Devalina Ray - Böcker

The exceptional capability of N-heterocyclic scaffolds to function as biomimetics and active pharmacophores has resulted in modulating their structure, reactivity and formulation for effective drugs. The direct and viable synthetic strategies of these molecules are valuable features. Numerous methods revealed the general synthesis and application of N-heterocyclic compounds through conventional as well as modified approaches. Additionally, the advent of combinatorial and medicinal chemistry for the synthesis of new heterocyclic compounds for drug discovery have added a new essence to existing protocol.Key FeaturesBridges the gap by integrating both chemical and biological aspects of heterocycles in a cohesive and comprehensive manner.Serves as a valuable resource for researchers, students, and professionals who need focused insights into heterocyclic chemistry and its applications in biology.Offers new perspectives on how these compounds influence or can be influenced by biological systems, and how they may be utilized in fields of drug design and development.Illustrates the importance of the ring size of heterocyclic compounds and heteroatoms involved with its biological applications.The biological evaluation and significance of various chiral and achiral heterocycles along with chemical strategies will attract the scientific community.

Heterocyclic systems are defined by the integration of one or more heteroatoms within a cyclic framework and serve as the structural foundation for a vast array of natural products, clinical pharmaceuticals, and advanced functional materials. This work examines the synthetic landscape of heterocycles, prioritizing the development of robust methodologies, mechanistic insights, and late-stage modifications. Given their pervasive role in modulating anticancer, antimicrobial, and anti-inflammatory and many other pathways, these scaffolds remain central to medicinal chemistry. By elucidating the intricate interplay between chemical architecture and pharmacological efficacy, this study promotes the thought process to the rational design of next-generation therapeutic agents.Key FeaturesBridges the gap by integrating both chemical and biological aspects of heterocycles in a cohesive and comprehensive manner.Serves as a valuable resource for researchers, students, and professionals who need focused insights into heterocyclic chemistry and its applications in biology.Offers new perspectives on how these compounds influence or can be influenced by biological systems, and how they may be utilized in fields of drug design and development.Illustrates the importance of the ring size of heterocyclic compounds and heteroatoms involved with its biological applications.The biological evaluation and significance of various chiral and achiral heterocycles along with chemical strategies will attract the scientific community.