M. Allgower – författare

Tumor Specific Transplantation Antigen reviews the theories, methods, and experimental findings in the field of immunobiology of tumors with particular focus on the tumor antigen responsible for transplantation resistance. The monograph presents discussions on the methods of induction of antitumor immunity; methods of detection of antitumor immunity; virus-induced tumors; the characteristics of TSTA; tumor growth and development of immunity; and the theoretical and practical possibilities of the presence of transplantation immunity against tumors in man. Oncologists, cell biologists, immunobiologists, and medical researchers will find the book invaluable.

The Role of Chromosomes in Cancer Biology provides a description of the molecular organization and function of chromosomes and the consequences of chromosomal aberrations in human development. The book presents accounts on the structure and function of the chromosome; the cellular features of primary tumors and ascetic fluid; the cytological actions of radiation and drugs and their relevance to therapy. Developmental disorders caused by chromosomal anomalies; chromosome aneuploidy in human malignancies; and viral oncogenesis are discussed as well. The book will prove to be very insightful to those involved in cancer research, oncologists, cytologists, and molecular biologists.

Recent Results in Cancer Research: Bone Mineral Metabolism in Cancer presents the clinical approach to bone tissue metabolism, which depends on studying the plasma state, renal handling, kinetics, and balance of calcium and inorganic phosphate. This book discusses the problems of bone mineral metabolism in patients with cancer. Organized into five chapters, this book begins with an overview of the two major phases of bone mineral, namely, amorphous calcium phosphate and crystalline bone apatite. This text then examines the plasma state and renal handling of calcium and inorganic phosphate under controlled metabolic conditions. Other chapters consider the variability of each parameter in the majority of patients without bone secondaries. This book discusses as well the normal remodeling of bone in fertile-age women. The final chapter deals with the plasma state, renal handling, and kinetics of calcium and phosphate in plasmacytoma patients. This book is a valuable resource for oncologists.

Recent Results in Cancer Research: Hormones and Human Breast Cancer provides information pertinent to the fundamental aspects of breast cancer and hormones. This book discusses the endocrine factors involved in breast cancer. Organized into two parts encompassing 11 chapters, this book begins with an overview of the process of castration as an effective therapeutic measure in many pre-menopausal patients with advanced breast cancer. This text then discusses the response rate following ablation wherein only 60 percent of patients subjected to hormone therapy as a first treatment for recurrence will survive to ablation. Other chapters consider the microscopical features of a tumor. This book discusses as well the prescription of corticosteroids as treatment, which originates from the mechanism of response that followed adrenalectomy or hypophysectomy. The final chapter deals with the use of radio-immunoassay methods in treating breast cancer. This book is a valuable resource for biochemists, scientists, and physicians.

International surgical meetings with thousands of participants speaking a dozen different languages tend to be frustrating for the individual who comes with the hope of learning about progress in his fields, but who additionally would like to be able to ex­ change ideas on controversial topics and to meet competent people with whom to discuss specific problems. In the "one-way" ses­ sions in which long papers are presented, details or specific points may be missed. Differing views often are not adequately discussed, because the meeting and its participants are pressed for time. The 44 breakfast and luncheon sessions, covering different topics of interest to the practicing surgeon, were mainly planned to overcome these classical "congress handicaps" and also to do away with the anonymous atmosphere of such a large congress. Slides and formal papers were banished from these sessions. The outcome of these very lively and pleasant discussions taking place around small well-dressed tables was unexpected by most participants. A chairman and several panel members shared their repast, caloric and intellectual, with some 10-30 congress par­ ticipants. The result was in each instance a lively, informative intimate discussion, very different from the anonymous atmo­ sphere of a large meeting. In the hope of preserving these ex­ changes, the chairmen were requested immediately the session finished to "distill the essence" of the 90-minute exchange into a summary captured on tape.

More than a century ago, Cripps successfully employed the direct and complete division of the anal sphincters as a means of approaching the lower rectum and anal canal, and reported on a series of 36 patients who had been treated in that fashion. Cripps was pleasantly surprised to find good fecal continence in over two-thirds of the patients during later follow-ups, despite the fact that the divided sphincters had not been repaired. The transsphincteric procedure was largely forgotten in subsequent years, however, and only the parasacral proctotomy of Kraske, which spared the anal sphincters, can be said to have gained an established place in the" surgical armamentarium. " It remained for York Mason to redirect the attention of the surgical community to the great potential of the trans­ sphincteric approach and the excellent continence that can be achieved through adequate repair of the divided sphincters. Having recognized the outstanding practical value of this procedure, we felt it necessary to define more precisely the anatomical prerequisites that would ensure minimum operative bleeding, and to bring the procedure more in line with current knowledge of normal continence and defecation. Dr. A. Huber, in consultation with the director of the Institute for Clinical Anatomy of our surgical department, Prof. A. von Hochstetter, did many months of dissection work on fresh anatomic preparations in an effort to explore and refine the various aspects of the trans sphincteric ap­ proach.

The AOjASIF* dynamic hip screw (DRS) has been designed primarily to stabilize trochanteric fractures of the hip. Selected fractures of the femoral neck and some subtrochanteric fractures are further indications for the DRS [40, 46]. The dynam­ ic condylar screw (DCS) has been developed for fractures of the distal femur and is now being tested clinically. The DRS and DCS are carefully coordinated with the preexisting ASIF standard sets of equipment for internal fixation of fractures. The concept of a sliding screw for trochanteric fractures is not new. The first author describing such an implant was Schumpelick [44]; he gives credit to Pohl [22], who was primarily a manufacturer working for Gerhardt Kiinscher. Re described the possibility of impaction at the fracture site with a sliding device. In the United States Clawson [7, 8] introduced the hip screw and found it to be extremely beneficial in trochanteric fractures. At approximately the same time, Massie [31, 32] and Pugh [39] designed the sliding-type flange nails, which offer similar intramedullary splinting with the possibility of fracture impaction. The following chapters describe the concept and design features of the DRS, as well as the details of the surgical technique. The application of the DRS for different types of fractures is illustrated with clinical examples. The results of 268 cases of trochanteric fractures treated with the DRS are presented and compared with results using the angled blade plate and Ender''s nails. Finally, some laboratory tests are described.

Seit der 1. Auflage gab es so wesentliche Neuerungen, vor allem in der Therapie, daß es notwendig war, das Werk fast völlig neu zu konzipieren und zu schreiben. Wie außerordentlich das Wissen in der Gastroenterologie in den letzten Jahren angewachsen ist, zeigt quantitativ der Umfang des Buches. Eigentlich gibt es jetzt keine 2. Auflage, sondern eine annähernd komplette Neukonzeption. Der Begriff "Chirurgische Gastroenterologie" beinhaltet sowohl die gastroenterologische Chirurgie als auch das notwendige Wissen, um eine adäquate Diagnostik und Entscheidungsfindung bei gastroenterologischen Erkrankungen herbeizuführen. Das Buch vermittelt nicht nur das moderne Wissen zur Pathophysiologie und Pathogenese gastroenterologischer Erkrankungen, sondern auch die zielstrebige Diagnostik und Indikationsstellung zur gastroenterologischen Chirurgie. Der interessierte Leser kann alle notwendigen Informationen finden, die zum Verständnis gastroenterologischer Erkrankungen und chirurgischer Entscheidungen notwendig sind - beschrieben von den jeweiligen Kapazitäten. Damit ist das Buch nicht nur für Chirurgen wertvoll, sondern auch für Gastroenterologen und Internisten, die sich über die chirurgischen Möglichkeiten bei Erkrankungen des Verdauungstrakts informieren möchten. Auch Vertreter anderer an der Behandlung gastroenterologischer Erkrankungen beteiligten Disziplinen wie Röntgenologie, Strahlentherapie, Nuklearmedizin, Onkologie etc. finden wesentliche Informationen.

It is to the great and lasting credit of LORENZ BOHLER and his school that they have in the last decade developed and demonstrated so thoroughly the techniques for the conservative management of fractures. Nevertheless there have always been many, including some from BOHLER''S school, who have found considerable place for surgical management, and with the significant progress in general surgery seen in postwar years, a new stimulus has been given to this part of traumatic surgery, especially since bone injuries have become more complex and frequent. The concept of internal fixation is not new. The serious criticisms that have been levelled at it retain today their basic significance. Progress in the fields of asepsis, corrosion-free metal implants, operative experience and postoperative care has diminished the dangers but has not relieved the surgeon of responsibility. The Association for the Study of the Problems of Internal Fixation (AO) has devoted itself over a number of years to the basic principles and best methods of open treatment of fractures by means of extended clinical and scientific studies in order to determine in each individual case the most promising line of treatment. At the same time a well designed and tested instrument set has been developed with precise instructions for the appropriate techniques. As a result, the new observations about primary bone healing which have emerged from the practice of rigid internal fixation are as interesting as the uses to which they can be put in allowing early mobilization.

The German edition of our book entitled "Operative Frakturen­ behandlung" by M. E. MÜLLER, M. ALLGÖWER and H. WILLENEGGER (Springer, Berlin . Göttingen . Heidelberg, 1963) has been out of print now for more than three years. We are planning a new edition which will deal with the collective experience of 14,000 new cases, all treated by internal fixation, and will include the newest developments in the field of internal fixa­ tion. However, it will be some time before this new edition can be published. Increasing demands for a description of the AO technique of internal fixation has stimulated us to publish this manual. In it we shall describe in a comprehensive but somewhat apodictic mann er the principles and techniques of the AO methods of fracture treatment and reconstructive surgery, which in our hands, have stood the test of time. The book is written in a somewhat abbreviated style. It cor­ responds in subject matter to the teaching given at the AO courses in Davos, but deals with each subject more thoroughly. We have dispensed with pictures of the instruments, as these may be found in the Synthes Catalogue *. This manual should be regarded as the product of collective experiencc, containing new thoughts and new discoveries from basic research. In considering the risks of mistakes and dangers, we can only reiterate what we have already stated in "Technique of Internal Fixation of Fractures": "Open treatment of fractures is a valuable but difficult method which involves much responsibility.