Massimo Filippi – författare

Functional Connectivity of the Human Brain: From Mechanisms to Clinical Applications is a comprehensive review of mechanisms and analysis of methods of functional connectivity to map brain organization in healthy individuals and sick patients. Providing full coverage of the discipline for a wide audience of different research and clinical specialists, this volume begins with descriptions of mechanisms of functional connectivity and methodological approaches to quantify it, followed by a focus on how functional connectivity has been used to describe brain function in healthy people and to characterize network disruption in diseased conditions. This practical balance in book structure is suitable for readers with a technical or clinical orientation, providing background that is easy to approach for clinicians or scientists. Chapters examine fMRI and electrophysiological techniques, brain maturation, aging, and cognitive neurosciences, as well as functional connectivity in neuroinflammatory, neurodegenerative, and neuropsychiatric conditions. Future perspectives look forward to functional connectivity in multimodal analysis, artificial intelligence, and more. This book will be of use to a wide audience working on functional connectivity experiments, as well as any courses on the topic.

This third edition volume expands on the previous edition with updates on the latest methodological aspects of fMRI and achievements made through the applications to the study of central nervous system functioning in the clinical field. The chapters in the book are organized in four parts: Part One talks about the basic knowledge for the understanding of the technical aspects of fMRI. Part Two describes the main findings obtained from the application of fMRI to study brain system function of healthy individuals. Part Three explores clinical findings obtained from the use of fMRI to assess the role of brain plasticity in major neurological and psychiatric conditions. Part Four presents novel approaches for the integration of fMRI data with measures of damage assessed using structural MR techniques and the use of fMRI to image spinal cord function. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and comprehensive, fMRI Techniques and Protocols, Third Edition provides clinicians and researchers with a “user-friendly” summary of the field, and helps them plan and carry out successful studies.

The second edition of this volume provides up-to-date methods on the main methodological aspects of functional MRI (fMRI), applying fMRI to the study of central nervous system, and future evolutions of fMRI techniques. fMRI: Method and Protocols, Second Edition guides the reader through chapters on basic knowledge for the understanding of the technical aspects of fMRI, overview of the main results derived from the application of fMRI to the study of healthy individuals, application of fMRI to assess the role of brain plasticity in the major neurological and psychiatric conditions, and novel approaches for the integration of fMRI data.

Concise and easy-to-use, fMRI: Method and Protocols, Second Edition aims to be useful to clinicians and researchers with a user-friendly summary of the field and necessary background ensuring further successful studies.

As fMRI technology has provided invaluable insights into the mechanisms through which the human brain works in healthy individuals and in patients with different neurological and psychiatric conditions, the study of brain function and even the monitoring of the effects of treatment have become more effective and efficient. In fMRI Techniques and Protocols, an international assemblage of renowned scientists and physicians provide the background needed to plan and design new studies in order to advance our knowledge of the physiology of the normal human brain and its change following tissue injury. With sections focusing on basic principles of fMRI, its application to measure brain function, clinical applications, and glimpses into the future of fMRI development, the volume condenses this ample, varied field into one user-friendly compendium of information and techniques.

Comprehensive and cutting-edge, fMRI Techniques and Protocols is an ideal guide for all those who wish to continue expanding this dynamic and ever-growing field of research.

This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS).

WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions.

This book helps physicians select from among the currently available imaging tools, promoting the correct and cost-saving diagnosis and management of common dementias. Magnetic resonance (MR) and nuclear medicine techniques are routinely used to facilitate diagnosis, select therapies, provide information regarding the prognosis, and monitor therapy response in patients with cognitive impairment and dementia. Furthermore, the advent of quantitative MR techniques, such as diffusion-weighted imaging, perfusion imaging, etc. have opened up new opportunities to diagnose neurological diseases based on objective findings, and offer unique new insights into the main neurodegenerative diseases of the human brain. However, the practical value of various neuroimaging techniques in clinical practice has yet to be clearly defined, and their potential for future development is not yet fully appreciated.

To help remedy the situation, this book offers practical and useful algorithms and rulesthat can be directly applied in the clinical setting. It provides concise content, together with a wealth of clinical case material.

In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.