Mohamad Sawan - Böcker

Research and innovation in areas such as circuits, microsystems, packaging, biocompatibility, miniaturization, power supplies, remote control, reliability, and lifespan are leading to a rapid increase in the range of devices and corresponding applications in the field of wearable and implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the health conditions of the human body.

This book provides comprehensive coverage of the fundamental design principles and validation for implantable microsystems, as well as several major application areas. Each component in an implantable device is described in details, and major case studies demonstrate how these systems can be optimized for specific design objectives.

The case studies include applications of implantable neural signal processors, brain-machine interface (BMI) systems intended for both data recording and treatment, neural prosthesis, bladder pressure monitoring for treating urinary incontinence, implantable imaging devices for early detection and diagnosis of diseases as well as electrical conduction block of peripheral nerve for chronic pain management.

Implantable Biomedical Microsystems is the first comprehensive coverage of bioimplantable system design providing an invaluable information source for researchers in Biomedical, Electrical, Computer, Systems, and Mechanical Engineering as well as engineers involved in design and development of wearable and implantable bioelectronic devices and, more generally, teams working on low-power microsystems and their corresponding wireless energy and data links.

First time comprehensive coverage of system-level and component-level design and engineering aspects for implantable microsystems. Provides insight into a wide range of proven applications and application specific design trade-offs of bioimplantable systems, including several major case studies Enables Engineers involved in development of implantable electronic systems to optimize applications for specific design objectives.

This book provides a broad survey of the field of biochips, including fundamentals of microelectronics and biomaterials interaction with various, living tissues, as well as numerous, diverse applications. Although a wide variety of biochips will be described, there will be a focus on those at the brain-machine interface. Analysis is included of the relationship between different categories of biochips and their interactions with the body and coverage includes wireless remote control of biochips and arrays of microelectrodes, based on new biomaterials.

This book provides a broad survey of the field of biochips, including fundamentals of microelectronics and biomaterials interaction with various, living tissues, as well as numerous, diverse applications. Although a wide variety of biochips will be described, there will be a focus on those at the brain-machine interface. Analysis is included of the relationship between different categories of biochips and their interactions with the body and coverage includes wireless remote control of biochips and arrays of microelectrodes, based on new biomaterials.

This book provides design-oriented models for the implementation of ultra-low-voltage energy harvesting converters, covering the modeling of building blocks such oscillators, rectifiers, charge pumps and inductor-based converters that can operate with very low supply voltages, typically under 100 mV. Analyses based on the diode and MOSFET models are included in the text to allow the operation of energy harvesters from voltages of the order of 100 mV or much less, with satisfactory power efficiency. The practical realization of different converters is also addressed, clarifying the design trade-offs of ultra-low voltage (ULV) circuits operating from few millivolts.Offers readers a state-of-the-art revision for ultra-low voltage (ULV) energy harvesting converters;Provides analog IC designers with proper models for the implementation of circuits and building blocks of energy harvesters, such as oscillators, rectifiers, and inductor-based converters, operating under ultra-low voltages;Addresses the design of energy harvesters operating from ultra-low voltages, enabling autonomous operation of connected devices driven by human energy;Demonstrates design and implementation of integrated ULV up-converters;Includes semiconductor modeling for ULV operation.

This book provides design-oriented models for the implementation of ultra-low-voltage energy harvesting converters, covering the modeling of building blocks such oscillators, rectifiers, charge pumps and inductor-based converters that can operate with very low supply voltages, typically under 100 mV. Analyses based on the diode and MOSFET models are included in the text to allow the operation of energy harvesters from voltages of the order of 100 mV or much less, with satisfactory power efficiency. The practical realization of different converters is also addressed, clarifying the design trade-offs of ultra-low voltage (ULV) circuits operating from few millivolts.Offers readers a state-of-the-art revision for ultra-low voltage (ULV) energy harvesting converters;Provides analog IC designers with proper models for the implementation of circuits and building blocks of energy harvesters, such as oscillators, rectifiers, and inductor-based converters, operating under ultra-low voltages;Addresses the design of energy harvesters operating from ultra-low voltages, enabling autonomous operation of connected devices driven by human energy;Demonstrates design and implementation of integrated ULV up-converters;Includes semiconductor modeling for ULV operation.

1.1 Overview of Lab-on-Chip Laboratory-on-Chip (LoC) is a multidisciplinary approach used for the miniaturization, integration and automation of biological assays or procedures in analytical chemistry [1–3]. Biology and chemistry are experimental sciences that are continuing to evolve and develop new protocols. Each protocol offers step-by-step laboratory instructions, lists of the necessary equipments and required biological and/or chemical substances [4–7]. A biological or chemical laboratory contains various pieces of equipment used for performing such protocols and, as shown in Fig. 1.1, the engineering aspect of LoC design is aiming to embed all these components in a single chip for single-purpose applications. 1.1.1 Main Objectives of LoC Systems Several clear advantages of this technology over conventional approaches, including portability, full automation, ease of operation, low sample consumption and fast assays time, make LoC suitable for many applications including. 1.1.1.1 Highly Throughput Screening To conduct an experiment, a researcher fills a well with the required biological or chemical analytes and keeps the sample in an incubator for some time to allowing the sample to react properly. Afterwards, any changes can be observed using a microscope. In order to quickly conduct millions of biochemical or pharmacolo- cal tests, the researchers will require an automated highly throughput screening (HTS) [8], comprised of a large array of wells, liquid handling devices (e.g., mic- channel, micropump and microvalves [9–11]), a fully controllable incubator and an integrated sensor array, along with the appropriate readout system.