John T. Hancock – författare

Written primarily for students embarking on an undergraduate bioscience degree, this primer provides a clear introduction to the main aspects of cell signalling in biological systems, demystifying the subject for those new to the field. The primer provides an overview of cell signalling and highlights its importance in all organisms, before going on to describe the main components of cell signalling and examples of signal transduction pathways. The discussion then progresses on to key physiological conditions in which cell signalling has an instrumental role: cancer, apoptosis and diabetes. After getting to grips with the fundamentals of the subject, Cell Signalling opens a discussion on the future of the discipline, including how manipulation of cell signalling pathways is seen as the biggest target for the pharmaceutical industry, and how crop diseases, plant survival during stress, and post-harvest storage are all influenced by cell signalling pathways.Cell Signalling is supported by online resources and is available for students and institutions to purchase in a variety of formats. The e-book offers a mobile experience and convenient access along with functionality tools, navigation features and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks The online resources include:For students:- Self-test questionsFor registered adopters of the book:· Figures from the book, available to download

Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impact of environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular and intracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource CentreThe Online Resource Centre to accompany Cell Signalling features:For students:- Links to useful websitesFor registered adopters of the text:- Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book- Figures from the book in electronic format for use in lectures

Why Elephants Cry is a fascinating frolic through the literature and evidence surrounding the use of unusual behavior of animals to measure and predict the environment. The role of animals, from the smallest ant to the biggest elephant, as predictors of environmental changes is framed around the climate crisis, which highlights the increasingly important part that animals will have to play in the future. Renowned biologist Professor John T. Hancock collects anecdotal stories and myths along with scientific evidence, demonstrating that observation of animals can be of tangible use. He looks at the measurement of the air temperature using ants, crickets and snakes, and goes on to assess the evidence that the observation of a wide range of animals can predict the weather or the imminent eruption of volcanoes and earthquakes. Evidence of animals being able to predict lunar and solar events, such as lunar cycles and the Northern Lights, is also considered. This is the only time that all this literature has been brought together in one place, a fascinating reference for anybody interested in animals and the environment. The book is also an ideal supplementary textbook for students studying animal behaviour.

Why Elephants Cry is a fascinating frolic through the literature and evidence surrounding the use of unusual behavior of animals to measure and predict the environment. The role of animals, from the smallest ant to the biggest elephant, as predictors of environmental changes is framed around the climate crisis, which highlights the increasingly important part that animals will have to play in the future. Renowned biologist Professor John T. Hancock collects anecdotal stories and myths along with scientific evidence, demonstrating that observation of animals can be of tangible use. He looks at the measurement of the air temperature using ants, crickets and snakes, and goes on to assess the evidence that the observation of a wide range of animals can predict the weather or the imminent eruption of volcanoes and earthquakes. Evidence of animals being able to predict lunar and solar events, such as lunar cycles and the Northern Lights, is also considered. This is the only time that all this literature has been brought together in one place, a fascinating reference for anybody interested in animals and the environment. The book is also an ideal supplementary textbook for students studying animal behaviour.

Animal Welfare in a Pandemic explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. During the height of the pandemic, a range of animals were infected, and many died, but this was hard to predict, even using up-to-date bioinformatics. Lockdowns around the world had, and continue to have, a major effect on animals’ welfare, influencing pet ownership and care, as well as impacting on the work of conservation institutes due to the lack of visitors and funding and lack of tourist presence in the wild which impacted on anti-poaching efforts. Some of the vast amount of personal protection equipment (PPE) that was distributed was discarded, creating both dangers and occasional opportunities for wild animals. With the rollout of human vaccines, some countries started developing animal vaccines, only some of which were deployed. In summary, the pandemic had a wide-ranging influence on animal welfare around the world. This is reviewed to highlight what can be learned to protect and enhance animal welfare in future epidemics/pandemics, and contribute to a genuinely One Health approach where the health and welfare of both humans and animals are considered holistically.This book is authored by members of the University of the West of England, Bristol, who span a range of expertise in Biological Sciences, Social Sciences, Animal Welfare, and Ethics.

Animal Welfare in a Pandemic explores the impact of COVID-19 on a wide array of animals, from those in the wild to companion and captive animals. During the height of the pandemic, a range of animals were infected, and many died, but this was hard to predict, even using up-to-date bioinformatics. Lockdowns around the world had, and continue to have, a major effect on animals’ welfare, influencing pet ownership and care, as well as impacting on the work of conservation institutes due to the lack of visitors and funding and lack of tourist presence in the wild which impacted on anti-poaching efforts. Some of the vast amount of personal protection equipment (PPE) that was distributed was discarded, creating both dangers and occasional opportunities for wild animals. With the rollout of human vaccines, some countries started developing animal vaccines, only some of which were deployed. In summary, the pandemic had a wide-ranging influence on animal welfare around the world. This is reviewed to highlight what can be learned to protect and enhance animal welfare in future epidemics/pandemics, and contribute to a genuinely One Health approach where the health and welfare of both humans and animals are considered holistically.This book is authored by members of the University of the West of England, Bristol, who span a range of expertise in Biological Sciences, Social Sciences, Animal Welfare, and Ethics.

Human-animal interactions are often a significant part of our experience in sport and recreational settings. Animals contribute to the quality of these environments as well as our subjective leisure experience, but coexistence can also provide challenges. Starting from the smallest nematode and working up to bears and alligators, this book explores the impact of animals in this arena, discussing how animal behaviour impacts sport and recreation, often positively and sometimes negatively, and, in turn, how humans impact animals in these spaces. Sports and leisure facilities around the world invest significantly in managing interactions with animals to support the quality of recreational experience and the health of both human and nonhuman animals. Bringing together the expertise of the authors in biology, animal behaviour, anthrozoology and psychology, this book discusses ways to encourage, or discourage, animals in sports and leisure settings, whilst always observing best possible welfare and conservation practice. The text is supported by reference to news and media outlets as well as scientific literature.In exploring our relationships with animals in areas highly managed by humans, this book aims to progress how facilities can be improved. It also adopts a One World lens encouraging us to interrogate our preconceived ideas about the animals with which we share these spaces and ultimately hopes that, with better understanding, animals will be treated with respect and wonder rather than seen as a source of conflict.

Human-animal interactions are often a significant part of our experience in sport and recreational settings. Animals contribute to the quality of these environments as well as our subjective leisure experience, but coexistence can also provide challenges. Starting from the smallest nematode and working up to bears and alligators, this book explores the impact of animals in this arena, discussing how animal behaviour impacts sport and recreation, often positively and sometimes negatively, and, in turn, how humans impact animals in these spaces. Sports and leisure facilities around the world invest significantly in managing interactions with animals to support the quality of recreational experience and the health of both human and nonhuman animals. Bringing together the expertise of the authors in biology, animal behaviour, anthrozoology and psychology, this book discusses ways to encourage, or discourage, animals in sports and leisure settings, whilst always observing best possible welfare and conservation practice. The text is supported by reference to news and media outlets as well as scientific literature.In exploring our relationships with animals in areas highly managed by humans, this book aims to progress how facilities can be improved. It also adopts a One World lens encouraging us to interrogate our preconceived ideas about the animals with which we share these spaces and ultimately hopes that, with better understanding, animals will be treated with respect and wonder rather than seen as a source of conflict.

This volume explores the scope of the cellular redox analysis and the importance of not being limited by frequently changing and evolving technology. The chapters in this book cover a wide range of topics such as redox components in animal and plant cells and the role of reactive oxygen species, reactive nitrogen species, and hydrogen sulphide in cell signaling; measuring modifications using Flow Cytometry, ELISA assays, and Western blot analysis; measurement of oxidative stress in mitochondira and biological systems; and the use of the genetically encoded fluorescent probe HyPer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and informative, Redox-Mediated Signal Transduction: Methods and Protocols, Second Edition is a valuable resource for both novice and expert researchers who want to expand their studies into new areas and new systems in the evolving redox field.

Once believed to be involved mainly with energetics, including the production of ATP, knowledge of the role of redox in the control of cellular activity has been expanded over recent years. In Redox-Mediated Signal Transduction: Methods and Protocols, experienced researchers with backgrounds in both the plant and animal sciences contribute timely methods and techniques that can be used to study this important aspect of biology. Beginning with an overview and methods for measuring compounds that affect redox and the redox state of cells, the book continues with reviews of the use of GFP and its derivatives, methods to study the impact of changing redox on proteins, and methods to study the exact molecular changes that may underlie the mechanisms of action of altering redox, among other subjects. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include step-by-step, readily reproducible protocols, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and easy to use, Redox-Mediated Signal Transduction: Methods and Protocols is an ideal reference for those who wish to enter this exciting area of research as well as for those who simply wish for a more thorough understanding of the dramatic impact of redox in the control of cellular function.

Once believed to be involved mainly with energetics, including the production of ATP, knowledge of the role of redox in the control of cellular activity has been expanded over recent years. In Redox-Mediated Signal Transduction: Methods and Protocols, experienced researchers with backgrounds in both the plant and animal sciences contribute timely methods and techniques that can be used to study this important aspect of biology. Beginning with an overview and methods for measuring compounds that affect redox and the redox state of cells, the book continues with reviews of the use of GFP and its derivatives, methods to study the impact of changing redox on proteins, and methods to study the exact molecular changes that may underlie the mechanisms of action of altering redox, among other subjects. As a volume in the highly successful Methods in Molecular Biology™ series, chapters include step-by-step, readily reproducible protocols, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and easy to use, Redox-Mediated Signal Transduction: Methods and Protocols is an ideal reference for those who wish to enter this exciting area of research as well as for those who simply wish for a more thorough understanding of the dramatic impact of redox in the control of cellular function.