Ellen Fanning – författare

DNA replication is a key event in the cell cycle. Althoughour knowledge is far from complete and many elusiveregulatory mechanisms still remain beyondour grasp, manyenzymes and a multiplicity of biochemical mechanismsinvolved have been discovered. Recent findings in E. colihave confirmed and yet surpassed the original hypothesis ofF. Jacob. In yeast and higher eucaryotes, the apparentredundancy in putative origins and initiators has made anestimation of the importance of each identified elementdifficult to access. In spite of well establishedmethodologies - which are also described in the book - theorigin identification in mammalian chromosomes is still acontroversial subject. On the other hand, considerableadvances have been made in our understanding of virus DNAreplication and this continues to deepen and broaden ourunderstanding of the controls of cellular DNA replication.

DNA replication is a key event in the cell cycle. Althoughour knowledge is far from complete and many elusiveregulatory mechanisms still remain beyondour grasp, manyenzymes and a multiplicity of biochemical mechanismsinvolved have been discovered. Recent findings in E. colihave confirmed and yet surpassed the original hypothesis ofF. Jacob. In yeast and higher eucaryotes, the apparentredundancy in putative origins and initiators has made anestimation of the importance of each identified elementdifficult to access. In spite of well establishedmethodologies - which are also described in the book - theorigin identification in mammalian chromosomes is still acontroversial subject. On the other hand, considerableadvances have been made in our understanding of virus DNAreplication and this continues to deepen and broaden ourunderstanding of the controls of cellular DNA replication.

Provided here is an easily accessible introduction to themechanisms of DNA replication, regulation and thebiochemistry of cell cycle control. An overview of thisrapidly developing field is presented to orient the reader,followed by a series of contributions by leading researcherssummarizing recent results on selected topics, such asprotein phosporylation, tumor suppressor genes, and signaltransduction in prokaryotic and eucaryotic systems. Thereader will gain an overview of our current understanding ofDNA replication and the cell cycle, and a selection ofuseful recent references for further reading.