James Stevens - Böcker

Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent years, phar- ceutical companies have come under increasing pressure to introduce new blockbuster drugs into the marketplace more rapidly. Companies have responded to these pressures by introducing new technologies and new strategies to expedite drug discovery and development. Drug discovery and development have traditionally been divided into three separate processes (i. e. , discovery research, preclinical development, and clinical development) that ideally should be integrated both organizationally and functionally. Instead, separate and distinct discovery research, preclinical development, and clinical development divisions were created within many companies during the 1980s and 1990s, Because of their isolation, scientists in the discovery research divisions often were advancing drug candidates into preclinical development that had marginal drug-like properties. For the purpose of this presentation, “drug-like” properties refer to the molecule’s physicochemical, absorption-distribution-metabolism-excretion (ADME), and toxicological properties. Lacking optimal drug-like properties often caused these drug candidates to fail in preclinical or clinical development.

Digital Vernacular addresses the why and how of digital fabrication in hundreds of step-by-step color images, illuminating a set of working principles and techniques that join theory with practice. Authors James Stevens and Ralph Nelson reconcile local traditions and innovations with globally accessible methods and digital toolsets. By combining ethics with hardware, the book will root you in the origins of making, ensuring a lasting and relevant reference for your studio practice. The book opens with the origins and principles of the digital vernacular, then outlines digital vernacular tools including computer numerically controlled (CNC) mills, laser cutters, and 3D printers. You'll even learn to create your own digital fabrication tools out of inexpensive materials. The book concludes with the processes of the digital vernacular, including techniques for removing, joining, forming, and adding. A companion website at make-Lab.org hosts additional step-by-step processes and project outcomes.

Digital Vernacular addresses the why and how of digital fabrication in hundreds of step-by-step color images, illuminating a set of working principles and techniques that join theory with practice. Authors James Stevens and Ralph Nelson reconcile local traditions and innovations with globally accessible methods and digital toolsets. By combining ethics with hardware, the book will root you in the origins of making, ensuring a lasting and relevant reference for your studio practice. The book opens with the origins and principles of the digital vernacular, then outlines digital vernacular tools including computer numerically controlled (CNC) mills, laser cutters, and 3D printers. You'll even learn to create your own digital fabrication tools out of inexpensive materials. The book concludes with the processes of the digital vernacular, including techniques for removing, joining, forming, and adding. A companion website at make-Lab.org hosts additional step-by-step processes and project outcomes.

Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent years, phar- ceutical companies have come under increasing pressure to introduce new blockbuster drugs into the marketplace more rapidly. Companies have responded to these pressures by introducing new technologies and new strategies to expedite drug discovery and development. Drug discovery and development have traditionally been divided into three separate processes (i. e. , discovery research, preclinical development, and clinical development) that ideally should be integrated both organizationally and functionally. Instead, separate and distinct discovery research, preclinical development, and clinical development divisions were created within many companies during the 1980s and 1990s, Because of their isolation, scientists in the discovery research divisions often were advancing drug candidates into preclinical development that had marginal drug-like properties. For the purpose of this presentation, “drug-like” properties refer to the molecule’s physicochemical, absorption-distribution-metabolism-excretion (ADME), and toxicological properties. Lacking optimal drug-like properties often caused these drug candidates to fail in preclinical or clinical development.

Paul Bunyan (1925) is a novel by James Stevens. Written from a lifetime of experience as a logger and historian of the logging industry, Paul Bunyan is a masterful take on one of the defining legends of the Pacific Northwest. Combining his own stories with those he heard at logging camps as a young boy, Stevens earned a reputation as a leading folklorist of his time whose novels and songs continue to resonate decades after his death. “He could whip his weight in wildcats, could pull clouds out of the sky, or chew up stones, or tell the whole world anything!” Larger than life, Paul Bunyan is a logger whose legend began with the Papineau Rebellion of 1837. As a defender of young Queen Victoria’s right to the forests of Canada, Bunyan fought fiercely against French loggers alongside his comrades armed with mattocks, axes, and hooks. Emerging victorious, he settles down to a life in nature, building his logging camp and roaming the woods with his trusted blue ox Babe. From his boyhood in the lumber camps of Idaho to his time as a logger in Oregon, James Stevens collected the tales of Bunyan from the more experienced men of the woods, eventually becoming the foremost expert on one of the Pacific Northwest’s greatest heroes. With a beautifully designed cover and professionally typeset manuscript, this edition of James Stevens’ Paul Bunyan is a classic work of American literature reimagined for modern readers.