Mario Grassi – författare
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3 produkter
3 produkter
Physicochemical Approaches to the Characterization of Pharmaceutical Systems
Inbunden, Engelska, 2019
1 766 kr
Kommande
Understanding Drug Release and Absorption Mechanisms
A Physical and Mathematical Approach
Inbunden, Engelska, 2006
2 053 kr
Tillfälligt slut
Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release.Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes. Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.
608 kr
Kommande
This open access book examines how Piedmont, in early modern Italy, developed silk production into a distinctive system of technological and social innovation. It explores the ways in which this fragile yet economically significant material shaped regional strategies of adaptation and growth, linking local expertise to the expanding networks of global trade. Across ten chapters, the author traces the evolution of a complex production ecosystem, from small workshops to royal manufactories, and considers how technology, policy, and labour interacted to sustain the silk economy. Particular attention is given to the contributions of women, migrants, and apprentices, whose work underpinned both the aesthetics of fashion and the practical mechanisms of manufacture. As political and economic transformations unfolded across eighteenth-century Europe, silk became a lens through which to examine tensions between tradition and change, and between vulnerability and resilience. By situating Piedmont within broader European processes, the book demonstrates that innovation emerged not solely from institutional or technological breakthroughs, but from the craft of making, the capacity to adapt, and the steady labour of human hands.