Maria A. Rocca - Böcker

For more than 70 years, McAlpine's Multiple Sclerosis has been the gold standard textbook on the science and clinical practice of MS. The 5th Edition of this classic, landmark text reflects recent advances in this complex field, bringing you up to date with current information on genetics, epidemiology, clinical neurology, pathogenesis, and management of this common neurological disease. Easy to read and abundantly illustrated, this updated reference is a must-have resource for neurologists, neuropathologists, neurophysiologists, researchers, PM&R specialists, and others who can benefit from authoritative, comprehensive coverage of both scientific and clinical aspects of MS.

Functional Connectivity of the Human Brain: From Mechanisms to Clinical Applications is a comprehensive review of mechanisms and analysis of methods of functional connectivity to map brain organization in healthy individuals and sick patients. Providing full coverage of the discipline for a wide audience of different research and clinical specialists, this volume begins with descriptions of mechanisms of functional connectivity and methodological approaches to quantify it, followed by a focus on how functional connectivity has been used to describe brain function in healthy people and to characterize network disruption in diseased conditions. This practical balance in book structure is suitable for readers with a technical or clinical orientation, providing background that is easy to approach for clinicians or scientists. Chapters examine fMRI and electrophysiological techniques, brain maturation, aging, and cognitive neurosciences, as well as functional connectivity in neuroinflammatory, neurodegenerative, and neuropsychiatric conditions. Future perspectives look forward to functional connectivity in multimodal analysis, artificial intelligence, and more. This book will be of use to a wide audience working on functional connectivity experiments, as well as any courses on the topic.

Covers the main mechanisms of functional connectivityProvides an overview of the main methodological aspects to map brain organizationDescribes state-of-the-art achievements obtained with functional connectivity to study network functioning in healthy individuals and sick patientsDiscusses future developments in the field

This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging.