Mark Wigglesworth – författare

* A Financial Times Book of the Year *'What does a conductor do? It may be a favourite joke among the musicians in an orchestra, but Wigglesworth wants to find a more thoughtful answer. Avoiding jargon, he analyses what he has discovered during 30 years in the job.' Financial Times, Books of the Year A conductor is one of classical music's most recognisable but misunderstood figures, attracting so many questions:'Surely orchestras can play perfectly well without you? ''Do you really make any difference to the performance?''Are the musicians even watching you?'The Silent Musician is not a manual for conductors, nor a history of conducting. It is for all who wonder what conductors actually do, and why they matter.

A conductor is one of classical music's most recognizable figures. Many people who have never actually been to an orchestral concert have an image of what one looks like. But rarely does such a well-known profession attract so many questions: 'Surely orchestras can play perfectly well without you? Do you really make any difference to the performance?'This book is not intended to be an instruction manual for conductors, nor is it a history of conducting. It is for all who wonder what conductors actually do. Exploring the relationships with the musicians and music they conduct, and the public and personal responsibilities they face, leading conductor Mark Wigglesworth writes with engaging honesty about the role for any music lover curious to know whether or not the profession really matters.

High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In High Throughput Screening: Methods, Techniques and Applications, leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. High Throughput Screening: Methods, Techniques and Applications provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, High Throughput Screening: Methods, Techniques and Applications provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both today’s and the hit identification laboratories of the future.

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire fi eld of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.