Xiangdong Wang – författare

This bookelucidates how genetic, biological and medical information can be applied tothe development of personalized healthcare, medication and therapies. Focusingon aspects of the development of evidence-based approaches in bioinformaticsand computational medicine, including data integration, methodologies, toolsand models for clinical and translational medicine, it offers an essentialintroduction to clinical bioinformatics for clinical researchers andphysicians, medical students and teachers, and scientists working with human disease-based omics and bioinformatics. Dr. XiangdongWang is a distinguished Professor of Medicine. He is Director of ShanghaiInstitute of Clinical Bioinformatics, Director of Fudan University Center forClinical Bioinformatics, Deputy Director of Shanghai Respiratory ResearchInstitute, Director of Biomedical Research Center, Fudan University ZhongshanHospital, Shanghai, China; Dr. Christian Baumgartner is a Professor of HealthCare and Biomedical Engineering at Institute of Health Care Engineering withEuropean Notified Body of Medical Devices, Graz University of Technology, Graz,Austria; Dr. Denis Shields is a Professor of ClinicalBioinformatics at Conway Institute, Belfield, Dublin, Ireland; Dr. Hong-Wen Dengis a Professor at Department of Biostatistics and Bioinformatics, Tulane UniversitySchool of Public Health and Tropical Medicine, USA; Dr. Jacques SBeckmann is a Professor and Director of Section of Clinical Bioinformatics,Swiss Institute of Bioinformatics, Switzerland.

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author’s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects.

Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.

This book elucidates the genetic, biological, morphological and functional aspects of telocytes. Telocytes are a recently defined type of interstitial (stromal) cells, with very long (tens to hundreds of micrometres) and very thin prolongations (mostly below the resolving power of light microscopy). The book describes the presence of telocytes in various organs and tissues, details their morphological characteristics, explores their genomic and proteomic profiles, puts forward preclinical evidence of their application, and discusses their potential in the context of clinical therapeutics. As such, it offers a valuable guide for biologists and clinicians alike.

Dr. Xiangdong Wang is a distinguished Professor of Medicine. He is Director of the Shanghai Institute of Clinical Bioinformatics, Executive Director of the Clinical Science Institute at Fudan University Zhongshan Hospital, Shanghai, China; Dr. Dragos Cretoiu is an Associate Professor of Pathology at the Department of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest.

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinicalstudents and researchers in the field of mtDNA–associated diseases.

This volume in the series, Translational Bioinformatics, provides an up-to-date overview of genomic approaches to asthma. By applying unbiased “-omics” combined with disease-focused and hypothesis-driven approaches, it enhances readers’ understanding of the asthma endotype.

Furthermore, it elucidates how progress in -omics research, such as “genomic,” “transcriptomic,” “protomic,” and “metabolomic,” is applied in asthma, and reports on the related series of important breakthroughs in asthma development, classification, prevention and drug sensitivity. Also covering systems biology knowledge and methodologies, computational models and biostatistical methods to analyze big data, this book provides a valuable resource for scientists and researchers in the field of asthma and respiratory diseases.

This volume covers the emerging area of science, Clinical Lipidomics, which is the application of lipidology to the understanding of physiological and pathophysiological changes of lipidomes, with a special focus on lipidomic profiles in human diseases.

Lipidomics is widely used to map lipid molecular species in a biological system. Clinical lipidomic analysis has demonstrated the comprehensive characterization of molecular lipids in various severities, durations, and therapies as a critical tool in identification and validation of disease-specific biomarkers.

This volume on Clinical Lipidomics will add to the literature and help advance the knowledge of the pathogenesis, diagnosis, prevention and treatment of diseases. 

With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.

The Book mainly focuses on various aspects of regionalized management of medicine, related with updates of new biotechnology, application of therapeutic strategy, and understanding of disease-associated molecular mechanisms. The book also discusses how medical informatics, systems analysis, database sharing, and artificial intelligent can be applied for improving the quality of hospital managements, disease therapies, regional collaborations, and medical services.

This book serves as a professional reference book to clinicians and experts who are interested in medical informatics and artificial intelligence for diseases therapies and therapeutic strategy, better systems analysis and database sharing, and more efficient regional collaborations and medical services.