John H. Zhang – författare & böcker

Primer on Cerebrovascular Diseases

Inbunden, Engelska, 2017

1 468 kr

Skickas inom 10-15 vardagar

Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner.

Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more.

2018 BMA Medical Book Awards Highly Commended in Neurology.

Provides concise chapters on topics in cerebral blood flow and metabolism, pathogenesis of cerebrovascular disorders, diagnostic testing, and management in a comprehensive and accessible format Written by international leading authorities on cerebral vasculature Provides up-to-date information on practical applications of basic research and the main clinical issues facing the community, such as axonal transport and proteomics

Primer on Cerebrovascular Diseases

AvJohn H. Zhang,Midori Yenarim. fl.

E-bok

Engelska, 2017

1 632 kr

Läs direkt efter köp

Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner.Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more.2018 BMA Medical Book Awards Highly Commended in Neurology.- Provides concise chapters on topics in cerebral blood flow and metabolism, pathogenesis of cerebrovascular disorders, diagnostic testing, and management in a comprehensive and accessible format- Written by international leading authorities on cerebral vasculature- Provides up-to-date information on practical applications of basic research and the main clinical issues facing the community, such as axonal transport and proteomics

Translational Stroke Research

From Target Selection to Clinical Trials

AvPaul A. Lapchak,John H. Zhang

Inbunden, Engelska, 2012

2 171 kr

Skickas inom 10-15 vardagar

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Translational Stroke Research

From Target Selection to Clinical Trials

AvJohn H. Zhang,Paul A. Lapchak

E-bok

PDF, Engelska, 2012

2 741 kr

Läs direkt efter köp

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Metal Ion in Stroke

AvYang V. Li,John H. Zhang

Inbunden, Engelska, 2012

2 236 kr

Skickas inom 10-15 vardagar

Stroke is a major cause of death and disability in the U.S. and worldwide. A variety of pathophysiologic episodes or cellular medications occur following a stroke, and knowledge of these aftermath events can lead to potential therapeutic strategies that may reverse or attenuate stroke injury. Cellular events that occur following stroke include the excessive releases of excitatory amino acids, alterations in the genomic responses, mitochondrial injury producing reactive oxygen and nitrogen species (ROS), and secondary injury, often in the setting of reperfusion.

Metal Ion in Stroke

AvJohn H. Zhang,Yang V. Li

E-bok

PDF, Engelska, 2012

2 741 kr

Läs direkt efter köp

Stroke is a major cause of death and disability in the U.S. and worldwide. A variety of pathophysiologic episodes or cellular medications occur following a stroke, and knowledge of these aftermath events can lead to potential therapeutic strategies that may reverse or attenuate stroke injury. Cellular events that occur following stroke include the excessive releases of excitatory amino acids, alterations in the genomic responses, mitochondrial injury producing reactive oxygen and nitrogen species (ROS), and secondary injury, often in the setting of reperfusion.

Innate Tolerance in the CNS

Translational Neuroprotection by Pre- and Post-Conditioning

AvJeffrey M. Gidday,Miguel A. Perez-Pinzonm. fl.

Inbunden, Engelska, 2012

2 236 kr

Skickas inom 10-15 vardagar

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

Innate Tolerance in the CNS

Translational Neuroprotection by Pre- and Post-Conditioning

AvJohn H. Zhang,Miguel A. Perez-Pinzonm. fl.

E-bok

PDF, Engelska, 2012

2 822 kr

Läs direkt efter köp

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for preconditioning-induced tolerance will help in the design novel pharmacological approaches for neuroprotection. While stroke and many other brain injuries are not predictable, in some populations (e.g., metabolic syndrome, patients undergoing carotid endarterectomy, aneurysm clipping, or with recent TIAs) the risk for stroke is identifiable and significant, and preconditioning may represent a useful strategy for neuroprotection. For unpredictable injuries, post-conditioning the brain – or inducing endogenous protective mechanisms after the initial injury – can also abrogate the extent of injury. Finally, remote pre- and post-conditioning methods have been developed in animals, and are now being tested in clinical trials, wherein a brief, noninjurious stress to a noncerebral tissue (i.e., skeletal muscle) can provide protection to the CNS and thereby allows clinicians the opportunity to circumvent concerns regarding the direct preconditioning of neurological tissues.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

AvJun Chen,Xiaoming Hum. fl.

Inbunden, Engelska, 2013

1 678 kr

Skickas inom 10-15 vardagar

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

AvJohn H. Zhang,Mary Stenzel-Poorem. fl.

E-bok

PDF, Engelska, 2013

2 036 kr

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Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.

White Matter Injury in Stroke and CNS Disease

AvSelva Baltan,S. Thomas Carmichaelm. fl.

Inbunden, Engelska, 2013

2 236 kr

Skickas inom 10-15 vardagar

White matter injury can result from both ischemic and hemorrhagic stroke as well as a host of other CNS diseases and conditions such as neonatal injuries, neurodegenerative disorders including Alzheimer's disease, traumatic brain injuries, carbon monoxide poisoning, and drug or alcohol overdoses. The extent of white matter injury is extremely important to patient outcomes. Several recent technological developments including advanced neuroimaging and the breeding of new rodent models of white matter injury have provided growing insight into initial damage and repair after a stroke or other damaging event. The proposed book will be the first to provide a systematic expert summary of normal white matter morphology as well as white matter injury following stroke and other CNS injuries.

White Matter Injury in Stroke and CNS Disease

AvJohn H Zhang,Guohua Xim. fl.

E-bok

PDF, Engelska, 2013

2 822 kr

Läs direkt efter köp

White matter injury can result from both ischemic and hemorrhagic stroke as well as a host of other CNS diseases and conditions such as neonatal injuries, neurodegenerative disorders including Alzheimer''s disease, traumatic brain injuries, carbon monoxide poisoning, and drug or alcohol overdoses. The extent of white matter injury is extremely important to patient outcomes. Several recent technological developments including advanced neuroimaging and the breeding of new rodent models of white matter injury have provided growing insight into initial damage and repair after a stroke or other damaging event. The proposed book will be the first to provide a systematic expert summary of normal white matter morphology as well as white matter injury following stroke and other CNS injuries.

Translational Stroke Research

From Target Selection to Clinical Trials

AvPaul A. Lapchak,John H. Zhang

Häftad, Engelska, 2016

2 156 kr

Skickas inom 10-15 vardagar

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research.

Metal Ion in Stroke

AvYang V. Li,John H. Zhang

Häftad, Engelska, 2016

2 156 kr

Skickas inom 10-15 vardagar

Cellular events that occur following stroke include the excessive releases of excitatory amino acids, alterations in the genomic responses, mitochondrial injury producing reactive oxygen and nitrogen species (ROS), and secondary injury, often in the setting of reperfusion.

Innate Tolerance in the CNS

Translational Neuroprotection by Pre- and Post-Conditioning

AvJeffrey M. Gidday,Miguel A. Perez-Pinzonm. fl.

Häftad, Engelska, 2016

2 221 kr

Skickas inom 10-15 vardagar

Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

AvJun Chen,Xiaoming Hum. fl.

Häftad, Engelska, 2016

1 667 kr

Skickas inom 10-15 vardagar

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.

White Matter Injury in Stroke and CNS Disease

AvSelva Baltan,S. Thomas Carmichaelm. fl.

Häftad, Engelska, 2016

2 845 kr

Skickas inom 5-8 vardagar

White matter injury can result from both ischemic and hemorrhagic stroke as well as a host of other CNS diseases and conditions such as neonatal injuries, neurodegenerative disorders including Alzheimer's disease, traumatic brain injuries, carbon monoxide poisoning, and drug or alcohol overdoses. The extent of white matter injury is extremely important to patient outcomes. Several recent technological developments including advanced neuroimaging and the breeding of new rodent models of white matter injury have provided growing insight into initial damage and repair after a stroke or other damaging event. The proposed book will be the first to provide a systematic expert summary of normal white matter morphology as well as white matter injury following stroke and other CNS injuries.

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 2

AvJun Chen,Xiao-Ming Xum. fl.

Häftad, Engelska, 2016

1 225 kr

Skickas inom 10-15 vardagar

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 1

AvJun Chen,Xiao-Ming Xum. fl.

Häftad, Engelska, 2016

1 225 kr

Skickas inom 10-15 vardagar

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 1

AvJun Chen,Xiao-Ming Xum. fl.

Inbunden, Engelska, 2012

1 678 kr

Skickas inom 10-15 vardagar

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 1

AvJohn H. Zhang,Zao C. Xum. fl.

E-bok

Engelska, 2012

1 565 kr

Läs direkt efter köp

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.

Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 2

AvJun Chen,Xiao-Ming Xum. fl.

Inbunden, Engelska, 2012

1 678 kr

Skickas inom 10-15 vardagar

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used. Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 2

AvJohn H. Zhang,Zao C. Xum. fl.

E-bok

Engelska, 2012

1 565 kr

Läs direkt efter köp

The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries. Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system. Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury. Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.

Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.

Subarachnoid Hemorrhage

Neurological Care and Protection

AvRobert D. Martin,Warren Bolingm. fl.

Inbunden, Engelska, 2019

1 567 kr

Skickas inom 10-15 vardagar

This book highlights the latest developments in acute and delayed neurovascular injury studies including delayed cerebral vasospasm, early brain injury, micro-circulation compromise, spreading cortical depolarization, neuroinflammation, and long-term cognitive dysfunctions after subarachnoid hemorrhage.

Subarachnoid Hemorrhage

Neurological Care and Protection

AvJohn H. Zhang,Gang Chenm. fl.

E-bok

Engelska, 2019

1 879 kr

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This book highlights the latest developments in acute and delayed neurovascular injury studies including delayed cerebral vasospasm, early brain injury, micro-circulation compromise, spreading cortical depolarization, neuroinflammation, and long-term cognitive dysfunctions after subarachnoid hemorrhage. About 32 chapters cover original presentations from the 14th international conference on neurovascular events after subarachnoid hemorrhage, held in Los Angeles in October 2017. Neurosurgeons, neurologists, and neuro-ICU practitioners discuss clinical observations, new pilot treatments, clinical trials, academic and industrial interactions, including surgical and endovascular approaches, brain injury monitoring, new developments in brain imaging, ICU management, early brain injury scales and management, counter cortical depolarization management and anti-inflammation management. In addition, animal models used to study acute and delayed neurovascular events, the basic mechanisms of vascular, neuronal, and CSF physiology, new experimental treatment strategies, new frontiers in the treatment of neurovascular injuries, and new research directions are discussed.

Cerebral Ischemic Reperfusion Injuries (CIRI)

Bench Research and Clinical Implications

AvWeijian Jiang,Wengui Yum. fl.

Häftad, Engelska, 2018

1 121 kr

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This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine YanQu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Animal Models of Acute Neurological Injury

AvJun Chen,Zao C. Xum. fl.

Inbunden, Engelska, 2019

1 678 kr

Skickas inom 10-15 vardagar

The second edition continues to offer the research community tested approaches for this area of investigation. As with the first edition, top experts have developed and contributed these animal models.

Animal Models of Acute Neurological Injury

AvJohn H. Zhang,Xiao Ming Xum. fl.

E-bok

Engelska, 2019

2 036 kr

Läs direkt efter köp

Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community tested approaches for this area of investigation.

As with the first edition, top experts have developed and contributed these animal models. The book’s focus remains hands-on, practical applications of the models, rather than a theoretical approach. Each chapter contains a proven procedure enhanced by clear figures, illustrations, or videos. This new edition presents its readily reproducible protocols with clarity and consistency to best aid neuroscientists and neurobiologists. As with the first edition, the second edition is comprehensive and cutting-edge. Animal Models of Acute Neurological Injuries, Second Edition, is an ideal guide for research professionals, at all stages of their careers, who wish to pursue this vital course of study with the proficiency and precision required by the field.

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

AvJun Chen,Jian Wangm. fl.

Inbunden, Engelska, 2019

1 456 kr

Skickas inom 10-15 vardagar

The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer's, Parkinson's, and others.

Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

AvJohn H. Zhang,Ling Weim. fl.

E-bok

Engelska, 2019

1 722 kr

Läs direkt efter köp

The blood-brain-barrier serves to encapsulate and protect the central nervous system, but it also presents a major barricade to therapeutic drug delivery. Poor penetration is the most common hurdle to translating a promising experimental therapy that uses invasive delivery methods to a clinically useful application. In the last 10 years, intranasal delivery of various therapeutic compounds including small chemicals, large proteins, and even stem cells has proven to be very effective in bypassing the blood-brain-barrier and has led to some important advances in translational research for stroke and other neurological diseases. The proposed book will bring together reports from various labs around the world who have had successes in pre-clinical studies of intranasal therapies for various diseases including adult and perinatal stroke, Alzheimer''s, Parkinson''s, and others.