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This volume contains the proceedings of the Symposium on GHRH, GH, and IGF-1: Basic and Clinical Advances, held December 9 - 12, 1993 in San Diego, California. Written and edited by eminent international experts, the papers herein cover: an overview of the physiology of GHRH-Somatostatin-GH-IGF-1 axis; the effects of recombinant human GH and/or IGF-1 in catabolic illness; contemporary issues in growth and development; the effects of rhGH and IGF-1 on intermediary and bone metabolism; and the use of GHRH, rhGH, and rhIGF-1 in aging.