David S. Latchman – författare

Gene therapy offers considerable potential for the treatment of various incurable diseases of the nervous system. Viral Vectors for Treating Disease of the Nervous System describes a number of different viral vectors developed for achieving high efficiency gene delivery to the brain. Vectors described include those based on adenovirus, adeno-associated virus, Herpes Simplex Virus, lentivirus, and other retroviruses. It also discusses the potential application of such viruses in treating brain tumors, Parkinson's disease, and other diseases of the nervous system. Provides up-to-date account of gene therapy approaches for incurable neurological disorders Describes a range of gene delivery methods based on different viruses

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events. Potential of transcription factors as therapeutic targets in human disease Importance of histone modifications Use of genome-based sequence analysis and high-throughput methods Applications of the chromatin immunoprecipitation (ChIP) assay Transcriptional elongation Regulation by post-translational modifications Regulatory networks and bioinformatics

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.

This third, fully revised, edition brings the reader right up to date with the recent advances made in the study of disease at the molecular and cellular level, and examines the exciting new possibilities for treatment. Its clear and straightforward style will give doctors, medical students, and researchers valuable insight into molecular medicine and its applications.

The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams.The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.

The new edition of Gene Control, for the first time, provides extensive coverage on prokaryotic gene regulation, which makes it the only textbook offering a complete and detailed account of gene control for both prokaryotic and eukaryotic organisms. The core objective of this edition is to educate students about the fundamental principles and mechanisms governing gene expression, regulation, and function. To reinforce these ideas, each chapter now includes discussion questions to promote critical thinking. There are also multiple choice questions and animations for students, and a large question bank and figure slides for instructors. The textbook also emphasizes the vital role of scientific experiments and evidence in shaping our current understanding of gene control and provides comprehensive coverage of essential gene expression techniques and methodologies throughout the book.This extensively updated edition of the renowned textbook Gene Control will remain a valuable resource for students, instructors, researchers, and medical professionals exploring various aspects of gene control, ranging from the regulation of genes in infectious diseases to embryonic development across different organisms, from bacteria to humans.

The new edition of Gene Control, for the first time, provides extensive coverage on prokaryotic gene regulation, which makes it the only textbook offering a complete and detailed account of gene control for both prokaryotic and eukaryotic organisms. The core objective of this edition is to educate students about the fundamental principles and mechanisms governing gene expression, regulation, and function. To reinforce these ideas, each chapter now includes discussion questions to promote critical thinking. There are also multiple choice questions and animations for students, and a large question bank and figure slides for instructors. The textbook also emphasizes the vital role of scientific experiments and evidence in shaping our current understanding of gene control and provides comprehensive coverage of essential gene expression techniques and methodologies throughout the book.This extensively updated edition of the renowned textbook Gene Control will remain a valuable resource for students, instructors, researchers, and medical professionals exploring various aspects of gene control, ranging from the regulation of genes in infectious diseases to embryonic development across different organisms, from bacteria to humans.

The stress proteins or heat shock proteins were originally identified on the basis of their enhanced synthesis following stress. It is now clear, however, that they also play a key role in stressed cells and in specific human diseases. This book provides a comprehensive account of these proteins, emphasizing the functions of the different stress proteins in unstressed and stressed cells of different types, their regulation by stressful and non-stressful stimuli and their roles in a range of human diseases.