Harvey J. Clewell III – författare
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3 produkter
3 produkter
Inbunden, Engelska, 2005
2 080 kr
Skickas inom 5-8 vardagar
A definitive, single source of information on PBPK modelingPhysiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind.This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for:* Halogenated Alkanes* Halogenated Alkenes* Alkene and Aromatic Compounds* Reactive Vapors in the Nasal Cavity* Alkanes, Oxyhydrocarbons, and Related Compounds* Pesticides and Persistent Organic Pollutants* Dioxin and Related Compounds* Metals and Inorganic Compounds* Drugs* Antineoplastic Agents* Perinatal Transfer* Mixtures* Dermal Exposure ModelsIn addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.
E-bok
PDF, Engelska, 20052 381 kr
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A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becoming increasingly important in human health risk assessments and in supporting pharmacodynamic modeling for toxic responses. Organized by classes of compounds and modeling purposes so users can quickly access information, this is the first comprehensive reference of its kind. This book presents an overview of the underlying principles of PBPK model development. Then it provides a compendium of PBPK modeling information, including historical development, specific modeling challenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers can explore diverse modeling techniques and applications. An authoritative reference for toxicologists, ecotoxicologists, risk assessors, regulators, pharmacologists, pharmacists, and graduate students in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles information from leaders in the field and discusses future directions for PBPK modeling.
Inbunden, Engelska, 2027
536 kr
Kommande
Chemical products are ubiquitous in the modern world. They offer many economic and societal benefits but can also present threats to human health and can cause pollution related to their manufacture and use. This revised third edition has been significantly updated to include the latest scientific tools and regulations. It begins by describing the principles and practices of epidemiology and toxicology, then proceeds to explain how this research is applied in practice to establish regulations needed to protect health and to develop risk assessment framework. It features an entirely new chapter on emerging risk assessment science, an expanded discussion of exposure science, and the most recent developments in law and regulation., Written in accessible language, Calculated Risks will be of interest to advanced undergraduate and graduate students taking courses in risk assessment, toxicology or environmental chemistry, and to researchers, professionals and decision makers involved in chemical safety and regulation.