Geraldo A. Passos - Böcker
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6 produkter
6 produkter
2 089 kr
Skickas inom 5-8 vardagar
This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.
2 111 kr
Skickas inom 10-15 vardagar
The study of transcriptomics is key to understanding complex diseases. The new edition will address how transcriptomics may be used in combination with genetic strategies to identify causative genes in monogenic and complex genetic diseases.
Del 1429 - Advances in Experimental Medicine and Biology
Genome Editing in Biomedical Sciences
Inbunden, Engelska, 2023
2 391 kr
Skickas inom 7-10 vardagar
This volume focuses on applying the Crispr system in editing the genome of human cells (in vitro and in vivo) and model organisms used in biomedical research. With the advent of Crispr technology, genome editing soon became a procedure of great interest to laboratories worldwide due to its relative ease and accuracy. In biomedical sciences, genome editing by Crispr has already enabled the development of new experimental model systems. In medicine, therapeutic alternatives for the genetic "correction" of diseases have already begun to appear. Therefore, the book's purpose is to bring in a single volume, chapters that show the scientific community in biomedicine, medicine, human genetics, oncology, virology, and parasitology, among others, the advances in genomic editing. In a chapter dedicated to the ethical aspects of human genomic editing, we also address what we can and should do with this (bio)technology. The book chapters were written by productive researchers specializing in Crispr genome editing. The chapters cover the concept of Crispr and genome editing and how to use this new methodology in biomedical research and medicine, among other aspects, including the ethical controversy around its use in humans. The writing of the chapters keeps a specialized language intelligible enough for those who want to introduce themselves to the subject.
634 kr
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Del 1471 - Advances in Experimental Medicine and Biology
Thymus Transcriptome and Cell Biology
Inbunden, Engelska, 2025
2 499 kr
Skickas inom 10-15 vardagar
This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene.
1 425 kr
Skickas inom 10-15 vardagar
Transcriptomics in Heath and Disease provides a comprehensive overview of the science of transcriptomics initially in health, focusing on the concept of the transcriptome and the main methods to evaluate it.