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Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic offers an advanced exploration into the comprehensive understanding of disease etiology and prognosis through multiomics approaches. This authoritative volume delves into the applications of multiomics technology in elucidating complex human health conditions and diseases. It introduces the technology's potential for biomarker identification, drug discovery, and disease prognostication. For a thorough understanding of human health and diseases, particularly cancer, it is essential to integrate knowledge of molecular biomarkers across multiple omics levels, including the genome, epigenome, transcriptome, proteome, and metabolome. This resource addresses the current gaps in knowledge among students and researchers, providing in-depth coverage of multiomics technology and its implementation in scientific research and discovery.Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omics is a pioneering resource that presents cutting-edge information on contemporary multiomics technologies for big data interpretation and their applications in deciphering complex human pathobiology. This comprehensive guide is indispensable for researchers, academics, students, and industry professionals alike.Presents the most recent advancements in multiomics technology for elucidating complex human pathobiology.Offers comprehensive insights into understanding disease etiology and prognosis.Introduces the principles of multiomics technology and its applications in biomarker identification, drug discovery, and disease prognostication.Explores the tools and methodologies for integrating and interpreting multiomics data sets.Introduces multiomics databases and visualization web portals.Provides up-to-date information on the role of multiomics technology in understanding intricate human pathobiology.

Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic provides a way forward in understanding complete disease etiology and prognosis. This unique book gives a comprehensive understanding of multi-omics technology and its applications in understanding complex human health and disease and not only introduces the technology, but also its use for biomarker identification, drug discovery, and disease prognostication. A comprehensive understanding of human health and diseases, particularly cancer, requires knowledge of molecular biomarkers at a multi-omics level, including genome, epigenome, transcriptome, proteome, and metabolome, which is meagerly available or highly lacking among the students and scientific researchers. This book covers all the aspects of multi-omics technology and how this technology can be implemented into scientific research and discovery.Multi-Omics Technology in Human Health and Diseases: Genomics, Epigenomics, Transcriptomics, Proteomics, Metabolomics, Radiomics, Multi-omic is the first resource to present the latest information on currently utilized multi-omics technology for big data interpretation and their applications in understanding the complex human pathobiology. This is the perfect resource for researchers, academia, students, as well as the industrial audience.- Presents the most recent advancements in multiomics technology for elucidating complex human pathobiology.- Offers comprehensive insights into understanding disease etiology and prognosis.- Introduces the principles of multiomics technology and its applications in biomarker identification, drug discovery, and disease prognostication.- Explores the tools and methodologies for integrating and interpreting multiomics data sets.- Introduces multiomics databases and visualization web portals.- Provides up-to-date information on the role of multiomics technology in understanding intricate human pathobiology.

This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.

This book Alternative Splicing and Cancer explores the crucial role alternative splicing, a post-transcriptional process, plays in human health and diseases, particularly cancer. Diving deep into the complexities of gene expression and protein diversity, the book illuminates how abnormal splicing contributes to aggressive tumor formation, affecting cellular functions such as proliferation, survival, and immune evasion. With a focus on understanding molecular mechanisms, this book unravels potential diagnostic and prognostic targets, opening doors for enhanced anti-cancer treatment efficacy. An indispensable resource for anyone intrigued by the interplay between gene splicing and cancer biology, it paves the way towards innovative therapeutic strategies.

This book discusses current concepts and future translational possibilities of Artificial Intelligence (AI) in human healthcare and diseases. The initial chapter reviews the application and integration of AI and multi-omics to develop novel diagnostic and therapeutic strategies. The book chapter also explores the recent advances in data-driven approaches that aided state-of-the-art AI for biomarker discovery and better disease diagnosis. The book also offers computational and oncological prospects for the role of AI in radio genomics, as well as its offers, achievements, opportunities, and limitations in the current clinical practices. The chapters further cover the role of the current state of AI in Cardiovascular Disease, Obesity and Diabetes, Neurological Diseases, and Infectious Diseases. Towards the end, the book highlights the use of AI in diverse pharmaceutical industry sectors, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. This book is handy for basic, translational, clinical & interdisciplinary researchers and bioinformaticians.

This book discusses current concepts and future translational possibilities of Artificial Intelligence (AI) in human healthcare and diseases. The initial chapter reviews the application and integration of AI and multi-omics to develop novel diagnostic and therapeutic strategies. The book chapter also explores the recent advances in data-driven approaches that aided state-of-the-art AI for biomarker discovery and better disease diagnosis. The book also offers computational and oncological prospects for the role of AI in radio genomics, as well as its offers, achievements, opportunities, and limitations in the current clinical practices. The chapters further cover the role of the current state of AI in Cardiovascular Disease, Obesity and Diabetes, Neurological Diseases, and Infectious Diseases. Towards the end, the book highlights the use of AI in diverse pharmaceutical industry sectors, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. This book is handy for basic, translational, clinical & interdisciplinary researchers and bioinformaticians.

This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.

This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.