Jie Chen – författare

Visar alla böcker från författaren Jie Chen. Handla med fri frakt och snabb leverans.

59 produkter

Kategorier

59 produkter

Middle Class Without Democracy
Economic Growth and the Prospects for Democratization in China
AvJie Chen
E-bok
Engelska, 2013
388 kr
Läs direkt efter köp
What kind of role can the middle class play in potential democratization in such an undemocratic, late developing country as China? To answer this profound political as well as theoretical question, Jie Chen explores attitudinal and behavioral orientation of China''s new middle class to democracy and democratization. Chen''s work is based on a unique set of data collected from a probability-sample survey and in-depth interviews of residents in three major Chinese cities, Beijing, Chengdu and Xi''an--each of which represents a distinct level of economic development in urban China-in 2007 and 2008. The empirical findings derived from this data set confirm that (1) compared to other social classes, particularly lower classes, the new Chinese middle class-especially those employed in the state apparatus-tends to be more supportive of the current Party-state but less supportive of democratic values and institutions; (2) the new middle class''s attitudes toward democracy may be accounted for by this class''s close ideational and institutional ties with the state, and its perceived socioeconomic wellbeing, among other factors; (3) the lack of support for democracy among the middle class tends to cause this social class to act in favor of the current state but in opposition to democratic changes. The most important political implication is that while China''s middle class is not likely to serve as the harbinger of democracy now, its current attitudes toward democracy may change in the future. Such a crucial shift in the middle class''s orientation toward democracy can take place, especially when its dependence on the Party-state decreases and perception of its own social and economic statuses turns pessimistic. The key theoretical implication from the findings suggests that the attitudinal and behavioral orientations of the middle class-as a whole and as a part-toward democratic change in late developing countries are contingent upon its relationship with the incumbent state and its perceived social/economic wellbeing, and the middle class''s support for democracy in these countries is far from inevitable.
A Middle Class Without Democracy
Economic Growth and the Prospects for Democratization in China
AvJie Chen
Häftad, Engelska, 2014
660 kr
Skickas inom 5-8 vardagar
What kind of role can the middle class play in potential democratization in such an undemocratic, late developing country as China? To answer this profound political as well as theoretical question, Jie Chen explores attitudinal and behavioral orientation of China's new middle class to democracy and democratization. Chen's work is based on a unique set of data collected from a probability-sample survey and in-depth interviews of residents in three major Chinese cities, Beijing, Chengdu and Xi'an--each of which represents a distinct level of economic development in urban China-in 2007 and 2008. The empirical findings derived from this data set confirm that (1) compared to other social classes, particularly lower classes, the new Chinese middle class-especially those employed in the state apparatus-tends to be more supportive of the current Party-state but less supportive of democratic values and institutions; (2) the new middle class's attitudes toward democracy may be accounted for by this class's close ideational and institutional ties with the state, and its perceived socioeconomic wellbeing, among other factors; (3) the lack of support for democracy among the middle class tends to cause this social class to act in favor of the current state but in opposition to democratic changes. The most important political implication is that while China's middle class is not likely to serve as the harbinger of democracy now, its current attitudes toward democracy may change in the future. Such a crucial shift in the middle class's orientation toward democracy can take place, especially when its dependence on the Party-state decreases and perception of its own social and economic statuses turns pessimistic. The key theoretical implication from the findings suggests that the attitudinal and behavioral orientations of the middle class-as a whole and as a part-toward democratic change in late developing countries are contingent upon its with the incumbent state and its perceived social/economic wellbeing, and the middle class's support for democracy in these countries is far from inevitable.
A Middle Class Without Democracy
Economic Growth and the Prospects for Democratization in China
AvJie Chen
Inbunden, Engelska, 2013
1 386 kr
Skickas inom 5-8 vardagar
What kind of role can the middle class play in potential democratization in such an undemocratic, late developing country as China? To answer this profound political as well as theoretical question, Jie Chen explores attitudinal and behavioral orientation of China's new middle class to democracy and democratization. Chen's work is based on a unique set of data collected from a probability-sample survey and in-depth interviews of residents in three major Chinese cities, Beijing, Chengdu and Xi'an--each of which represents a distinct level of economic development in urban China-in 2007 and 2008. The empirical findings derived from this data set confirm that (1) compared to other social classes, particularly lower classes, the new Chinese middle class-especially those employed in the state apparatus-tends to be more supportive of the current Party-state but less supportive of democratic values and institutions; (2) the new middle class's attitudes toward democracy may be accounted for by this class's close ideational and institutional ties with the state, and its perceived socioeconomic wellbeing, among other factors; (3) the lack of support for democracy among the middle class tends to cause this social class to act in favor of the current state but in opposition to democratic changes. The most important political implication is that while China's middle class is not likely to serve as the harbinger of democracy now, its current attitudes toward democracy may change in the future. Such a crucial shift in the middle class's orientation toward democracy can take place, especially when its dependence on the Party-state decreases and perception of its own social and economic statuses turns pessimistic. The key theoretical implication from the findings suggests that the attitudinal and behavioral orientations of the middle class-as a whole and as a part-toward democratic change in late developing countries are contingent upon its relationship with the incumbent state and its perceived social/economic wellbeing, and the middle class's support for democracy in these countries is far from inevitable.
Middle Class Without Democracy
Economic Growth and the Prospects for Democratization in China
AvJie Chen
E-bok
PDF, Engelska, 2013
384 kr
Läs direkt efter köp
What kind of role can the middle class play in potential democratization in such an undemocratic, late developing country as China? To answer this profound political as well as theoretical question, Jie Chen explores attitudinal and behavioral orientation of China''s new middle class to democracy and democratization. Chen''s work is based on a unique set of data collected from a probability-sample survey and in-depth interviews of residents in three major Chinese cities, Beijing, Chengdu and Xi''an--each of which represents a distinct level of economic development in urban China-in 2007 and 2008. The empirical findings derived from this data set confirm that (1) compared to other social classes, particularly lower classes, the new Chinese middle class-especially those employed in the state apparatus-tends to be more supportive of the current Party-state but less supportive of democratic values and institutions; (2) the new middle class''s attitudes toward democracy may be accounted for by this class''s close ideational and institutional ties with the state, and its perceived socioeconomic wellbeing, among other factors; (3) the lack of support for democracy among the middle class tends to cause this social class to act in favor of the current state but in opposition to democratic changes. The most important political implication is that while China''s middle class is not likely to serve as the harbinger of democracy now, its current attitudes toward democracy may change in the future. Such a crucial shift in the middle class''s orientation toward democracy can take place, especially when its dependence on the Party-state decreases and perception of its own social and economic statuses turns pessimistic. The key theoretical implication from the findings suggests that the attitudinal and behavioral orientations of the middle class-as a whole and as a part-toward democratic change in late developing countries are contingent upon its relationship with the incumbent state and its perceived social/economic wellbeing, and the middle class''s support for democracy in these countries is far from inevitable.
Ideology in U.S. Foreign Policy
Case Studies in U.S. China Policy
AvJie Chen
Inbunden, Engelska, 1992
845 kr
Skickas inom 10-15 vardagar
This book provides an alternative theoretical approach to the study of ideology in U.S. foreign policy, emphasizing the importance of ideology in foreign relations. Unlike traditional approaches, which tend to neglect the variability of ideological influence, Chen's approach postulates a two-step causal relationship that explains changes in the strength of ideology and their influence on U.S. foreign policy. Changes in objective conditions cause changes in the strength of ideology, and these changes, in turn, create fluctuations in U.S. foreign policy.Chen explores that causal relationship empirically through detailed case studies of U.S. China policy and also, in his concluding analysis, looks at ideology and recent U.S. policies toward Eastern Europe and the Middle East. This book will be of interest to teachers and students of international relations.
Medical Product Safety Evaluation
Biological Models and Statistical Methods
AvJie Chen,Joseph Heysem. fl.
Häftad, Engelska, 2020
803 kr
Skickas inom 10-15 vardagar
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. The book is designed not only for biopharmaceutical professionals, such as statisticians, safety specialists, pharmacovigilance experts, and pharmacoepidemiologists, who can use the book as self-learning materials or in short courses or training programs, but also for graduate students in statistics and biomedical data science for a one-semester course. Each chapter provides supplements and problems as more readings and exercises.
Allies of the State
China's Private Entrepreneurs and Democratic Change
AvJie Chen,Bruce J. Dickson
Inbunden, Engelska, 2010
412 kr
Skickas inom 10-15 vardagar
Jie Chen and Bruce J. Dickson draw on extensive fieldwork as they explore the extent to which China’s private sector supports democracy, surveying more than 2,000 entrepreneurs in five coastal provinces with over 70 percent of China’s private enterprises.The authors examine who the private entrepreneurs are, how the party-state shapes this group, and what their relationship to the state is. China’s entrepreneurs are closely tied to the state through political and financial relationships, and these ties shape their views toward democracy. While most entrepreneurs favor multi-candidate elections under the current one-party system, they do not support a system characterized by multi-party competition and political liberties, including the right to demonstrate. The key to regime support lies in the capitalists’ political beliefs and their assessment of the government’s policy performance. China’s capitalists tend to be conservative and status-quo oriented, not likely to serve as agents of democratization.This is a valuable contribution not only to the debates over the prospects for democracy in China but also to understanding the process of democratization around the globe.
Robust Model-Based Fault Diagnosis for Dynamic Systems
AvJie Chen,R.J. Patton
Inbunden, Engelska, 1998
3 327 kr
Skickas inom 10-15 vardagar
There is an increasing demand for dynamic systems to become more safe and reliable. This requirement extends beyond the normally accepted safety-critical systems of nuclear reactors and aircraft where safety is paramount important, to systems such as autonomous vehicles and fast railways where the system availability is vital. It is clear that fault diagnosis (including fault detection and isolation, FDI) has been becoming an important subject in modern control theory and practice. For example, the number of papers on FDI presented in many control-related conferences has been increasing steadily. The subject of fault detection and isolation continues to mature to an established field of research in control engineering. A large amount of knowledge on model-based fault diagnosis has been ac cumulated through the literature since the beginning of the 1970s. However, publications are scattered over many papers and a few edited books. Up to the end of 1997, there is no any book which presents the subject in an unified framework. The consequence of this is the lack of "common language", dif ferent researchers use different terminology. This problem has obstructed the progress of model-based FDI techniques and has been causing great concern in research community. Many survey papers have been published to tackle this problem. However, a book which presents the materials in a unified format and provides a comprehensive foundation of model-based FDI is urgently needed.
Popular Political Support in Urban China
AvJie Chen
Inbunden, Engelska, 2004
1 459 kr
Skickas inom 10-15 vardagar
Has the current political system in the People's Republic of China lost its legitimacy in the eyes of the Chinese public? On the basis of three carefully drawn surveys of Beijing residents between 1995 and 1999, the author finds that diffuse support for the current political system—based on attitudes toward institutions and values—remains strong, at least among city-dwellers, though it is gradually declining. Specific support for current political authorities, as measured by evaluations of their performance in major policy domains, is much weaker, with many citizens evaluating the authorities' performance as mediocre.In analyzing the longitudinal data presented here, the author finds that the same set of key sociodemographic attributes and sociopolitical orientations variably influence citizens' attitudes toward the political system and their evaluations of leaders' performance. Further, the study shows that citizens' attitudes toward the system, on the one hand, and their evaluation of incumbents' performance on the other, have different impacts on forms of political participation, such as voting and contacting authorities.
Popular Political Support in Urban China
AvJie Chen
Häftad, Engelska, 2004
337 kr
Skickas inom 5-8 vardagar
Has the current political system in the People's Republic of China lost its legitimacy in the eyes of the Chinese public? On the basis of three carefully drawn surveys of Beijing residents between 1995 and 1999, the author finds that diffuse support for the current political system—based on attitudes toward institutions and values—remains strong, at least among city-dwellers, though it is gradually declining. Specific support for current political authorities, as measured by evaluations of their performance in major policy domains, is much weaker, with many citizens evaluating the authorities' performance as mediocre.In analyzing the longitudinal data presented here, the author finds that the same set of key sociodemographic attributes and sociopolitical orientations variably influence citizens' attitudes toward the political system and their evaluations of leaders' performance. Further, the study shows that citizens' attitudes toward the system, on the one hand, and their evaluation of incumbents' performance on the other, have different impacts on forms of political participation, such as voting and contacting authorities.
Stability of Time-Delay Systems
AvKeqin Gu,Vladimir L. Kharitonovm. fl.
Inbunden, Engelska, 2003
1 113 kr
Skickas inom 10-15 vardagar
This monograph is a self-contained, coherent presentation of the background and progress of the stability of time-delay systems. Focusing on techniques, tools, and advances in numerical methods and optimization algorithms, the authors developed material which, up until now, has been scattered in technical journals and conference proceedings. Special emphasis is placed on systems with uncertainty and stability criteria which can be computationally implemented. The second edition is major update to reflect the state of art in this field greatly expanding on the original material in addition to two new chapters on Systems of Neutral Type and an Introduction to Frequency Domain Method. Requiring only basic knowledge of linear systems and Lyapunov stability theory, Stability of Time-Delay Systems, 2nd ed is accessible to a broad audience of researchers, professional engineers, and graduate students. It may be used for self-study or as a reference; portions of the text may be used in advanced graduate courses and seminars.
Parametric Statistical Change Point Analysis
With Applications to Genetics, Medicine, and Finance
AvJie Chen,Arjun K. Gupta
Inbunden, Engelska, 2011
1 777 kr
Skickas inom 10-15 vardagar
This revised and expanded second edition is an in-depth study of the change point problem from a general point of view, as well as a further examination of change point analysis of the most commonly used statistical models. Change point problems are encountered in such disciplines as economics, finance, medicine, psychology, signal processing, and geology, to mention only several. More recently, change point analysis has been found in extensive applications related to analyzing biomedical imaging data, array Comparative Genomic Hybridization (aCGH) data, and gene expression data. The exposition throughout the work is clear and systematic, with a great deal of introductory material included. Different models are presented in each chapter, including gamma and exponential models, rarely examined thus far in the literature. Extensive examples throughout the text emphasize key concepts and different methodologies used, namely the likelihood ratio criterion as well as the Bayesian and information criterion approaches. New examples of change point analysis in modern molecular biology and other fields such as finance and air traffic control are added in this second edition. Also included are two new chapters on change points in the hazard function and other practical change point models such as the epidemic change point model and a smooth-and-abrupt change point model. An up-to-date comprehensive bibliography and two indices round out the work.
Parametric Statistical Change Point Analysis
With Applications to Genetics, Medicine, and Finance
AvArjun K. Gupta,Jie Chen
E-bok
PDF, Engelska, 2011
2 217 kr
Läs direkt efter köp
This revised and expanded second edition is an in-depth study of the change point problem from a general point of view, as well as a further examination of change point analysis of the most commonly used statistical models. Change point problems are encountered in such disciplines as economics, finance, medicine, psychology, signal processing, and geology, to mention only several. More recently, change point analysis has been found in extensive applications related to analyzing biomedical imaging data, array Comparative Genomic Hybridization (aCGH) data, and gene expression data.
The exposition throughout the work is clear and systematic, with a great deal of introductory material included. Different models are presented in each chapter, including gamma and exponential models, rarely examined thus far in the literature. Extensive examples throughout the text emphasize key concepts and different methodologies used, namely the likelihood ratio criterion as well as the Bayesian and information criterion approaches. New examples of change point analysis in modern molecular biology and other fields such as finance and air traffic control are added in this second edition. Also included are two new chapters on change points in the hazard function and other practical change point models such as the epidemic change point model and a smooth-and-abrupt change point model. An up-to-date comprehensive bibliography and two indices round out the work.
Missing and Modified Data in Nonparametric Estimation
With R Examples
AvJie Chen,Joseph Heysem. fl.
Inbunden, Engelska, 2018
1 797 kr
Skickas inom 10-15 vardagar
This book presents a systematic and unified approach for modern nonparametric treatment of missing and modified data via examples of density and hazard rate estimation, nonparametric regression, filtering signals, and time series analysis. All basic types of missing at random and not at random, biasing, truncation, censoring, and measurement errors are discussed, and their treatment is explained. Ten chapters of the book cover basic cases of direct data, biased data, nondestructive and destructive missing, survival data modified by truncation and censoring, missing survival data, stationary and nonstationary time series and processes, and ill-posed modifications.The coverage is suitable for self-study or a one-semester course for graduate students with a prerequisite of a standard course in introductory probability. Exercises of various levels of difficulty will be helpful for the instructor and self-study.The book is primarily about practically important small samples. It explains when consistent estimation is possible, and why in some cases missing data should be ignored and why others must be considered. If missing or data modification makes consistent estimation impossible, then the author explains what type of action is needed to restore the lost information.The book contains more than a hundred figures with simulated data that explain virtually every setting, claim, and development. The companion R software package allows the reader to verify, reproduce and modify every simulation and used estimators. This makes the material fully transparent and allows one to study it interactively.Sam Efromovich is the Endowed Professor of Mathematical Sciences and the Head of the Actuarial Program at the University of Texas at Dallas. He is well known for his work on the theory and application of nonparametric curve estimation and is the author of Nonparametric Curve Estimation: Methods, Theory, and Applications. Professor Sam Efromovich is a Fellow of the Institute of Mathematical Statistics and the American Statistical Association.
Bionanotechnology: Engineering Concepts and Applications
AvJie Chen,Yiwei Fengm. fl.
Häftad, Engelska, 2022
1 063 kr
Skickas inom 3-6 vardagar
Understand the principles, practices, and applications of bionanotechnology
This hands-on textbook covers key aspects of bionanotechnology from an engineering perspective. The book delves into a wide variety of topics, including materials science, micro/nano fabrication, general physics, fluid flow, electromagnetics, thermodynamics, molecular biology, immunology, biochemistry, and organic chemistry.
Developed from an advanced engineering course taught by its authors, Bionanotechnology: Engineering Concepts and Applications fully explains all of the underlying concepts and shows how that theory can be directly applied in practical applications. Readers will get examples, problem sets, real-world case studies, and engineering design methodologies that illustrate each concept.
The book contains complete discussions on microfluidics, lab-on-a-chip devices, organ-on-a-chip devices, quantum dots, DNA/RNA technology, micro/nano fabrication techniques, the modelling/simulation of microsystems, and bionanotechnology-based biosensors, targeted therapies, and drug delivery systems.
Combines many different bionanotechnology topics into one resourceBased on a course developed and taught by the authors at the University of AlbertaWritten by recognized experts and experienced educators
Bionanotechnology: Engineering Concepts and Applications
AvScott MacKay,Yiwei Fengm. fl.
E-bok
Engelska, 2022
1 283 kr
Läs direkt efter köp
Understand the principles, practices, and applications of bionanotechnology
This hands-on textbook covers key aspects of bionanotechnology from an engineering perspective. The book delves into a wide variety of topics, including materials science, micro/nano fabrication, general physics, fluid flow, electromagnetics, thermodynamics, molecular biology, immunology, biochemistry, and organic chemistry.
Developed from an advanced engineering course taught by its authors, Bionanotechnology: Engineering Concepts and Applications fully explains all of the underlying concepts and shows how that theory can be directly applied in practical applications. Readers will get examples, problem sets, real-world case studies, and engineering design methodologies that illustrate each concept.
The book contains complete discussions on microfluidics, lab-on-a-chip devices, organ-on-a-chip devices, quantum dots, DNA/RNA technology, micro/nano fabrication techniques, the modelling/simulation of microsystems, and bionanotechnology-based biosensors, targeted therapies, and drug delivery systems.
Combines many different bionanotechnology topics into one resourceBased on a course developed and taught by the authors at the University of AlbertaWritten by recognized experts and experienced educators
Medical Product Safety Evaluation
Biological Models and Statistical Methods
AvTze Leung Lai,Joseph Heysem. fl.
E-bok
Engelska, 2018
942 kr
Läs direkt efter köp
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples.
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples.
The book is designed not only for biopharmaceutical professionals, such as statisticians, safety specialists, pharmacovigilance experts, and pharmacoepidemiologists, who can use the book as self-learning materials or in short courses or training programs, but also for graduate students in statistics and biomedical data science for a one-semester course. Each chapter provides supplements and problems as more readings and exercises.
Medical Product Safety Evaluation
Biological Models and Statistical Methods
AvTze Leung Lai,Joseph Heysem. fl.
E-bok
PDF, Engelska, 2018
933 kr
Läs direkt efter köp
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples.
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples.
The book is designed not only for biopharmaceutical professionals, such as statisticians, safety specialists, pharmacovigilance experts, and pharmacoepidemiologists, who can use the book as self-learning materials or in short courses or training programs, but also for graduate students in statistics and biomedical data science for a one-semester course. Each chapter provides supplements and problems as more readings and exercises.
Clinical Trials in the Era of Real-World Evidence
AvJie Chen,Naitee Tingm. fl.
Häftad, Engelska, 2026
1 319 kr
Skickas inom 5-8 vardagar
Integrate RCTs and real-world evidence for stronger regulatory submissionsSince the passage of the 21st Century Cures Act, the landscape of clinical research has transformed dramatically. Today, the integration of real-world data (RWD) and real-world evidence (RWE) with traditional randomized controlled trials (RCTs) is not just innovative - it is essential for modern drug development and regulatory decision-making.This comprehensive volume bridges the methodologies of conventional RCTs and emerging RWE studies, offering systematic approaches for leveraging diverse data sources throughout the clinical development lifecycle. Grounded in regulatory statistics yet forward-looking in scope, the book explores Stein's continuum of study designs - from traditional RCTs to pragmatic trials and observational studies - and demonstrates how RWD can enhance trial feasibility, inform outcome selection, provide external controls for single-arm trials, and strengthen post-approval safety monitoring.Readers will find detailed explorations of: A history of clinical trials, evidence-based medicine, and the regulatory frameworks governing drug approvalTreatment switching and estimands in RWE studiesAdvanced analytical considerations including precision medicine, vaccine effectiveness, safety evaluation, and sensitivity analysisPractical roadmaps for designing robust RWE studiesArtificial intelligence and machine learning in clinical researchDesigned as both a reference and a graduate-level textbook, this book serves clinical researchers such as clinicians and biostatisticians, regulatory professionals, public health scientists, and industry practitioners seeking to harness the power of RWD and RWE to generate credible, actionable evidence for modern medicine.
Clinical Trials in the Era of Real-World Evidence
AvFeinan Lu,Naitee Tingm. fl.
E-bok
PDF, Engelska, 2026
1 642 kr
Läs direkt efter köp
Integrate RCTs and real-world evidence for stronger regulatory submissions
Since the passage of the 21st Century Cures Act, the landscape of clinical research has transformed dramatically. Today, the integration of real-world data (RWD) and real-world evidence (RWE) with traditional randomized controlled trials (RCTs) is not just innovative - it is essential for modern drug development and regulatory decision-making.
This comprehensive volume bridges the methodologies of conventional RCTs and emerging RWE studies, offering systematic approaches for leveraging diverse data sources throughout the clinical development lifecycle. Grounded in regulatory statistics yet forward-looking in scope, the book explores Stein???s continuum of study designs - from traditional RCTs to pragmatic trials and observational studies - and demonstrates how RWD can enhance trial feasibility, inform outcome selection, provide external controls for single-arm trials, and strengthen post-approval safety monitoring.
Readers will find detailed explorations of:
A history of clinical trials, evidence-based medicine, and the regulatory frameworks governing drug approval Treatment switching and estimands in RWE studies Advanced analytical considerations including precision medicine, vaccine effectiveness, safety evaluation, and sensitivity analysis Practical roadmaps for designing robust RWE studies Artificial intelligence and machine learning in clinical research
Designed as both a reference and a graduate-level textbook, this book serves clinical researchers such as clinicians and biostatisticians, regulatory professionals, public health scientists, and industry practitioners seeking to harness the power of RWD and RWE to generate credible, actionable evidence for modern medicine.
Clinical Trials in the Era of Real-World Evidence
AvFeinan Lu,Naitee Tingm. fl.
E-bok
Engelska, 2026
1 630 kr
Läs direkt efter köp
Integrate RCTs and real-world evidence for stronger regulatory submissions Since the passage of the 21st Century Cures Act, the landscape of clinical research has transformed dramatically. Today, the integration of real-world data (RWD) and real-world evidence (RWE) with traditional randomized controlled trials (RCTs) is not just innovative - it is essential for modern drug development and regulatory decision-making. This comprehensive volume bridges the methodologies of conventional RCTs and emerging RWE studies, offering systematic approaches for leveraging diverse data sources throughout the clinical development lifecycle. Grounded in regulatory statistics yet forward-looking in scope, the book explores Stein's continuum of study designs - from traditional RCTs to pragmatic trials and observational studies - and demonstrates how RWD can enhance trial feasibility, inform outcome selection, provide external controls for single-arm trials, and strengthen post-approval safety monitoring. Readers will find detailed explorations of: A history of clinical trials, evidence-based medicine, and the regulatory frameworks governing drug approval Treatment switching and estimands in RWE studies Advanced analytical considerations including precision medicine, vaccine effectiveness, safety evaluation, and sensitivity analysis Practical roadmaps for designing robust RWE studies Artificial intelligence and machine learning in clinical research Designed as both a reference and a graduate-level textbook, this book serves clinical researchers such as clinicians and biostatisticians, regulatory professionals, public health scientists, and industry practitioners seeking to harness the power of RWD and RWE to generate credible, actionable evidence for modern medicine.
Stability of Time-Delay Systems
AvJie Chen,Vladimir L. Kharitonovm. fl.
E-bok
PDF, Engelska, 2012
1 587 kr
Läs direkt efter köp
This monograph is a self-contained, coherent presentation of the background and progress of the stability of time-delay systems. Focusing on techniques, tools, and advances in numerical methods and optimization algorithms, the authors developed material which, up until now, has been scattered in technical journals and conference proceedings. Special emphasis is placed on systems with uncertainty and stability criteria which can be computationally implemented.

The second edition is major update to reflect the state of art in this field greatly expanding on the original material in addition to two new chapters on Systems of Neutral Type and an Introduction to Frequency Domain Method.

Requiring only basic knowledge of linear systems and Lyapunov stability theory, Stability of Time-Delay Systems, 2nd ed is accessible to a broad audience of researchers, professional engineers, and graduate students. It may be used for self-study or as a reference; portions of the text may be used in advanced graduate courses and seminars.
Stability of Time-Delay Systems
AvKeqin Gu,Vladimir L. Kharitonovm. fl.
Häftad, Engelska, 2012
1 224 kr
Skickas inom 10-15 vardagar
This monograph is a self-contained, coherent presentation of the background and progress of the stability of time-delay systems. Focusing on techniques, tools, and advances in numerical methods and optimization algorithms, the authors developed material which, up until now, has been scattered in technical journals and conference proceedings. Special emphasis is placed on systems with uncertainty and stability criteria which can be computationally implemented. The second edition is major update to reflect the state of art in this field greatly expanding on the original material in addition to two new chapters on Systems of Neutral Type and an Introduction to Frequency Domain Method. Requiring only basic knowledge of linear systems and Lyapunov stability theory, Stability of Time-Delay Systems, 2nd ed is accessible to a broad audience of researchers, professional engineers, and graduate students. It may be used for self-study or as a reference; portions of the text may be used in advanced graduate courses and seminars.
Robust Model-Based Fault Diagnosis for Dynamic Systems
AvJie Chen,R.J. Patton
Häftad, Engelska, 2012
3 327 kr
Skickas inom 10-15 vardagar
There is an increasing demand for dynamic systems to become more safe and reliable. This requirement extends beyond the normally accepted safety-critical systems of nuclear reactors and aircraft where safety is paramount important, to systems such as autonomous vehicles and fast railways where the system availability is vital. It is clear that fault diagnosis (including fault detection and isolation, FDI) has been becoming an important subject in modern control theory and practice. For example, the number of papers on FDI presented in many control-related conferences has been increasing steadily. The subject of fault detection and isolation continues to mature to an established field of research in control engineering. A large amount of knowledge on model-based fault diagnosis has been ac cumulated through the literature since the beginning of the 1970s. However, publications are scattered over many papers and a few edited books. Up to the end of 1997, there is no any book which presents the subject in an unified framework. The consequence of this is the lack of "common language", dif ferent researchers use different terminology. This problem has obstructed the progress of model-based FDI techniques and has been causing great concern in research community. Many survey papers have been published to tackle this problem. However, a book which presents the materials in a unified format and provides a comprehensive foundation of model-based FDI is urgently needed.
Robust Model-Based Fault Diagnosis for Dynamic Systems
AvR.J. Patton,Jie Chen
E-bok
PDF, Engelska, 2012
3 948 kr
Läs direkt efter köp
There is an increasing demand for dynamic systems to become more safe and reliable. This requirement extends beyond the normally accepted safety-critical systems of nuclear reactors and aircraft where safety is paramount important, to systems such as autonomous vehicles and fast railways where the system availability is vital. It is clear that fault diagnosis (including fault detection and isolation, FDI) has been becoming an important subject in modern control theory and practice. For example, the number of papers on FDI presented in many control-related conferences has been increasing steadily. The subject of fault detection and isolation continues to mature to an established field of research in control engineering. A large amount of knowledge on model-based fault diagnosis has been ac cumulated through the literature since the beginning of the 1970s. However, publications are scattered over many papers and a few edited books. Up to the end of 1997, there is no any book which presents the subject in an unified framework. The consequence of this is the lack of "common language", dif ferent researchers use different terminology. This problem has obstructed the progress of model-based FDI techniques and has been causing great concern in research community. Many survey papers have been published to tackle this problem. However, a book which presents the materials in a unified format and provides a comprehensive foundation of model-based FDI is urgently needed.
Medical Product Safety Evaluation
Biological Models and Statistical Methods
AvJie Chen,Joseph Heysem. fl.
Inbunden, Engelska, 2018
2 161 kr
Skickas inom 10-15 vardagar
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. The book is designed not only for biopharmaceutical professionals, such as statisticians, safety specialists, pharmacovigilance experts, and pharmacoepidemiologists, who can use the book as self-learning materials or in short courses or training programs, but also for graduate students in statistics and biomedical data science for a one-semester course. Each chapter provides supplements and problems as more readings and exercises.
Parametric Statistical Change Point Analysis
AvA.K. Gupta,Jie Chen
E-bok
PDF, Engelska, 2013
1 136 kr
Läs direkt efter köp
Recently there has been a keen interest in the statistical analysis of change point detec tion and estimation. Mainly, it is because change point problems can be encountered in many disciplines such as economics, finance, medicine, psychology, geology, litera ture, etc. , and even in our daily lives. From the statistical point of view, a change point is a place or time point such that the observations follow one distribution up to that point and follow another distribution after that point. Multiple change points problem can also be defined similarly. So the change point(s) problem is two fold: one is to de cide if there is any change (often viewed as a hypothesis testing problem), another is to locate the change point when there is a change present (often viewed as an estimation problem). The earliest change point study can be traced back to the 1950s. During the fol lowing period of some forty years, numerous articles have been published in various journals and proceedings. Many of them cover the topic of single change point in the means of a sequence of independently normally distributed random variables. Another popularly covered topic is a change point in regression models such as linear regres sion and autoregression. The methods used are mainly likelihood ratio, nonparametric, and Bayesian. Few authors also considered the change point problem in other model settings such as the gamma and exponential.
Complex City: Social and Built Approaches and Methods
AvAlaa El-Habashi,Aliaa Khalil Zidanm. fl.
Inbunden, Engelska, 2022
1 261 kr
Skickas inom 5-8 vardagar
Complex City: Social and Built Approaches and Methods
Social and Built Approaches and Methods
AvAlaa El-Habashi,Aliaa Khalil Zidanm. fl.
Häftad, Engelska, 2023
698 kr
Skickas inom 5-8 vardagar
Overseas Chinese Democracy Movement
Assessing China’s Only Open Political Opposition
AvJie Chen
Inbunden, Engelska, 2019
1 718 kr
Skickas inom 5-8 vardagar
The overseas Chinese democracy movement (OCDM) is one of the world's longest-running and most difficult exile political campaigns. This unique book is a rare and comprehensive account of its trajectory since its beginnings in the early 1980s, examining its shifting operational environment and the diversification of its activities, as well as characterizing its distinctive features in comparison to other exile movements.Chen Jie takes an empirical approach to the history of the OCDM, drawing on extensive primary sources and his own significant field research, including interviews with major dissident figures. He explores the changing roles of activists since the events of Tiananmen Square and the movement's subsequent heyday, highlighting the diverse positions occupied today as a result of internal division and evolving geopolitical circumstances. Using the analytical framework of exile politics, Chen also examines such issues as China's relationship with Taiwan and the implications of the expanding global Chinese diaspora.Academics and postgraduate students studying Chinese politics and international relations, as well as those with an interest in diaspora studies, will find this book invaluable. It will also provide important understanding of Chinese exiles and activists to government officials and those working in international political foundations, funding bodies and human rights organisations.

Jie Chen – författare

Middle Class Without Democracy

A Middle Class Without Democracy

A Middle Class Without Democracy

Middle Class Without Democracy

Ideology in U.S. Foreign Policy

Medical Product Safety Evaluation

Allies of the State

Robust Model-Based Fault Diagnosis for Dynamic Systems

Popular Political Support in Urban China

Popular Political Support in Urban China

Stability of Time-Delay Systems

Parametric Statistical Change Point Analysis

Parametric Statistical Change Point Analysis

Missing and Modified Data in Nonparametric Estimation

Bionanotechnology: Engineering Concepts and Applications

Bionanotechnology: Engineering Concepts and Applications

Medical Product Safety Evaluation

Medical Product Safety Evaluation

Clinical Trials in the Era of Real-World Evidence

Clinical Trials in the Era of Real-World Evidence

Clinical Trials in the Era of Real-World Evidence

Stability of Time-Delay Systems

Stability of Time-Delay Systems

Robust Model-Based Fault Diagnosis for Dynamic Systems

Robust Model-Based Fault Diagnosis for Dynamic Systems

Medical Product Safety Evaluation

Parametric Statistical Change Point Analysis

Complex City: Social and Built Approaches and Methods

Complex City: Social and Built Approaches and Methods

Overseas Chinese Democracy Movement