Neil D. Rawlings – författare

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more.- The only comprehensive book on proteolytic enzymes- Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research- Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases- Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features- Over 1000 peptidases included

The Handbook of Proteolytic Enzymes, Fourth Edition is the latest release in this esteemed publication that stands as the most comprehensive work in applied enzymology and biocatalysis since the first edition published in 1998. Extensively updated, the new edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.Provides the only comprehensive book on serine and threonine peptidases, with over 400 peptides includedWritten by experts in their field, including updates on proteolytic enzymes from all groups of living organisms and viruses, and some that are major targets of pharmaceutical researchPresents a fully searchable text, with 2D and 3D structures of peptidases in color and links to PubMed and MEROPS databasesDetails the latest proteotases used in therapeutic research and discusses recent drug trials

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Four: Aspartic and Glutamic Peptidases, Asparagine Peptide Lyases and Peptidases of Unknown Catalytic Mechanisms includes over 250 chapters on known aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanisms. Chapters discuss each enzyme’s name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.Edited by world-renowned experts, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Provides a comprehensive book on aspartic and glutamic peptidases, asparagine peptide lysases, and peptidases of unknown catalytic mechanismsWritten by experts on proteolytic enzymes from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical researchPresents fully searchable text and color 2D and 3D structures of peptidases, with direct links to PubMed and MEROPS databasesDetails the latest proteotases used in therapeutic research and discusses recent drug trials

Handbook of Proteolytic Enzymes: Cysteine Peptidases, Fourth Edition?is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. It includes over 300 chapters on known cysteine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of peptidases, extensive references, and links to PubMed and MEROPS databases.Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Provides a comprehensive book on cysteine peptidases, with over 300 peptides includedWritten by experts in their field, and covering proteolytic enzymes from all groups of living organisms and virusesIncludes candidates that are currently major targets of pharmaceutical researchPresents a fully searchable text, color 2D and 3D structures of peptidases, and direct links to PubMed and MEROPS databasesDetails the latest proteotases used in therapeutic research and discusses recent drug trials

Handbook of Proteolytic Enzymes, Fourth Edition, Volume Five: Inhibitors of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. This volume offers a thorough discussion of known naturally-occurring and synthetic inhibitors of proteolytic enzymes. Each chapter includes enzyme inhibitor names, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with color 2D and 3D structures of inhibitors, extensive references, and links to PubMed and MEROPS databases.Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

Provides a comprehensive book on naturally-occurring and synthetic inhibitors of proteolytic enzymesWritten by experts in their field, and covering proteolytic enzymes from all groups of living organisms and virusesIncludes candidates that are currently major targets of pharmaceutical researchPresents a fully searchable text, color 2D and 3D structures of peptidases, and direct links to PubMed and MEROPS databasesDetails the latest proteotases used in therapeutic research and discusses recent drug trials

Handbook of Proteolytic Enzymes: Metallopeptidases, Fourth Edition has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume, Metallopeptidases, includes over 300 chapters on known metallopeptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Handbook of Proteolytic Enzymes, Metallopeptidases has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume includes over 300 chapters on known metallopeptidases enzymes, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.