Michael Schrader – författare

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The only book to cover and compare Oracle's online analytic processing products

With the acquisition of Hyperion Systems in 2007, Oracle finds itself owning the two most capable OLAP products on the market--Essbase and the OLAP Option to the Oracle Database. Written by the most knowledgeable experts on both Essbase and Oracle OLAP, this Oracle Press guide explains how these products are similar and how they differ. Oracle Essbase & Oracle OLAP will help you architect the Oracle OLAP product that is most appropriate for your application, and build, tune, and maintain OLAP solutions.

The only book to cover and compare Oracle''s online analytic processing products

With the acquisition of Hyperion Systems in 2007, Oracle finds itself owning the two most capable OLAP products on the market--Essbase and the OLAP Option to the Oracle Database. Written by the most knowledgeable experts on both Essbase and Oracle OLAP, this Oracle Press guide explains how these products are similar and how they differ. Oracle Essbase & Oracle OLAP will help you architect the Oracle OLAP product that is most appropriate for your application, and build, tune, and maintain OLAP solutions.

This volume provides easily accessible and comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Chapters detail valuable instructions, guidelines and protocols for molecular cell biologists, biochemists and biomedical researchers with an interest in peroxisome biology. Chapters in Peroxisomes: Methods and Protocols illustrate the isolation of peroxisomes, investigation of properties of membrane proteins, protocols to investigate and manipulate peroxisomes in cellular systems, detection of peroxisomes, including immunofluorescence, cytochemistry, cryo-immuno electron microscopy, and live cell imaging approaches.

Authoritative and practical, Peroxisomes: Methods and Protocols aims to be useful for those already working on peroxisomes as well as for those who would like to start working on this fascinating organelle.

This volume describes protocols for basic state-of-the-art approaches in the field of peptidomics. Most of these approaches are independent of the instruments used for analysis and can easily be adapted for equipment that is available in a typical proteomics facility. Chapters detail many of the basic techniques used to detect and identify peptides, methods for the relative quantitation of peptides between samples using isotopic labels or label-free approaches, and biological species as well as sample types. Written in the highly successful format of the Methods in Molecular Biology series, each chapter includes an introduction to the topic, a list of the necessary materials and reagents, reproducible step-by-step laboratory protocols, and tips on troubleshooting common problems and avoiding pitfalls.

Authoritative and practical, Peptidomics: Methods and Strategies provides useful guidance for studies in the rapidly growing field of peptidomics. 

Dieses Lehrbuch ist als kompakte Einführung in die Physikalische Chemie für Biowissenschaftler und -ingenieure in Bachelor-Studiengängen konzipiert worden. Es vermittelt alle relevanten Grundlagen dazu, inklusive Protokollerstellung und Datenauswertung in Praktika. Diese zweite Auflage wurde wesentlich erweitert. So soll es auch für Studierende in der Chemie, im Chemieingenieurwesen, in pharmazeutischer Technologie oder verwandten Gebieten eine Basis sein. Die wichtigsten Grundlagen, insbesondere von Thermodynamik und Kinetik, werden mit der dazu nötigen Mathematik umfassend erläutert. Zum Üben und tieferen Verständnis dienen zahlreiche Beispiele und Übungsaufgaben (mit Ergebnissen), die die Vielfalt der Anwendungsmöglichkeiten und -gebiete illustrieren. Darüber hinaus werden Simulationen in Tabellenkalkulations-Software erstellt und als Zusatzmaterial zur Verfügung gestellt. So kann ein solides Verständnis von Physikalischer Chemie entwickelt werden, das erfahrungsgemäß zu vielen praktischen Lösungen führt.

This new edited volume in the Springer Subcellular Biochemistry Series presents a comprehensive, state-of-the-art overview of the proteomics of peroxisomes derived from mammalian, Drosophila, fungal, and plant origin, and contains contributions from leading experts in the field. 

The development of sensitive proteomics and mass spectrometry technologies, combined with bioinformatics approaches now allow the identification of low-abundance and transient peroxisomal proteins and permits to identify the complete proteome of peroxisomes, with the consequent increase of our knowledge of the metabolic and regulatory networks of these important cellular organelles. The book lines-up with these developments and is organized in four sections including: (i) mass spectrometry-based organelle proteomics; (ii) prediction of peroxisomal proteomes; (iii) analysis of peroxisome proteome interaction networks; and (iv) peroxisomes in relation to other subcellular compartments.

The editor Luis A. del Río is Professor ad honorem of the Spanish National Research Council (CSIC) in the Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Biochemistry and Cell & Molecular Biology of Plants, at the Estación Experimental del Zaidín, Granada, Spain. Del Río’s research group focuses on the metabolism of reactive oxygen species (ROS), reactive nitrogen species (RNS) and antioxidants in plant peroxisomes, and the ROS- and RNS-dependent role of peroxisomes in plant cell signalling. 

The editor Michael Schrader is Professor of Cell Biology & Cytopathology in the Department of Biosciences at the University of Exeter, UK. Using mammalian peroxisomes as model organelles, Prof. Schrader and his team aim to unravel the molecular machinery and signalling pathways that mediate and regulate the formation, dynamics and abundance of these medically relevant cellular compartments.