Economist 2003). Proponents of further aquaculture development emphasize aq- culture’s ancient origins and potential to contribute to global food security d- ing an unprecedented collapse in global ?sheries (World Fish Center; Meyers and Worm 2003; Worm et al. 2006). For them, technology-driven intensi?cation is an - dinary and unremarkable extension of past practice. Opponents counter with images of marine and freshwater environments devastated by intensive aquaculture pr- tices producing unsustainable and unhealthy food products. They view the promised revolutionasascam,nothingmorethanclever marketingbypro?t-hungry ?shfa- ers looking for ways to distract the public from the real harms done by aquaculture. The stark contrast between proponents and opponents of modern aquaculture recalls decades of disputes about intensive terrestrial plant and animal agriculture, disputes whose vigor shows that the debate is about much more than food production (Ruse and Castle 2002).

Canada’s thirteen provinces and territories are significant actors in Canadian society, directly shaping cultural, political, and economic domains. Regions also play a key role in creating diversity within innovative activity. The role of provinces and territories in setting science, technology, and innovation policy is, however, notably underexplored. Ideas, Institutions, and Interests examines each province and territory to offer real-world insights into the complexity and opportunities of regionally differentiated innovation policy in a pan-continental system. Contributing scholars detail the distinctive ways in which provinces and territories articulate ideas and interests through their institutions, programs, and policies. Many of the contributing authors have engaged first-hand with either micro- or macro-level policy innovation and are innovation leaders in their own right, providing invaluable perspectives on the topic. Exploring the vital role of provinces in the last thirty years of science, technology, and innovation policy development and implementation, Ideas, Institutions, and Interests is an insightful book that places innovation policy in the context of multilevel governance.

Finally, the real story about corporate America with its increased reliance on consultants. Since the 1990s, consulting solutions have become the de facto standard for solving business problems and providing cover for corporate decision makers. This is not the typical CEO whitewash, or business management primer. Steve Romaine offers a view never before shared with management or stockholders as he takes a hired gun's journey beginning at the outside looking in, and ending at the pinnacle of a corporation's power.Based on his experience of working for IBM, his later role as a self-employed consultant, and finally his responsibilities as senior vice president for NationsBank, Romaine makes it clear that the issues leading to the collapse of Enron were not isolated events. Soldier of Fortune 500 explores corporate cronyism between executives and their consultants, and builds a convincing case of how, without the proper safeguards, such cozy relationships can lead to pervasive problems, placing stockholders, employees, and the future viability of the American corporation at risk.This book is a must read for corporate managers, employees, and anyone involved with the consulting business.

Recent innovations in agriculture and food technologies have brought benefits to many countries, particularly in developing regions, but information about the extent of these has often been sparse. This research review examines the best papers on the subject to form a comprehensive, global perspective on the impacts of agricultural biotechnology around the world. With an emphasis on the economic, environmental, health and food security aspects of agbiotech, Biotechnology, Agriculture and Development will prove to be an invaluable resource for academics, students and researchers alike.

This book is a compendium of knowledge, experience and insight on agriculture, biotechnology and development. Beginning with an account of GM crop adoptions and attitudes towards them, the book assesses numerous crucial processes, concluding with detailed insights into GM products. Drawing on expert perspectives of leading authors from 57 different institutions in 16 countries, it provides a unique, global overview of agbiotech following 20 years of adoption. Many consider GM crops the most rapid agricultural innovation adopted in the history of agriculture. This book provides insights as to why the adoption has occurred globally at such a rapid rate.This is a rich and varied collection of research, which will appeal to scholars, academics and practitioners worldwide. An invaluable resource, this book will be a first point of reference to anyone with an interest in agbiotech and studies into agriculture, biotechnology and development.Contributors: A.A. Adenle, P. Aerni, C. Alexander, J.M. Alston, V. Beckmann, J. Bognar, C.G. Borroto, D. Brewin, G. Brookes, J. Carpenter, Y. Carrière, D. Castle, M. Chen, P. Conceição, B. Dayananda, M. Demont, K. Dillen, D. Eaton, E. Einsiedel, J. Falck-Zepeda, J. Fernandez-Cornejo, G.B. Frisvold, C.V. Gonslaves, D. Gonsalves, M. Gouse, G. Graff, R. Gray, A. Gupta, W.O. Hennessey, J.E. Hobbs, W.E. Huffman, L. A. Jackson, C. Juma, N. Kalaitzandonakes, S. Kaplan, V.J. Karplus, W.A. Kerr, G.G. Khachatourians, E.M. Kikulwe, E. Kim, D.E. Kolady, S.P. Kowalski, J. Kruse, L. Levidow, S. Levine, K. Ludlow, X. Ma, A. Magnier, S. Malla, I. Matuschke, J.J. McCluskey, A. McHughen, J. Medlock, D. Miller, L. Nagarajan, A. Naseem, C. Oguamanam, M. Ouattarra, M. Owen, R. Paarlberg, P. W. B. Phillips, M. Qaim, T. Raney, J.M. Reeves, S.D. Rhodes, S.M.H. Rizvi, C.D. Ryan, D. Schimmelpfennig, G.J. Scoles, G. Skogstad, S. J. Smyth, C. Soregaroli, D.J. Spielman, A.J. Stein, J. Thomson, J. Vitale, G. Vognan, G. Waterfield, S. Wechsler, J. Wesseler, A. Williams, W.W. Wilson, L.L. Wolfenbarger, G. Ye, J. Yorobe Jr, D.Z. Zeng, D. Zilberman

Pharmacological and Psychosocial Treatments in Schizophrenia provides a succinct clinical overview of key areas pertinent to the holistic treatment of people with schizophrenia and, in particular, puts firmly back onto the agenda the importance of psychosocial treatments.The latest data concerning the newer antipsychotic agents and clinical guidelines for their use are reviewed. The real emphasis, however, is on the psychosocial interventions for specific aspects of schizophrenia symptomatology and disability that have been shown to offer major benefits to recovery in the disorder, and yet have failed to have a high profile in the literature, as more effective biological treatments have become available.This book offers practical guidance on effective strategies for use in both clinical settings and in the family context, placing the patient (and their family) once again at the centre of therapeutic endeavours. Encouraging professionals to offer a broader therapeutic approach, this book will offer real hope to therapists, patients and families of what can be achieved if psychosocial interventions complement the many psychopharmacological treatments available today.Key topics include: female patients, treatment resistance, the substance abuser patient, family intervention, helping the patient at work, managing violent behaviour, first episode psychosis and rating scales in schizophrenia.

Intellectual property rights (IPRs), particularly patents, occupy a prominent position in innovation systems, but to what extent they support or hinder innovation is widely disputed. Through the lens of biotechnology, this book delves deeply into the main issues at the crossroads of innovation and IPRs to evaluate claims of the positive and negative impacts of IPRs on innovation. An international group of scholars from a range of disciplines - economic geography, health law, business, philosophy, history, public health, management - examine how IPRs actually operate in innovation systems, not just from the perspective of theory but grounded in their global, regional, national, current and historical contexts. In so doing, the contributors seek to uncover and move beyond deeply held assumptions about the role of IPRs in innovation systems.Scholars and students interested in innovation, science and technology policy, intellectual property rights and technology transfer will find this volume of great interest. The findings will also be of value to decision makers in science and technology policy and managers of intellectual property in biotechnology and venture capital firms.

Keith Culver and David Castle Introduction Aquaculture is at the leading edge of a surprisingly polarized debate about the way we produce our food. According to the United Nations Food and Agriculture Organization, aquaculture production has increased 8. 8% per year since 1970, far surpassing productivity gains in terrestrial meat production at 2. 8% in the same period (FAO 2007). Like the ‘green revolution’ before it, the ‘blue revolution’ in aquaculture promises rapidly increased productivity through technology-driven - tensi?cation of aquaculture animal and plant production (Costa-Pierce 2002; The Economist 2003). Proponents of further aquaculture development emphasize aq- culture’s ancient origins and potential to contribute to global food security d- ing an unprecedented collapse in global ?sheries (World Fish Center; Meyers and Worm 2003; Worm et al. 2006). For them, technology-driven intensi?cation is an - dinary and unremarkable extension of past practice. Opponents counter with images of marine and freshwater environments devastated by intensive aquaculture pr- tices producing unsustainable and unhealthy food products. They view the promised revolutionasascam,nothingmorethanclever marketingbypro?t-hungry ?shfa- ers looking for ways to distract the public from the real harms done by aquaculture. The stark contrast between proponents and opponents of modern aquaculture recalls decades of disputes about intensive terrestrial plant and animal agriculture, disputes whose vigor shows that the debate is about much more than food production (Ruse and Castle 2002).