Ellen Kuhl – författare

Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader''s understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models.

Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines.

Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

This innovative textbook brings together modern concepts in mathematical epidemiology, computational modeling, physics-based simulation, data science, and machine learning to understand one of the most significant problems of our current time, the outbreak dynamics and outbreak control of COVID-19. It teaches the relevant tools to model and simulate nonlinear dynamic systems in view of a global pandemic that is acutely relevant to human health.

If you are a student, educator, basic scientist, or medical researcher in the natural or social sciences, or someone passionate about big data and human health: This book is for you! It serves as a textbook for undergraduates and graduate students, and a monograph for researchers and scientists. It can be used in the mathematical life sciences suitable for courses in applied mathematics, biomedical engineering, biostatistics, computer science, data science, epidemiology, health sciences, machine learning, mathematical biology, numerical methods, and probabilistic programming. This book is a personal reflection on the role of data-driven modeling during the COVID-19 pandemic, motivated by the curiosity to understand it.

This book contains a collection of papers that were presented at the IUTAM Symposium

on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011.

It contains state-of-the-art papers on:

- Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates

- Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling

- Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure

- Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media

- Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics