F. Krück – författare

F. Kruck It is a great pleasure for me to welcome you to the workshop on Natriuretic Hormone here in Bonn. For quite a long time we have been considering the possibility of assem­ bling scientists who are concerned with and interested in the problem of a possible humoral natriuretic activity. Work has been done on this topic in different parts of the world, partially with different methods and sometimes also with different and contlict­ ing results. And thus we thought it could be very beneficial to have personal discussions with all of you so as to reach a consensus of opinion on how studies should be contin­ ued. In spite of the current fmancial shortCOmings, common to most of the countries you are living in, we felt it necessary to use all the money we were granted for our research work in clinicopharmacologic studies to organize this meeting. And so we did. Thanks to the help of different pharmaceutical companies we were able to defer the travel ex­ penses and costs for hotel accomodation for the speakers. Thus this meeting is not going to be a luxurious one, but rather a meeting for working and especially for discussions. And now by way of opening this workshop, lowe you a few explanations.

Recent experimental and clinical research performed by outstanding authorities has enabled us to characterize fundamental processes that govern the regulation of salt and water content of the body. Their results have provided not only an important gain of insight into mechanisms at the cellular level but also the possibility to integrate single cell activities into a complex organ function. Moreover, this knowledge enables scientists to develop broader concepts concerning the regulation of organ function and thus contributes to a better understanding of the overall status in health and disease. In the present volume some of these physiologists and clinicians discuss principal questions of humoral and non-humoral influences involved in the control of electro­ lyte and fluid content of the organism. It contains three essential topics: Data concerning basic principles of cell behaviour and transport processes are followed by the description of natriuretic substances and their influence on volume regulation. Finally, attempts are undertaken to elucidate the meaning of these basic principles for the explanation of the development of patholocigal states. This symposion was held in honor to Professor H. P. Wolff, one of the internatio­ nally wellknown pioneers in this field of clinical research. The editors· wish to express their graditude to the Melusin-Schwarz-Monheim GmbH for the generous support of the symposion.

F. Kruck It is a great pleasure for me to welcome you to the workshop on Natriuretic Hormone here in Bonn. For quite a long time we have been considering the possibility of assem­ bling scientists who are concerned with and interested in the problem of a possible humoral natriuretic activity. Work has been done on this topic in different parts of the world, partially with different methods and sometimes also with different and contlict­ ing results. And thus we thought it could be very beneficial to have personal discussions with all of you so as to reach a consensus of opinion on how studies should be contin­ ued. In spite of the current fmancial shortCOmings, common to most of the countries you are living in, we felt it necessary to use all the money we were granted for our research work in clinicopharmacologic studies to organize this meeting. And so we did. Thanks to the help of different pharmaceutical companies we were able to defer the travel ex­ penses and costs for hotel accomodation for the speakers. Thus this meeting is not going to be a luxurious one, but rather a meeting for working and especially for discussions. And now by way of opening this workshop, lowe you a few explanations.

Im Juni 1979 hatte in Dusseldorf ein Symposion uber Diuretika stattgefunden. Behandelt wurden experimentelle und klinische Ergebnisse mit Diuretika, unter anderem mit Diucomb. Ziel des Symposions war, Untersuchungsergebnisse zu referieren und diskutieren. Teilnehmer waren Wissenschaft- ler aus der Schweiz, Osterreich, Grossbritannien, USA und der Bundesrepublik Deutschland. Das Material dieses Symposions wurde uberarbeitet, Diskussionen durch einen Redaktionsstab gestrafft. Wir danken Frau J. BOROS fur wertvolle technische Assistenz. Der Springer-Verlag hat uns wiederum sach- kundig beraten und ist in grosszugiger Weise unseren Wunschen entgegengekommen Die Herausgeber Inhaltsverzeichnis Einleitung. F. KRUCK ...1 1. Wirkungsmechanismen. Moderation: K. GREEFF . 3 Plasma Concentrations and Comparative Bioavailability of Bemetizide and Triamterene in Combination. L. F. CHASSEAUD ...5 Pharmakokinetik von Diuretika bei eingeschrankter Nierenfunktion. H. KNAUF und E. MUTSCHLER 14 Diskussion 24 Neue Daten zur Toxizitat von Diuretika. F. LEUSCHNER 26 Diskussion 29 2. Renale Wirkungen. Moderation: O. KRAuPP...33 Die Wirkungsweise diuretischer Substanzen in Abhangigkeit von ihrer re- len Behandlung. P. DEETJEN ...35 Effects of Diuretics on Renal Potassium and Hydrogen Ion Transport. G. GIEBISCH and M. HROPOT ...42 Wirkungen von Diuretika auf den transzellularen Elektrolyttransport der Niere. M. WIEDERHOLT und L. L. HANsEN 53 Diskussion 60 Interaktion zwischen Diuretika und renalem Prostaglandinsystem. H. J. KRAMER, B. STINNESBECK, W. PRIOR und R. DUSING 64 71 Diskussion Untersuchungen zum Wirkungsmechanismus von Acetazolamid und SITS auf den Bikarbonattransport im proximalen Tubulus der Rattenniere.

Recent experimental and clinical research performed by outstanding authorities has enabled us to characterize fundamental processes that govern the regulation of salt and water content of the body. Their results have provided not only an important gain of insight into mechanisms at the cellular level but also the possibility to integrate single cell activities into a complex organ function. Moreover, this knowledge enables scientists to develop broader concepts concerning the regulation of organ function and thus contributes to a better understanding of the overall status in health and disease. In the present volume some of these physiologists and clinicians discuss principal questions of humoral and non-humoral influences involved in the control of electro­ lyte and fluid content of the organism. It contains three essential topics: Data concerning basic principles of cell behaviour and transport processes are followed by the description of natriuretic substances and their influence on volume regulation. Finally, attempts are undertaken to elucidate the meaning of these basic principles for the explanation of the development of patholocigal states. This symposion was held in honor to Professor H. P. Wolff, one of the internatio­ nally wellknown pioneers in this field of clinical research. The editors· wish to express their graditude to the Melusin-Schwarz-Monheim GmbH for the generous support of the symposion.