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Generalized anxiety disorder (GAD) and major depression (MD) form the largest group of common mental disorders. These two conditions often occur together, and emerging evidence suggests several similarities between them. As we move toward revising the Diagnostic and Statistical Manual of Mental Disorders for DSM-V, Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V explores the nosologic relationship between GAD and MD. In this comprehensive manual, more than 45 contributors cover a wide range of empirical and conceptual issues that face clinicians and researchers working with GAD and MD today.
This book acts as a guidepost for the entire DSM process. It reviews recent scientific advances in our understanding of the interrelationship between GAD and MD, summarizes the body of evidence into a few broad conclusions, and reflects on the implications of these findings for future nosologic efforts. The contributing authors review empirical data from a variety of perspectives-including genetics, biology, treatment, development, course, predictors, disability, and psychosocial stressors—and then integrate results from research on all these diverse validators to come up with a single "bottom-line" recommendation regarding the relationship between GAD and MD. In addition, the book considers conceptual issues, such as criteria for results from validators, the relevance of results on symptoms of anxiety and depression, weights of different classes of validators, and the rules for assigning disorders into categories. And finally, it addresses the question of what new kinds of data could be gathered that would help to clarify the relationship between MD and GAD more definitively. Each chapter includes tables, charts, and references to enhance the evidence presented on such diverse topics as: • A thorough review of the genetics of GAD and MD• The role of psychotropics in distinguishing between GAD and MD• Biological and treatment aspects of GAD and MD• Psychometric aspects of GAD and MD• Childhood risk factors associated with GAD and MD• Common mental disorders across cultures
Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V develops operationalized criteria for nosologic decisions that enable clinicians to bridge the gap between data to diagnostic recommendations. Not only does the methodology of investigating an active interchange between empirical and conceptual perspectives shed new light on the relationship between GAD and MD, but it also carries implications for the rest of DSM-V.
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Psychiatric Genetics is a concise reference that presents the complexities of this dynamic field in a clearly written, easily accessible format, with numerous tables and illustrations. Ten expert contributors offer a fascinating view of psychiatric genetics in a text that is thorough and scholarly yet also succinct and accessible.
The introduction summarizes the field''s four distinct paradigms -- and their interrelationships -- that help us understand the role of genetic factors in the etiology of psychiatric disorders: basic genetic epidemiology, which demonstrates heritability; advanced genetic epidemiology, which explores the nature and mode of action of these genetic risk factors; gene finding, which enables us to infer the probability that a locus in the genomic region under investigation contributes to psychiatric disorder liability; and molecular genetics, which traces the biological mechanisms by which the DNA variant identified using gene finding methods contributes to the disorder itself.
Psychiatric Genetics illustrates the importance of Appreciating the complex field of psychiatric genetics -- Presents the major conceptual and statistical issues in psychiatric genetics, including many of the basic principles of both genetic epidemiology and gene finding, as well as a brief review of DNA itself. Detailing the results for one disorder where substantial progress had been made in gene finding and molecular genetics -- Covers schizophrenia, because of the substantial progress made during the past few years. Presenting results for a more typical and common set of psychiatric disorders where most of our information comes from basic and advanced genetic epidemiology and where we are just beginning to make advances using gene finding -- Discusses anxiety disorders, which illustrate these sets of issues. Covering disorders where major advances have been made using basic and advanced genetic epidemiology -- Details substance use disorders, where the paradigm has shifted from sociological to genetic factors and where, in contrast to the genetics of more traditional psychiatric disorders, researchers must consider the inherent conditionality of drug abuse. Investigating the role of genetics in personality disorders -- Focuses on the development of conduct and antisocial behavior and how to incorporate developmental processes into analyses of the role of genetics.
Psychiatric Genetics draws students, educators, and practitioners alike into the exciting world of psychiatric genetics with a lively discussion of its broad trends and of the strengths and limitations of its methods to provide true insight into the etiology of psychiatric and substance use disorders.