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The International Conference on Fracture Mechanics Technology Applied to Material Evaluation and Structure Design was held in Melbourne, Australia, from August 10 to 13, 1982. It was sponsored jointly by the Australian Fracture Group and Institute of Fracture and Solid Mechanics at Lehigh University. Pro fessor G. C. Sih of Lehigh University, Drs. N. E. Ryan and R. Jones of Aeronau tical Research Laboratories served as Co-Chairmen. They initiated the organiza tion of this international event to provide an opportunity for the practitioners, engineers and interested individuals to present and discuss recent advances in the evaluation of material and structure damage originating from defects or cracks. Particular emphases were placed on applying the fracture mechanics tech nology for assessing interactions between material properties, design and opera tional requirements. It is timely to hold such a Conference in Australia as she embarks on technology extensive industries where safeguarding structures from pre mature and unexpected failure is essential from both the technical and economical points. view The application of system-type approach to failure control owes much of its success to fracture mechanics. It is now generally accepted that the discipline, when properly implemented, provides a sound engineering basis for accounting in teractions between material properties, design, fabrication, inspection and op erational requirements. The approach offers effective solutions for design and maintenance of large-scale energy generation plants, mining machineries, oil ex ploration and retrieval equipments, land, sea and air transport vehicles.
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Neovascularization isanormalphaseoftissue repair mechanlsm. In theeye, however, sproutingofnewvessels withinavasculartissuesandtheirgreatertendencytobleed havedetrimentaleffectsonvision. Diabeticretinopathy, corneal neovascularization, age-related macular degeneration, retinal veinocclusion, andretinopathy of prematurity are major causes of blindness. In all, uncontrolled proliferationofnewvesselsistheunderlying pathologicalcauseleadingtotheinexorablelossofvision. Development of lasertechnologiesandtheir wide use in ophthalmology have broughtsomehopeforthetreqtment of these diseases. However,itbecameevident that direct closureofthenewvesselsand/orablationoflargepartsof thetissuearenotidealsolutionstotheproblem. Recent advances in molecular biology and genetic engineering have fosteredbasic knowledge regarding the growth factors and intercellular messengers and their association with theproliferationofnew blood vessels. These latter findings sparked a renewed interest in Michaelson's "X-factor" ofocular neovascularization and opened avenues for possible innovative therapeutic approaches.Therefore, the suggestion to organize an international gathering of clinicians and scientists interested in problems of ocular circulation and neovascularization was received with great enthusiasm. Unanimously,it wasdecidedtodedicatethe symposium to Professor I.C. Michaelson, theinnovativescientist, the greatclinician, theindefatigableteacher, andaboveall, thewonderfulhumanbeing. The meeting was highlighted by the outstanding atmosphere of friendshipandscientif*ic exchanges. This book mirrors the information delivered and includes a selectionofpapersfromthescientificprogram. Theorganizationofthismeetingandthepublicationof thebookwouldnothavebeenpossiblewithouttheharmonious teameffortsmadebytheInternational,ScientificandLocal Committees. I am thankful tothe chairpersons of the varioussessionsfortheirtime, keeninterestandendeavor for the realizationofahighscientific level. I also deeplyacknowledgethehelpand&upportofArnallPatz, Bob Murphy, BertGlaser,RobertFrank,LarryHjelmeland,Gordon Klintworth, Neville Welsh, Charles Riva, Alec Garner, DesmondArcher,EphraimFriedman,MyronYanoff,MosheLahav, Willem Manschot, Hans-WaltherLarsenand Masanobu Uyama.The powerful stimulus of Hanan Zauberman, Steve Ryan, GabrielCoscas, GiselleSoubrane, MosheIvry,YuvalYassur and Sue and Peter Ballenwasmost instrumental in the realizationofthese"dreams". Asalways, Iwasfortunate tohavetheinvaluablecollaborationofmyloyalassistants: Evelyne Cohen, Genia Maftzir, Israel Barzel, Arieh Zelikovitch, andJudithBenEzra. Thesmoothrunningofthe meeting andtimelyeditingofthebookcouldnothave been possible without theincalculablehelp and indefatigable typing and councilofJudithFisher, whoseconded me in selectingthepapersandeditingthebook.