Loutfy H. Madkour – författare

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.

Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions.

Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences.

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field.

Key Features:

This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field.

Key Features:

This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies.

Key Features

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies.

Key Features

Carbon-Based Nanomaterials for Sustainable and Technological Applications covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Addressing recent advancements in technology and improvement in material synthesis, the book outlines how functionalized CNMs are used in nanobiotechnology, for active sorbent materials, and in pharmaceutical applications. Chapters cover macro-scale applications, biosensors and drug delivery, and treatment in cancer and coronavirus diseases.

Key features:

Written by a leading expert, this volume provides the reader with thorough coverage of bionanotechnology and biomedical applications of novel carbon nanomaterials.

Carbon-Based Nanomaterials for Sustainable and Technological Applications covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Addressing recent advancements in technology and improvement in material synthesis, the book outlines how functionalized CNMs are used in nanobiotechnology, for active sorbent materials, and in pharmaceutical applications. Chapters cover macro-scale applications, biosensors and drug delivery, and treatment in cancer and coronavirus diseases.

Key features:

Written by a leading expert, this volume provides the reader with thorough coverage of bionanotechnology and biomedical applications of novel carbon nanomaterials.

Carbon-Based Nanocomposite Applications and Microelectronic Technologies covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Written by a leading expert, this volume gives thorough coverage of bio-nanotechnology and biomedical applications of novel carbon nanomaterials and explores the development of microelectronics technologies and nanocomposites.

Key features:

· Covers a range of biotechnological applications, from human toxicological assessment of carbon nanotubes at biointerfaces to electrochemiluminescence (ECL), optical and glucose biosensors.

· Addresses issues of biosafety, biocompatibility and biodegradation.

· Assesses the potential for future CNMs-enzyme conjugates for potential use in cancer treatment.

·Full references can be found via the Support Material: www.routledge.com/9781032636061

This book provides a crucial study of technological and biomedical applications of CNMs and will be important reading for researchers and industry professionals working in the fields of advanced nanoelectronic materials, biotechnology and nanomedicine.

Carbon-Based Nanocomposite Applications and Microelectronic Technologies covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Written by a leading expert, this volume gives thorough coverage of bio-nanotechnology and biomedical applications of novel carbon nanomaterials and explores the development of microelectronics technologies and nanocomposites.

Key features:

· Covers a range of biotechnological applications, from human toxicological assessment of carbon nanotubes at biointerfaces to electrochemiluminescence (ECL), optical and glucose biosensors.

· Addresses issues of biosafety, biocompatibility and biodegradation.

· Assesses the potential for future CNMs-enzyme conjugates for potential use in cancer treatment.

·Full references can be found via the Support Material: www.routledge.com/9781032636061

This book provides a crucial study of technological and biomedical applications of CNMs and will be important reading for researchers and industry professionals working in the fields of advanced nanoelectronic materials, biotechnology and nanomedicine.

This book presents synthesis techniques for the preparation of low-dimensional nanomaterials including 0D (quantum dots), 1D (nanowires, nanotubes) and 2D (thin films, few layers), as well as their potential applications in nanoelectronic systems. It focuses on the size effects involved in the transition from bulk materials to nanomaterials; the electronic properties of nanoscale devices; and different classes of nanomaterials from microelectronics to nanoelectronics, to molecular electronics. Furthermore, it demonstrates the structural stability, physical, chemical, magnetic, optical, electrical, thermal, electronic and mechanical properties of the nanomaterials. Subsequent chapters address their characterization, fabrication techniques from lab-scale to mass production, and functionality. 

In turn, the book considers the environmental impact of nanotechnology and novel applications in the mechanical industries, energy harvesting, clean energy, manufacturing materials,electronics, transistors, health and medical therapy. In closing, it addresses the combination of biological systems with nanoelectronics and highlights examples of nanoelectronic–cell interfaces and other advanced medical applications. 

The book answers the following questions:

• What is different at the nanoscale?

• What is new about nanoscience?

• What are the fundamental issues in nanomaterials?

• Where are nanomaterials found?

• What is the importance of NMs in our lives?

• Why so much interest in nanomaterials?

• What is graphene?

• Are pure low-dimensional systems interesting and worth pursuing?

• What are sensors?

• How can Artificial Intelligence (AI) and nanotechnology work together?

• What are the latest applications of NMs?