McAlpine's Multiple Sclerosis

Alasdair Coles, Ph.D. is a Professor of Neuroimmunology in the Division of Clinical Neurosciences at the University of Cambridge. Has been doing MS research in Cambridge since 1994. He is also a consultant neurologist. With Alastair Compston, he was very involved in the development of alemtuzumab as a treatment of MS. He is employed as a senior lecturer by Cambridge University and has a small research team managing clinical trials and doing human immunological laboratory work. He does clinical work for two days a week as a consultant neurologist at Addenbrooke's and Peterborough Hospitals, is one of the medical advisers to the Multiple Sclerosis Society of the UK, and advises several pharmaceutical companies. V. Wee Yong, PhD, is a professor of translational neuroscience at the Hotchkiss Brain Institute and the Departments of Clinical Neurosciences and Oncology at The University of Calgary. He co-directs the Multiple Sclerosis (MS) Program of the Hotchkiss Brain Institute, and he holds the Canada Research Chair in Neuroimmunology. Alastair Compston, PhD is Emeritus Professor of Neurology in the Division of Clinical Neurosciences at the University of Cambridge. Compston's research focuses on the clinical science of human demyelinating disease including the discovery of genetic risk factors for multiple sclerosis and the introduction of alemtuzumab. Compston was formerly Professor of Neurology at the University of Wales, president of the European Neurological Society and the Association of British Neurologists, and editor of the journal Brain. Compston's work has been recognised by prizes including the Charcot Award; the K-J Zülch Prize; the World Federation of Neurology Medal; the John Dystel Prize; the Richard and Mary Cave Award of the Multiple Sclerosis Society of Great Britain; the Hughlings Jackson Medal; the Galen Medal; and the Association of British Neurologists Medal. Compston was elected a Fellow of the Royal Society (FRS) in 2016and appointed Commander of the Order of the British Empire (CBE) in the 2016 New Year Honours. Catherine Lubetzki, MD, PhD, is a professor of neurology at the Pierre and Marie Curie University as well as head of the Department of Neurological Diseases at the Salpêtrière Hospital. She coordinates the Clinical Research Centre for Multiple Sclerosis at Salpêtrière. Professor Rocca is Head of the "Neuroimaging of CNS White Matter Unit”, Division of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy and Associate Professor of Neurology at Vita-Salute San Raffaele University. Her activity is mainly focused on the application of structural and functional MR based techniques to improve the understanding of CNS function and dysfunction in healthy individuals and diseased people, particularly patients with multiple sclerosis (MS) and other white matter disorders. She is currently conducting and coordinating several national and international projects in adult and pediatric populations. She is also extensively applying advanced methods of analysis in an attempt to improve the understanding of the role of brain functional and structural plasticity in the different phases of MS, and the influence of pharmacological and rehabilitative interventions on brain reorganization. Prof. Rocca is member of various national and international Scientific Societies and, in some of them, she covered or is covering institutional roles. She has been chair of the MAGNIMS network since 2018, and is author or co-author of 53 book chapters and more than 500 papers published on peer-reviewed journals. Professor Steve Vucic is affiliated with the Brain and Nerve Research Center, The University of Sydney and the Concord General and Repatriation Hospital. Professor Vucic is a clinical academic and internationally recognized researcher in the field of neuroscience with an emphasis on understanding amyotrophic lateral sclerosis (ALS) pathogenesis. Brian G. Weinshenker, MD, is a professor of neurology at the University of Virginia. He arrived at UVA Health's neurology department in 2022 after 35 years of experience practicing, including 30 years as a neurologist at the Mayo Clinic in Rochester, MN.

• 1. The Concept of Multiple Sclerosis2. The Pathogenesis and Etiology of Multiple Sclerosis3. The Person With Multiple Sclerosis: Treatment and Society4. Telling the Story: Literature and McAlpine’s Multiple Sclerosis5. Distribution of Multiple Sclerosis6. Natural History of Multiple Sclerosis7. Diagnosis and Classification of Multiple Sclerosis8. Symptoms and Signs9. Imaging Structure10. Measuring Function11. Blood and CSF Markers of Damage and Disease Activity12. Diagnosis and Differential Diagnosis13. Genetic Analysis of Multiple Sclerosis14. Immunology of Multiple Sclerosis15. Neurobiology of Multiple Sclerosis16. The Pathogenesis of Multiple Sclerosis: A Pandect17. Care of the Person With Multiple Sclerosis18. The Acute Attack of Multiple Sclerosis and Its Treatment19. The Treatment of Symptoms in Multiple Sclerosis20. Disease-Modifying Immunotherapies21. Reparative Therapies22. Monitoring Treatment