Gail A. Van Norman - Böcker

In this issue of Anesthesiology Clinics, guest editors Drs. Neal H. Cohen and Gail van Norman bring their considerable expertise to the topic of Ethical Approaches to the Practice of Anesthesiology - Part 1: Overview of Ethics in Clinical Care: History and Evolution. In this first of a two-part series, top experts discuss topics such as the role of advance directives and living wills on anesthesia practice; preoperative care of the patient with DNR orders; end-of-life care: withdrawing/withholding support; brain death: medical, ethical, cultural, legal aspects; ethics consult in anesthesia practice; and more.

Moving Toward Nonanimal Approaches in Medical Research and Testing pioneers a single-source guide for researchers regarding nonanimal research tools and methodologies and their many advantages and applications in place of animals. This book is presented in three parts: historical, ethical, legislative, and scientific contexts on the need to shift away from animal-based research and testing; the latest advances in nonanimal tools and methods for biomedical research and testing of human therapeutics and other compounds, including microphysiological systems, bioprinting, biobanks, and artificial intelligence; and achieving a practical shift toward these powerful approaches, including advocacy for legal, regulatory, and policy change, securing funding for nonanimal studies, and how to overcome bias against nonanimal methods. This book, primarily directed to researchers in biomedicine, human medical therapeutics, and toxicology, will also appeal to researchers in industry, providing overview and insights about the latest applications of nonanimal research tools and methods for product development and testing. Clinicians who wish to understand the reliability of testing therapeutics with nonanimal versus animal methods, as well as advocacy groups seeking an up-to-date understanding of ethical, economic, political, and scientific considerations in moving toward nonanimal approaches, will also find significant value in this text. Finally, legislators and those involved in regulatory review and oversight will benefit from this single comprehensive source for developing a basic understanding of nonanimal research and human safety.Presents an overview of historical, ethical, and scientific issues regarding animal and nonanimal research and testing approachesDelivers the latest in nonanimal experimental advances and applicationsProvides practical guidance about overcoming funding, publication, and other hurdles for researchers using nonanimal approachesDiscusses legislative, policy, and advocacy approaches to advancing nonanimal approaches

In this issue of Anesthesiology Clinics, guest editors Drs. Neal H. Cohen and Gail van Norman bring their considerable expertise to the topic of Ethical Approaches to the Practice of Anesthesiology - Part 2: Ethical Constructs that Impact Health Policy, Research, and Professional Integrity. In this second of a two-part series, top experts discuss topics such as health equity and social determinants of health; diversity and inclusion in anesthesia practice; ethical principles of clinical and translational research; ethics and controversies in animal subjects research and impact on clinical decision-making; falsification and fabrication in research data; and more.