John Pollard – författare

Seers, Shrines and Sirens (1965) surveys the history of Greek religion during the great formative and revolutionary era of the sixth century BC. It treats, among other subjects, the rise to prominence of the Delphic oracle, the growth of religious festivals and mysteries, the worship of Dionysus, including the development of the drama and appearance of the Orphic and Pythagorean sects. The sixth century was above all a time when prophets, supermen and sibyls flourished and their impact is discussed in detail.

Seers, Shrines and Sirens (1965) surveys the history of Greek religion during the great formative and revolutionary era of the sixth century BC. It treats, among other subjects, the rise to prominence of the Delphic oracle, the growth of religious festivals and mysteries, the worship of Dionysus, including the development of the drama and appearance of the Orphic and Pythagorean sects. The sixth century was above all a time when prophets, supermen and sibyls flourished and their impact is discussed in detail.

John Pollard''s book surveys the relationship between Catholicism and the process of change in Italy from Unification to the present day. Central to the book is the complex set of relationships between traditional religion and the forces of change. In a broad sweep, Catholicism in Modern Italy looks at the cultural, social, political and economic aspects of the Catholic church and its relationship to the different experiences across Italy over this dramatic period of change and ''modernisation''.

John Pollard''s book surveys the relationship between Catholicism and the process of change in Italy from Unification to the present day. Central to the book is the complex set of relationships between traditional religion and the forces of change. In a broad sweep, Catholicism in Modern Italy looks at the cultural, social, political and economic aspects of the Catholic church and its relationship to the different experiences across Italy over this dramatic period of change and ''modernisation''.

When a young American draft dodger from the Vietnam War disappears, his anxious parents seek the help of a Buffalo, New York, investigation company. The last coded postcard they received from their son indicated that he was hiding out in Afghanistan. The investigator photographs two bearded American young men camped in Kabul arguing with a better-dressed Englishman, but neither is the missing son. The trail goes cold. Thirty-five years later, a western Australian friend of the widowed mother uncovers the names of an Australian couple who were camped in Kabul at the time and might be able to provide clues to the young man''s disappearance. The search is renewed, taking the investigators to Pakistan, the Indian Himalayas, the red-light area of Bangkok, and to the neighboring Laos.

Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents thatmay have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR.

In this book we will review a series of important topics that are of great interest to a broad range of academic, industrial and clinical researchers, including  the basic science of the DDR, its role in tumorigenesis and in dictating response to DNA damaging drugs and IR. Additionally, we will focus on the several proteins that have been targeted in attempts to provide drug candidates, each of which appear to have quite distinct profiles and could represent very different opportunities to provide patient benefit.