Jonathan A. Cook – författare

An Introduction to clinical trials is a concise step-by-step guide to the principles and practices of clinical trials for those studying clinical trials or new to working on one. Clinical trials are critical to the progress of medicine and improving healthcare, as they evaluate whether new treatments and interventions work. They are also complex, multidisciplinary projects that integrate science, ethics, and legal requirements in the conduct of medical research. Starting with the research question, An Introduction to clinical trials explains study design, sample size determination, study set-up, study conduct, statistical analysis, and dissemination of the results. The book primarily focusses on randomised controlled trials as the "ultimate" clinical trial. It demystifies the terminology used in clinical trials research and presents the underlying scientific and statistical concepts. Real-life examples are used throughout to bring concepts to life.Written by an experienced medical statistician, An Introduction to clinical trials will benefit readers of all backgrounds, from postgraduate and medical students, trainee doctors and healthcare professionals to others working on clinical trials in a professional capacity. This book aims to help readers gain a fuller and more rounded understanding of clinical trials.

This valuable new addition to Melville studies offers a ground-breaking interpretation of Melville's last published novel, one of the most complex texts in American literature and a work that has long been noted for the divergent critical views it has elicited. Reading the novel as a generic hybrid of narrative satire and apolyptic vision, Cook situates the novel in its implicit theological, historical, and biographical contexts: he examines the novel's relation to Melville's heterodox ideas of the deity, to the increasingly commercialized cultural milieu of antebellum America, and to Melville's own life and literary career. Uncovering a wealth of new data on the novel's satirical applications, including its covert use of Melville's friends and family for character models, Cook offers a compelling reading of The Confidence-Man - one that is sure to influence our future conception of its creator.

Visionary of the Word brings together the latest scholarship on Herman Melville’s treatment of religion across his long career as a writer of fiction and poetry. The volume suggests the broad range of Melville’s religious concerns, including his engagement with the denominational divisions of American Christianity, his dialogue with transatlantic currents in nineteenth-century religious thought, his consideration of theological and philosophical questions related to the problem of evil and determinism versus free will, and his representation of the global contact among differing faiths and cultures. These essays constitute a capacious response to the many avenues through which Melville interacted with religious faith, doubt, and secularization throughout his career, advancing our understanding of Melville as a visionary interpreter of religious experience who remains resonant in our own religiously complex era.

In Inscrutable Malice, Jonathan A. Cook expertly illuminates Melville's abiding preoccupation with the problem of evil and the dominant role of the Bible in shaping his best-known novel. Drawing on recent research in the fields of biblical studies, the history of religion, and comparative mythology, Cook provides a new interpretation of Moby-Dick that places Melville's creative adaptation of the Bible at the center of the work.Cook identifies two ongoing concerns in the narrative in relation to their key biblical sources: the attempt to reconcile the goodness of God with the existence of evil, as dramatized in the book of Job; and the discourse of the Christian end-times involving the final destruction of evil, as found in the apocalyptic books and eschatological passages of the Old and New Testaments.With his detailed reading of Moby-Dick in relation to its most important source text, Cook greatly expands the reader's understanding of the moral, religious, and mythical dimensions of the novel. Both accessible and erudite, Inscrutable Malice will appeal to scholars, students, and enthusiasts of Melville's classic whaling narrative.

In Inscrutable Malice, Jonathan A. Cook expertly illuminates Melville's abiding preoccupation with the problem of evil and the dominant role of the Bible in shaping his best-known novel. Drawing on recent research in the fields of biblical studies, the history of religion, and comparative mythology, Cook provides a new interpretation of Moby-Dick that places Melville's creative adaptation of the Bible at the center of the work.Cook identifies two ongoing concerns in the narrative in relation to their key biblical sources: the attempt to reconcile the goodness of God with the existence of evil, as dramatized in the book of Job; and the discourse of the Christian end-times involving the final destruction of evil, as found in the apocalyptic books and eschatological passages of the Old and New Testaments.With his detailed reading of Moby-Dick in relation to its most important source text, Cook greatly expands the reader's understanding of the moral, religious, and mythical dimensions of the novel. Both accessible and erudite, Inscrutable Malice will appeal to scholars, students, and enthusiasts of Melville's classic whaling narrative.

Shedding new light on both classic and lesser-known works in the Melville canon with particular attention to the author's literary use of the Bible, Neither Believer Nor Infidel examines the debate between religious skepticism and Christian faith that infused Herman Melville's writings following Moby-Dick. Jonathan A. Cook's study is the first to focus on the decisive role of faith and doubt in Melville's writings following his mid-career turn to shorter fiction, and still later to poetry, as a result of the commercial failures of Moby-Dick and Pierre. Nathaniel Hawthorne claimed that Melville "can neither believe nor be comfortable in his unbelief," a remark that encapsulates an essential truth about Melville's attitude to Christianity. Like many of his Victorian contemporaries, Melville spent his literary career poised between an intellectual rejection of Christian dogma and an emotional attachment to the consolations of non-dogmatic Christian faith. Accompanying this ambivalence was a lifelong devotion to the text of the King James Bible as both moral sourcebook and literary template. Following a biographical overview of skeptical influences and manifestations in Melville's early life and career, Cook examines the evidence of religious doubt and belief in "Bartleby, the Scrivener," "Cock-a-Doodle-Doo!," "The Encantadas," Israel Potter, Battle-Pieces, Timoleon, and Billy Budd. Accessible for both the general reader and the scholar, Neither Believer Nor Infidel clarifies the ambiguities of Melville's pervasive use of religion in his fiction and poetry. In analyzing Melville's persistent oscillation between metaphysical rebellion and attenuated belief, Cook elucidates both well-known and under-appreciated works.