In recent years, substantial efforts have been initiated to develop new drugs, vaccines,and other medical interventions against biological agents that could be usedin bioterrorist attacks against civilian populations. According to a new congressionallymandated report from the Institute of Medicine and National Research Council ofthe National Academies, to successfully develop these drugs, vaccines, and othermedical interventions against biowarfare agents, Congress should authorize the creationof a new agency within the Office of the Secretary of the U.S. Department ofDefense. The committee recommended that Congress should improve liability protectionsfor those who develop and manufacture these products, to stimulate willingnessto invest in new research and development for biowarfare protection. GivingFull Measure to Countermeasures also identifies other challenges—such as the needfor appropriate animal models and laboratories equipped with high-level biosafetyprotections—that will require attention if DoD efforts to develop new medical countermeasuresare to be successful.

In recent years, substantial efforts have been initiated to develop new drugs, vaccines,and other medical interventions against biological agents that could be usedin bioterrorist attacks against civilian populations. According to a new congressionallymandated report from the Institute of Medicine and National Research Council ofthe National Academies, to successfully develop these drugs, vaccines, and othermedical interventions against biowarfare agents, Congress should authorize the creationof a new agency within the Office of the Secretary of the U.S. Department ofDefense. The committee recommended that Congress should improve liability protectionsfor those who develop and manufacture these products, to stimulate willingnessto invest in new research and development for biowarfare protection. GivingFull Measure to Countermeasures also identifies other challenges—such as the needfor appropriate animal models and laboratories equipped with high-level biosafetyprotections—that will require attention if DoD efforts to develop new medical countermeasuresare to be successful.

Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market.

This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research.

In recent years, substantial efforts have been initiated to develop new drugs, vaccines,and other medical interventions against biological agents that could be usedin bioterrorist attacks against civilian populations. According to a new congressionallymandated report from the Institute of Medicine and National Research Council ofthe National Academies, to successfully develop these drugs, vaccines, and othermedical interventions against biowarfare agents, Congress should authorize the creationof a new agency within the Office of the Secretary of the U.S. Department ofDefense. The committee recommended that Congress should improve liability protectionsfor those who develop and manufacture these products, to stimulate willingnessto invest in new research and development for biowarfare protection. GivingFull Measure to Countermeasures also identifies other challenges—such as the needfor appropriate animal models and laboratories equipped with high-level biosafetyprotections—that will require attention if DoD efforts to develop new medical countermeasuresare to be successful.

In recent years, substantial efforts have been initiated to develop new drugs, vaccines,and other medical interventions against biological agents that could be usedin bioterrorist attacks against civilian populations. According to a new congressionallymandated report from the Institute of Medicine and National Research Council ofthe National Academies, to successfully develop these drugs, vaccines, and othermedical interventions against biowarfare agents, Congress should authorize the creationof a new agency within the Office of the Secretary of the U.S. Department ofDefense. The committee recommended that Congress should improve liability protectionsfor those who develop and manufacture these products, to stimulate willingnessto invest in new research and development for biowarfare protection. GivingFull Measure to Countermeasures also identifies other challenges—such as the needfor appropriate animal models and laboratories equipped with high-level biosafetyprotections—that will require attention if DoD efforts to develop new medical countermeasuresare to be successful.

Mifepristone (RU486), the first clinically available antiprogestin, has generated great interest since its discovery in the early 1980s. Today, it is recognized that mifepristone, along with other antiprogestins, has a potentially significant therapeutic role in human health and disease, with likely applicability to a variety of pregnancy-related conditions (e.g., management of labor) and to contraception, endometriosis, and cancer, among others. But because mifepristone has been studied and used most widely as a means of nonsurgical abortion, political issues have thus far limited research on the drug and prevented its introduction into the U.S. market.

This book provides an unbiased evaluation of current knowledge about both the fundamental nature of antiprogestins as well as their possible use in treating numerous diseases and conditions, and it contains recommendations for future research.