Dev Bukhsh Singh – författare

Genome Analysis: Principles and Methods provides recent and advanced information about genome analysis approaches and techniques to study and annotate the structure and function of the genome. It is a compendium of important topics such as NGS analysis, genome fragmentation and assembly, metagenomics, cloning and expression, physical marker analysis, transcriptome data analysis, sequence alignment and comparison, evolutionary analysis, SNP analysis, genome-based disease diagnosis and therapies, micro-RNAs, pharmacogenomics, genetic approaches to disease intervention, and challenges with opportunities in genome analysis and genomics, etc.The latest developments in the field are discussed, and key concepts are introduced to ensure readers understand advanced concepts and methodologies in the area. The book serves as a valuable guide to the present, emerging, and evolving research methodologies in the field.

Medicinal Biotechnology: Methods and Applications covers a wide range of topics from traditional herbal medicine to recent plant and animal biotechnology approaches used for the production of vaccines, hormones, enzymes, edible medicinal products, herbal therapeutics, and other secondary metabolites. The book opens with a historical perspective of medicinal biotechnology which includes a discussion of successive development in the field of medicine, starting from early civilization up to current and advanced approaches and strategies.The book also provides a wide range of topics that include: a discussion engineering approaches in medicinal biotechnology, metabolomics, extraction of metabolites, personalization approaches, and strategies for the effective use of medicinal product and drugs; explanation of engineering approaches in medicinal biotechnology, metabolomics, extraction of metabolites, personalization approaches, and strategies for the effective use of medicinal product and drug; and coverage of specific knowledge on the production and use in vaccines, antibodies, and hormones.

This book explores the pharmacological potentials of various classes of plant secondary metabolites. The initial chapter introduces the chemical diversity, biosynthesis pathways, and ecological functions of plant secondary metabolites. It discusses the pivotal role of transcription factors in regulating their production. Further, the book examines the specific classes of secondary metabolites, such as phenolic compounds, terpenes, and anthocyanins, highlighting their properties and various applications across food, cosmetics, and pharmaceutical industries. The book delves into emerging areas such as plant metabolites as nutraceuticals, the utilization of horticultural and vegetable crops for secondary metabolite production, and the exploration of staple crops for health improvements. The chapters discuss the applications of fungal endosymbionts and algal sources in shaping plant metabolite compositions. The chapters further review the innovative techniques such as hairy root engineering and recombinant systems for enhancing metabolite production. The book concludes with a detailed overview of methods for isolating and identifying secondary metabolites. This book is essential resource for students, researchers, and professionals of ethnopharmacology, pharmaceutical sciences, botany, and biomedical sciences.

Key Features:

1) Covers various classes of plant secondary metabolites and their pharmacological potentials.

2) Explores the role of transcription factors in controlling secondary metabolite production in plants. 3) Discusses secondary metabolites from horticultural and vegetable crops, highlighting their pharmaceutical applications.

4) Presents techniques like hairy root engineering and recombinant systems for enhancing metabolite production.

5) Examine lichen metabolites and their applications in human health, as well as metabolites from gymnosperms.

This book explores the pharmacological potentials of various classes of plant secondary metabolites. The initial chapter introduces the chemical diversity, biosynthesis pathways, and ecological functions of plant secondary metabolites. It discusses the pivotal role of transcription factors in regulating their production. Further, the book examines the specific classes of secondary metabolites, such as phenolic compounds, terpenes, and anthocyanins, highlighting their properties and various applications across food, cosmetics, and pharmaceutical industries. The book delves into emerging areas such as plant metabolites as nutraceuticals, the utilization of horticultural and vegetable crops for secondary metabolite production, and the exploration of staple crops for health improvements. The chapters discuss the applications of fungal endosymbionts and algal sources in shaping plant metabolite compositions. The chapters further review the innovative techniques such as hairy root engineering and recombinant systems for enhancing metabolite production. The book concludes with a detailed overview of methods for isolating and identifying secondary metabolites. This book is essential resource for students, researchers, and professionals of ethnopharmacology, pharmaceutical sciences, botany, and biomedical sciences.

Key Features:

1) Covers various classes of plant secondary metabolites and their pharmacological potentials.

2) Explores the role of transcription factors in controlling secondary metabolite production in plants. 3) Discusses secondary metabolites from horticultural and vegetable crops, highlighting their pharmaceutical applications.

4) Presents techniques like hairy root engineering and recombinant systems for enhancing metabolite production.

5) Examine lichen metabolites and their applications in human health, as well as metabolites from gymnosperms.

This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances.

This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling.

Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

 This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic biomarkers. Further, it discusses challenges associated with the clinical implications of therapeutic proteins, including safety, immunogenicity, protein stability, degradation, and efficacy. It illustrates the development of biosimilar antibodies, optimization strategies for producing biobetter antibodies, and presents fundamental concepts about biosuperior therapeutics. Lastly, it includes a discussion about protein-based vaccines against bacterial and viral infections.