Hong-Wen Deng - Böcker

This bookelucidates how genetic, biological and medical information can be applied tothe development of personalized healthcare, medication and therapies. Focusingon aspects of the development of evidence-based approaches in bioinformaticsand computational medicine, including data integration, methodologies, toolsand models for clinical and translational medicine, it offers an essentialintroduction to clinical bioinformatics for clinical researchers andphysicians, medical students and teachers, and scientists working with human disease-based omics and bioinformatics. Dr. XiangdongWang is a distinguished Professor of Medicine. He is Director of ShanghaiInstitute of Clinical Bioinformatics, Director of Fudan University Center forClinical Bioinformatics, Deputy Director of Shanghai Respiratory ResearchInstitute, Director of Biomedical Research Center, Fudan University ZhongshanHospital, Shanghai, China; Dr. Christian Baumgartner is a Professor of HealthCare and Biomedical Engineering at Institute of Health Care Engineering withEuropean Notified Body of Medical Devices, Graz University of Technology, Graz,Austria; Dr. Denis Shields is a Professor of ClinicalBioinformatics at Conway Institute, Belfield, Dublin, Ireland; Dr. Hong-Wen Dengis a Professor at Department of Biostatistics and Bioinformatics, Tulane UniversitySchool of Public Health and Tropical Medicine, USA; Dr. Jacques SBeckmann is a Professor and Director of Section of Clinical Bioinformatics,Swiss Institute of Bioinformatics, Switzerland.

This bookelucidates how genetic, biological and medical information can be applied tothe development of personalized healthcare, medication and therapies. Focusingon aspects of the development of evidence-based approaches in bioinformaticsand computational medicine, including data integration, methodologies, toolsand models for clinical and translational medicine, it offers an essentialintroduction to clinical bioinformatics for clinical researchers andphysicians, medical students and teachers, and scientists working with human disease-based omics and bioinformatics. Dr. XiangdongWang is a distinguished Professor of Medicine. He is Director of ShanghaiInstitute of Clinical Bioinformatics, Director of Fudan University Center forClinical Bioinformatics, Deputy Director of Shanghai Respiratory ResearchInstitute, Director of Biomedical Research Center, Fudan University ZhongshanHospital, Shanghai, China; Dr. Christian Baumgartner is a Professor of HealthCare and Biomedical Engineering at Institute of Health Care Engineering withEuropean Notified Body of Medical Devices, Graz University of Technology, Graz,Austria; Dr. Denis Shields is a Professor of ClinicalBioinformatics at Conway Institute, Belfield, Dublin, Ireland; Dr. Hong-Wen Dengis a Professor at Department of Biostatistics and Bioinformatics, Tulane UniversitySchool of Public Health and Tropical Medicine, USA; Dr. Jacques SBeckmann is a Professor and Director of Section of Clinical Bioinformatics,Swiss Institute of Bioinformatics, Switzerland.

This book reviews important topics in osteoporosis, with the emphasis on both clinical management and basic research of the disease. From the clinical perspective, topics covering pathogenesis, diagnosis, and treatment of osteoporosis are extensively elaborated. Several more chapters complement clinical overview of osteoporosis, that discuss the effects of nutrition and exercise to bone health, the application of biochemical markers in osteoporosis diagnosis, novel potential drug targets for osteoporosis treatment, and osteoporosis in males and in children. As the prevalence of osteoporosis now reaches epidemiological levels, epidemiology and social impacts of osteoporosis is also reviewed in the book. Basic research on osteoporosis is also highlighted in the book, with a number of chapters dedicated to the review of genetics of osteoporosis, animal models for osteoporosis, and statistical methods in osteoporosis study.

This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research.