Maria Castro – författare

The dramatic expansion in genomic information has motivated the development of new approaches to characterize gene expression and function. A critical issue for both basic and clinical endocrinologists is the physiological role of genes involved in regulating endocrine functions. Transgenic technologies allow the translation of genotypic information into specific phenotypes by using gene overexpression or loss of specific gene functions. This book has been designed to reflect a multidisciplinary approach to transgenics in endocrinology, encompassing contributions from internationally recognized experts in many aspects of endocrine physiology. These range from the basic technologies underpinning the generation of transgenic rats and mice, to knock-out mice and also transgenics using viral vectors for gene delivery. The authors have aimed to exemplify the use of transgenic technologies and models for the study of a wide range of endocrine topics, including, reproductive functions, the stress axis, control of lactation, water and electrolyte balance, appetite control and pituitary tumour therapy.

Charting the legacy of Matisse's pivotal Fauvist painting across 120 yearsPublished with San Francisco Museum of Modern Art.Henri Matisse's Femme au chapeau (Woman with a Hat) was at the center of a rupture in the history of modern art. Its debut at the 1905 Salon d'Automne in Paris ignited passionate controversy, leading to its establishment as a key image of Fauvism, the first French avant-garde movement of the 20th century. The painting also marked a pivotal moment in Matisse's career, as it captured the attention of American collectors Leo and Gertrude Stein, who acquired the work on the last day of the exhibition. Woman with a Hat later made its way to the collection of their brother and sister-in-law, Michael and Sarah Stein, who brought it across the Atlantic to the Bay Area in 1935. Matisse's painting was shown in the United States for the first time early the next year, in an exhibition at the San Francisco Museum of Art (now SFMoMA). Since entering the museum's collection in 1991, it has continued to influence contemporary artists, who derive inspiration from its bold approach to color and form.This publication examines in unprecedented depth how this portrait of Matisse's wife, Amélie, made its mark on art history. Positioning Matisse in dialogue with his predecessors, contemporaries, collaborators and successors, this volume probes the painting's historical context and impact over more than 120 years.Henri Matisse (1869–1954) was a pillar of the Parisian avant-garde. His innovations were the use of vibrant, arbitrary colors; bold brushstrokes; and a flattening of spatial depth. He often applied his thoroughly modern style to traditional subjects such as still lifes, landscapes and portraits that express a sense of timeless joy and stillness.