Herbert B. Newton – författare

Treatment of patients with a brain tumor remains one of the most challenging and difficult areas of modern oncology. Recent advances in the molecular biology of these neoplasms have improved our understanding of the malignant phenotype and have lead to the development of novel forms of chemotherapy, including "targeted agents. The Handbook of Brain Tumor Chemotherapy reviews the state-of-the-art of chemotherapy development and clinical treatment of patients with this devastating disease.Handbook of Brain Tumor Chemotherapy offers a unique cutting-edge compendium of basic science and clinical information on the subject of brain tumor chemotherapy, reviewing what has been accomplished thus far and how the field will continue to evolve with the development of more specific and efficacious chemotherapeutic agents. This book represents the most complete single-volume resource available for information on the subject of brain tumor chemotherapy.- Provides the most up to date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics, for the treatment of brain tumors- Broadly appeals to anyone interested in the field of Neuro-Oncology and in the treatment of patients with brain tumors- Useful to clinicians interested in a thorough overview of the use of chemotherapy in patients with a broad range of brain tumors as well as serving as a source of background information to basic scientists and pharmaceutical researchers with an interest in the molecular therapeutics of brain tumors

Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive, "single-source books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.

Patients with brain tumor-related epilepsy (BTRE) suffer from two serious pathologies simultaneously - a brain tumor and a secondary form of epilepsy.� Although there has been remarkable progress in BTRE research in recent years, it remains an on-going challenge for clinicians and continues to stimulate much debate in the scientific community.� This volume is the first to be completely dedicated to BTRE, and in doing so it explores issues faced by the health care team as well as some of the novel and promising directions that future research may take. Epilepsy and Brain Tumors is not only a complete reference on BTRE but also a practical guide based on clinical experiences, with a comprehensive collection of presentations from international experts who share some of the latest discoveries and their approaches to tackling a wide range of difficult and complex issues.

Includes coverage of epidemiology, pathology and treatment of both primary and metastatic brain tumors Offers additional insight into supportive care, incidence in children, focal epileptogenesis, clinical evaluation, antiepileptic drugs, surgical treatment, cognitive rehabilitation, and more Chapters authored and edited by leaders in the field around the globe - the broadest, most expert coverage available

Patients with brain tumor-related epilepsy (BTRE) suffer from two serious pathologies simultaneously – a brain tumor and a secondary form of epilepsy. Although there has been remarkable progress in BTRE research in recent years, it remains an on-going challenge for clinicians and continues to stimulate much debate in the scientific community. This volume is the first to be completely dedicated to BTRE, and in doing so it explores issues faced by the health care team as well as some of the novel and promising directions that future research may take. Epilepsy and Brain Tumors is not only a complete reference on BTRE but also a practical guide based on clinical experiences, with a comprehensive collection of presentations from international experts who share some of the latest discoveries and their approaches to tackling a wide range of difficult and complex issues.- Includes coverage of epidemiology, pathology and treatment of both primary and metastatic brain tumors- Offers additional insight into supportive care, incidence in children, focal epileptogenesis, clinical evaluation, antiepileptic drugs, surgical treatment, cognitive rehabilitation, and more- Chapters authored and edited by leaders in the field around the globe – the broadest, most expert coverage available

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment.

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Provides a background to translational research and the use of brain imaging for brain tumors Contains critical discussions on the potential and limitations of neuroimaging as a translational tool for the diagnosis and treatment of brain tumor and neuro-oncology patients Presents an up-to-date reference on advanced imaging technologies, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), as well as the recent refinements in these techniques

Remarkable progress in neuro-oncology due to increased utilization of advanced imaging in clinical practice continues to accelerate in recent years. Refinements in magnetic resonance imaging (MRI) and computed tomography (CT) technology, and the addition of newer anatomical, functional, and metabolic imaging methods, such as MRS, fMRI, diffusion MRI, and DTI MRI have allowed brain tumor patients to be diagnosed much earlier and to be followed more carefully during treatment.With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this second edition of the Handbook of Neuro-Oncology Neuroimaging is so relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuro-Imaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the first edition, and in addition will feature several new important chapters covering diverse topics such as advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. It will also serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.- Provides a background to translational research and the use of brain imaging for brain tumors- Contains critical discussions on the potential and limitations of neuroimaging as a translational tool for the diagnosis and treatment of brain tumor and neuro-oncology patients- Presents an up-to-date reference on advanced imaging technologies, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), as well as the recent refinements in these techniques

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches.As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed.- Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors- Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors- Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods- Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Oligodendroglioma: Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment features the latest "cutting-edge" molecular biology, molecular therapeutics, imaging, immunotherapy, and research methods on the topic of oligodendrogliomas. The most detailed and comprehensive resource on the subject, it provides up-to-date information on clinical presentation, pathology, molecular biology, and treatment methods, including immunotherapy. This book is a critical for students, physicians and researchers in the fields of neuroscience, neuro-oncology, neurosurgery, radiation oncology, medical oncology, and others working in research or with patients.

Provides the most up-to-date information regarding the clinical presentation, pathology, molecular biology, and methods for the treatment of oligodendroglioma brain tumors, including surgical therapy, radiotherapy, molecular therapeutics, chemotherapy, and immunotherapy Broadly appeals to anyone interested in the field of neuro-oncology and the treatment of patients with oligodendrogliomas Useful to clinicians interested in a thorough overview of the basic science and treatment of oligodendrogliomas Includes a section on immunotherapy, with updates on the use of vaccines and immune-based treatment approaches applied to oligodendrogliomas

Oligodendroglioma: Clinical Presentation, Pathology, Molecular Biology, Imaging, and Treatment features the latest "cutting-edge" molecular biology, molecular therapeutics, imaging, immunotherapy, and research methods on the topic of oligodendrogliomas. The most detailed and comprehensive resource on the subject, it provides up-to-date information on clinical presentation, pathology, molecular biology, and treatment methods, including immunotherapy. This book is a critical for students, physicians and researchers in the fields of neuroscience, neuro-oncology, neurosurgery, radiation oncology, medical oncology, and others working in research or with patients.- Provides the most up-to-date information regarding the clinical presentation, pathology, molecular biology, and methods for the treatment of oligodendroglioma brain tumors, including surgical therapy, radiotherapy, molecular therapeutics, chemotherapy, and immunotherapy- Broadly appeals to anyone interested in the field of neuro-oncology and the treatment of patients with oligodendrogliomas- Useful to clinicians interested in a thorough overview of the basic science and treatment of oligodendrogliomas- Includes a section on immunotherapy, with updates on the use of vaccines and immune-based treatment approaches applied to oligodendrogliomas

Neurological Complications of Systematic Cancer and Antineoplastic Therapy, Second Edition provides an expanded, updated and in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses neurological complications related to treatments such as radiation and chemotherapy and is an essential reference for the practicing neurologist and oncologist.

Sections in this new release cover the pathophysiology and molecular biology of cancer and the metastatic phenotype, Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses, Metabolic and nutritional disorders, CNS infections, Neurological complications of immunotherapy and bone marrow transplants, Neurological complications of new molecular agents and immuno-modulatory drugs, and more.

Summarizes the neurologic effects of both cancer and cancer treatment Provides scientific and clinical information relevant to research and treatment Identifies neurological complications by tumor type and tumor therapy Covers GI, lung, breast, gynecological, head and neck cancers, and more Includes radiotherapy, chemotherapy, immunotherapy, and new drugs Contains melanoma, lymphoma, sarcoma, myeloma, leukemia, and more

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.

Summarizes translational research on brain imaging for brain tumors Discusses limitations of neuroimaging for diagnosis and treatment Presents advanced imaging technologies, including CT, MRI, and PET Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more

With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology.- Summarizes translational research on brain imaging for brain tumors- Discusses limitations of neuroimaging for diagnosis and treatment- Presents advanced imaging technologies, including CT, MRI, and PET- Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more

Neuropsychological and Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues. Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as are current practices for rehabilitation and targets for essential future interventions in vulnerable populations.This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology.

Discusses the neurocognitive implications of brain and systemic cancer treatmentsExamines the foundations of neuropsychological testing and daily life implications, including caregiver supportCovers the psychosocial implications of brain cancer, psychotherapeutic interventions, and cognitive rehabilitation

Neuropsychological & Psychosocial Foundations of Neuro-Oncology provides an in-depth review of common cognitive, psychological, and social manifestations that occur in patients with brain cancer and other neuro-oncological issues, Chapters discuss primary CNS tumors, brain metastases, leptomeningeal disease, paraneoplastic disorders, and many other topics. Effects of CNS and systemic cancer treatment (i.e., radiotherapy, chemotherapy, immunotherapy) are also examined, as wel as current practices for rehabilitation and targets for essential future interventions in vulnerable populations. This book is fully illustrated with pathology photomicrographs, CT and MRI images, tables, and molecular pathway diagrams. Bringing neuropsychological and behavioral health trial knowledge from the bench to the bedside, this volume is an essential reference for practicing neuro-oncologists, neuropsychologists, nurses, and others working in the field of neuro-oncology.- Discusses the neurocognitive implications of brain and systemic cancer treatments- Examines the foundations of neuropsychological testing and daily life implications, including caregiver support- Covers the psychosocial implications of brain cancer, psychotherapeutic interventions, and cognitive rehabilitation

The Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Third Edition offers a unique cutting-edge collection of basic science and clinical information on brain tumor chemotherapy research. This book represents the most complete, single-volume resource available for information on the subject of brain tumor chemotherapy. Including a multidisciplinary approach, this volume combines recent advances in tumor therapy with molecular biology, molecular therapeutics, immunobiology, and immunotherapy approaches in one compilation. Chapters new to this volume include cutting-edge research on the molecular underpinnings of brain tumors such as glioblastoma and other gliomas, and the targeted molecular therapies to consider for treatment.. Offers an up-to-date review of brain tumor chemotherapy. Includes separate chapters on all major brain tumor types. Includes an overview of molecular biology and developmental molecular therapeutics. Features new materials on molecular approaches to brain metastases, methylation analysis, liquid biopsy, cancer neuroscience, and RNA sequencing

The Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Third Edition offers a unique cutting-edge collection of basic science and clinical information on brain tumor chemotherapy research. This book represents the most complete, single-volume resource available for information on the subject of brain tumor chemotherapy. Including a multidisciplinary approach, this volume combines recent advances in tumor therapy with molecular biology, molecular therapeutics, immunobiology, and immunotherapy approaches in one compilation. Chapters new to this volume include cutting-edge research on the molecular underpinnings of brain tumors such as glioblastoma and other gliomas, and the targeted molecular therapies to consider for treatment.* Offers an up-to-date review of brain tumor chemotherapy* Includes separate chapters on all major brain tumor types* Includes an overview of molecular biology and developmental molecular therapeutics* Features new materials on molecular approaches to brain metastases, methylation analysis, liquid biopsy, cancer neuroscience, and RNA sequencing

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy.Highlights include: The pathophysiology and molecular biology of cancer and the metastatic phenotype Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses Metabolic and nutritional disorders CNS infections Neurological complications of immunotherapy and bone marrow transplantsAdditional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy. Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.

Neurological Complications of Systematic Cancer and Antineoplastic Therapy provides an in-depth review of common manifestations related to neurology that occur in patients with systemic cancer. These include brain metastases, spinal cord compression, cerebrovascular events, and leptomeningeal disease. The book also discusses less common complications such as paraneoplastic disorders and neoplastic plexopathy.Highlights include: The pathophysiology and molecular biology of cancer and the metastatic phenotype Metastatic spread to cranial and peripheral nerves and brachial and lumbosacral plexuses Metabolic and nutritional disorders CNS infections Neurological complications of immunotherapy and bone marrow transplants Additional chapters review problems related to each specific tumor type, such as breast, lung, and colorectal, as well as gynecological cancer, genitourinary cancer, and malignant melanoma. The book also discusses neurological complications related to treatments such as radiation and chemotherapy. Bringing clinical trial knowledge from the bench to the bedside, this volume is an essential reference for the practicing oncologist and neurologist.