Khawaja Husnain Haider – författare

This handbook comprehensively explores various facets of stem cells in regenerative medicine, highlighting the interdisciplinary nature of the research. It covers the biology, characteristics, and applications of mesenchymal and non-mesenchymal stem cells in diverse medical contexts. The potential for treating radiation injuries, spinal cord injuries, diabetes, aging-related diseases, osteoarthritis, Alzheimer's disease, and oral surgery is thoroughly investigated, engaging bench scientists and professionals from various fields worldwide.Furthermore, it delves into the potential of neuronal stem cells for neural repair, myoblast implants for Duchenne muscular dystrophy, and immunotherapy using nongenetically modified natural killer cells. Handbook of Regenerative Medicine: Stem Cell-Based Approach also uncovers the possibilities of botanical leads combined with stem cell therapy and explores the role of stem cells in promoting healthy aging and cancer. Additionally, the book sheds light on the role of cancer stem cells, their intricate role in cancer development and chemoresistance, particulary in lungs, gliomas and gynecologic cancers, and their significance as targets in cancer treatment for better prognosis.The chapters discuss the potential of engineering mesenchymal stem cells for bone regeneration and treating intracerebral hemorrhage. Toward the end, the book elucidates cell-free scaffolding for tissue engineering, adult stem cell disease tropism, and the evolving strategies in regenerative medicine. It is intended for researchers, professionals, and academicians in regenerative medicine, stem cell biology, and medical biotechnology.

This book comprehensively reviews cell-free therapy approaches, focusing on the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (EVs) and secretomes across various reparative and regenerative medicine fields. The initial chapters primarily provide foundational insights into the application of EVs in dentistry, cardiovascular pathologies, and kidney injury. Each chapter discusses the role of mesenchymal stem cell exosomes in targeted therapies for conditions like neurodegenerative disorders, ophthalmological diseases, and diabetes complications, examining the applications of EV-based techniques in personalized medical strategies. The subsequent chapters discuss the advanced diagnostic and therapeutic applications, including using EVs as biomarkers in liquid biopsies and novel tissue engineering and cell-free scaffolding techniques for organ rejuvenation and tissue regeneration. Additionally, this book examines the challenges and progress in transitioning these therapies from laboratory research to clinical applications, covering critical aspects of formulation, Good Manufacturing Practice (GMP) production, regulatory approval, and market access. With insights into emerging technologies like 3D cell scaffolding and theragnostic applications in cancer and neurodegenerative diseases, this book emphasizes the future of a cell-free approach in regenerative medicine. This book is a useful resource for researchers and students in regenerative medicine.Key Features:Provides insights into EV-based therapies and their role in regenerative medicine across multiple medical fieldsDiscusses the potential of mesenchymal stem cell-derived exosomes in treating neurodegenerative, ophthalmological, and cardiovascular conditionsExplores cell-free scaffolding for targeted tissue and organ regenerationReviews the current regulatory, production, and clinical challenges in bringing cell-free therapies to marketExplores cutting-edge theragnostic applications of EVs in oncology and neurological disorders

Stem cell based therapy is a 21st century approach of therapeutic intervention which epitomizes a shift from conventional symptomatic treatment strategy to addressing the root cause of the disease process. This is especially a hope for the patients suffering from diseases such as Alzheimer, diabetes, myocardial infarction and other diseases which have always been considered as incurable. Moreover, stem cells provide excellent in vitro disease models for drug development. This book is a compilation of the bench experience of experts from various research labs involved in the cutting edge area of research, describing the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development.

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

During the last two decades, stem cells have progressed from merely a concept to a vibrant field of regenerative medicine which is aimed at addressing the root cause of the problem rather than conventional methods of intervention that mostly provide symptomatic relief.Stem cell therapy either alone or in combination with the other established treatment strategies is a hope for patients who suffer from the "incurable" diseases such as Alzheimer, diabetes, myocardial infarction etc. Besides aspirations in the clinical perspective, stem cells provide excellent in vitro disease models for drug development.Given the significance of the field, the proposed book will be a compilation of the bench experience of experts from various research labs involved in the cutting edge area of stem cell research.

The book highlights the therapeutic applications of various stem cells, and introduces readers to thymus stem cells and their applications in the reconstitution of thymic structure and function. It also discusses the significant role of mesenchymal stem cells (MSCs) in the treatment of autoimmune diseases and the use of MSC-derived exosomes in cell-free therapy. Moreover, it explores the application of hematopoietic stem cells in the vasculoprotection of the ischemially injured heart. Further topics include the regenerative potential of ovarian germline stem cells and the significance of endometrial stem cells in the pathogenesis of female reproductive tract diseases. Lastly, the book addresses stem cells from perinatal tissues and their immunoregulatory and differentiation potentials, and summarizes new strategies for targeting cancer stem cells to treat tumors.

The book highlights the therapeutic applications of various stem cells, and introduces readers to thymus stem cells and their applications in the reconstitution of thymic structure and function. It also discusses the significant role of mesenchymal stem cells (MSCs) in the treatment of autoimmune diseases and the use of MSC-derived exosomes in cell-free therapy. Moreover, it explores the application of hematopoietic stem cells in the vasculoprotection of the ischemially injured heart. Further topics include the regenerative potential of ovarian germline stem cells and the significance of endometrial stem cells in the pathogenesis of female reproductive tract diseases. Lastly, the book addresses stem cells from perinatal tissues and their immunoregulatory and differentiation potentials, and summarizes new strategies for targeting cancer stem cells to treat tumors.