Michael Shapiro – författare
1 200 kr
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2 395 kr
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723 kr
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2 255 kr
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2 477 kr
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2 867 kr
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Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include:
an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generationWith contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.
429 kr
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281 kr
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206 kr
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427 kr
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909 kr
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942 kr
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3 194 kr
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2 189 kr
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891 kr
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This groundbreaking and innovative text addresses the deep ontological and epistemological commitments that underpin conventional positivist methods and then demonstrates how "method" can be understood in much broader and more interesting ways.
Drawing on a broad range of philosophical and methodological theory as well as a wide variety of artistic sources from fine art to cinema and from literature to the blues, leading contemporary thinker Michael Shapiro shows the reader how a more open understanding of the concept of method is rewarding and enlightening. His notion of ‘writing-as-method’ is enacted throughout the text and offers a stimulating alternative for students to positivist social science methods.
This is essential reading for all students and faculty with an interest in post-positivist methods.
891 kr
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This groundbreaking and innovative text addresses the deep ontological and epistemological commitments that underpin conventional positivist methods and then demonstrates how "method" can be understood in much broader and more interesting ways.
Drawing on a broad range of philosophical and methodological theory as well as a wide variety of artistic sources from fine art to cinema and from literature to the blues, leading contemporary thinker Michael Shapiro shows the reader how a more open understanding of the concept of method is rewarding and enlightening. His notion of ‘writing-as-method’ is enacted throughout the text and offers a stimulating alternative for students to positivist social science methods.
This is essential reading for all students and faculty with an interest in post-positivist methods.
992 kr
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This edited volume seeks to propose and examine different, though related, critical responses to modern cultures of war among other cultural practices of statecraft. Taken together, these essays present a space of creative engagement with the political and draw on a broad range of cultural contexts and genres of expressions to provoke the thinking that exceeds the conventional stories and practices of international relations.
In contrast to a macropolitical focus on state policy and inter-state hostilities, the contributors to this volume treat the micropolitics of violence and dissensus that occur below [besides and against] the level and gaze that comprehends official map-making, policy-making and implementation practices. At a minimum, the counter-narratives presented in these essays disturb the functions, identities, and positions assigned by the nation-state, thereby multiplying relations between bodies, the worlds where they live, and the ways in which they are ‘equipped’ for fitting in them.
Contributions deploy feature films, literature, photography, architecture to think the political in ways that offer glimpses of realities that are fugitive within existing perspectives. Bringing together a wide range of theorists from a host of geographical, cultural and theoretical contexts, this work explores the different ways in which an aesthetic treatment of world politics can contribute to an ethics of encounter predicated on minimal violence in encounters with people with different practices of identity.
This work provides a significant contribution to the field of international theory, encouraging us to rethink politics and ethics in the world today.
992 kr
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This edited volume seeks to propose and examine different, though related, critical responses to modern cultures of war among other cultural practices of statecraft. Taken together, these essays present a space of creative engagement with the political and draw on a broad range of cultural contexts and genres of expressions to provoke the thinking that exceeds the conventional stories and practices of international relations.
In contrast to a macropolitical focus on state policy and inter-state hostilities, the contributors to this volume treat the micropolitics of violence and dissensus that occur below [besides and against] the level and gaze that comprehends official map-making, policy-making and implementation practices. At a minimum, the counter-narratives presented in these essays disturb the functions, identities, and positions assigned by the nation-state, thereby multiplying relations between bodies, the worlds where they live, and the ways in which they are ‘equipped’ for fitting in them.
Contributions deploy feature films, literature, photography, architecture to think the political in ways that offer glimpses of realities that are fugitive within existing perspectives. Bringing together a wide range of theorists from a host of geographical, cultural and theoretical contexts, this work explores the different ways in which an aesthetic treatment of world politics can contribute to an ethics of encounter predicated on minimal violence in encounters with people with different practices of identity.
This work provides a significant contribution to the field of international theory, encouraging us to rethink politics and ethics in the world today.
858 kr
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The Time of the City is a trans-disciplinary work with a focus on genre-city relationships as they articulate the micropolitics of urban life in diverse cities. Shifting the territorial emphasis of political studies from the mosaic of states to the global network of cities, the book draws on urban theory rather than traditional forms of official city politics. Deriving their methodological approaches from aspects of urban theory and philosophies of aesthetics, the chapters deploy concepts from philosophy, political theory, literary studies, cinema studies, poetics and aesthetic theory on diverse cities, among which are Berlin, Hong Kong, London, Los Angeles, New York, Philadelphia and Washington, DC.
Investigating a wide variety of urban formations, and developing a geophilosophy appropriate to urban space, this multi genre approach to urban life provides stunning insights into the micropolitics of ethnicity, identity, security, subjectivity and sovereignty.
858 kr
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The Time of the City is a trans-disciplinary work with a focus on genre-city relationships as they articulate the micropolitics of urban life in diverse cities. Shifting the territorial emphasis of political studies from the mosaic of states to the global network of cities, the book draws on urban theory rather than traditional forms of official city politics. Deriving their methodological approaches from aspects of urban theory and philosophies of aesthetics, the chapters deploy concepts from philosophy, political theory, literary studies, cinema studies, poetics and aesthetic theory on diverse cities, among which are Berlin, Hong Kong, London, Los Angeles, New York, Philadelphia and Washington, DC.
Investigating a wide variety of urban formations, and developing a geophilosophy appropriate to urban space, this multi genre approach to urban life provides stunning insights into the micropolitics of ethnicity, identity, security, subjectivity and sovereignty.
2 255 kr
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597 kr
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836 kr
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358 kr
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706 kr
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This work is a critical intervention into the archive of female identity; it reflects on the ways in which the Central and Eastern European female ideal was constructed, represented, and embodied in communist societies and on its transformation resulting from the political, economic, and social changes specific to the post-communist social and political transitions.
During the communist period, the female ideal was constituted as a heroic mother and worker, both a revolutionary and a state bureaucrat, which were regarded as key elements in the processes of industrial development and production. She was portrayed as physically strong and with rugged rather than with feminized attributes. After the post-communist regime collapsed, the female ideal’s traits changed and instead took on the feminine attributes that are familiar in the West’s consumer-oriented societies. Each chapter in the volume explores different aspects of these changes and links those changes to national security, nationalism, and relations with Western societies, while focusing on a variety of genres of expression such as films, music, plays, literature, press reports, television talk shows, and ethnographic research. The topics explored in this volume open a space for discussion and reflection about how radical social change intimately affected the lives and identities of women, and their positions in society, resulting in various policy initiatives involving women’s social and political roles.
The book will be of interest to students and scholars of gender studies, comparative politics, Eastern European studies, and cultural studies.