Gerald Pöch – författare

Scientists struggling with the pharmaco-and toxicodynamic interactions of drugs and chemicals will find this a valuable reference to the relevant theoretical background of a complex field as well as a guide to practical, analytical procedures for the evaluation of experimental data. A mechanistically-based analysis of observed combination effects is backed up by numerous examples as well as computer-assisted plotting and curve fitting, using popular graphical software systems. Readers can proceed directly to the evaluation of their own dose-response experiments with respect to independent actions and additive interactions, where appropriate. The meanings of terms and acronyms are illucidated by a comprehensive glossary.

The setting of limit values for environmental noxae is essentially based on measurements and data from single exposures. To an increasing degree, however, there are demands also to consider combined exposures. Hence, in this study, the necessity and feasability of environmental standards for combined exposures have been examined from the scientific, medical, economic, legal, sociological and philosophical/ethical perspective. Starting from effect mechanisms, criteria have been established which, in spite of the complexity of the issues, enable us to set limit values in order to achieve given environmental quality targets. This study endeavours to reveal and explain gaps in knowledge and to point to possible solutions from the scientific and medical point of view. The results should support efforts to shape a practical legal framework and viable economic procedures for environmental standards on combined exposures, taking into consideration the standards and perceptions existing in our communities.