Handbook of Proteolytic Enzymes

Serine and Threonine Peptidases

AvNeil D. Rawlings

Häftad, Engelska, 2026

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Beskrivning

The Handbook of Proteolytic Enzymes, Fourth Edition is the latest release in this esteemed publication that stands as the most comprehensive work in applied enzymology and biocatalysis since the first edition published in 1998. Extensively updated, the new edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field, and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.

This volume includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Provides the only comprehensive book on serine and threonine peptidases, with over 400 peptides included
Written by experts in their field, including updates on proteolytic enzymes from all groups of living organisms and viruses, and some that are major targets of pharmaceutical research
Presents a fully searchable text, with 2D and 3D structures of peptidases in color and links to PubMed and MEROPS databases
Details the latest proteotases used in therapeutic research and discusses recent drug trials

Produktinformation

Utgivningsdatum:2026-09-01
Mått:191 x 235 x undefined mm
Format:Häftad
Språk:Engelska
Antal sidor:808
Upplaga:4
Förlag:Elsevier Science
ISBN:9780128225738

Utforska kategorier

Tillämpad fysik inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik

Mer om författaren

Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science.

Innehållsförteckning

New Chapters1. Transmembrane Peptidase, Serine 42. Mesotrypsin3. Kallikrein-Related Peptidase 64. Arginyl Peptidase5. HtrA Peptidase (Helicobacter)6. HtrA Peptidase (Borrelia burgdorferi)7. Zika Virus NS2B-NS3 Peptidase8. Keratinase K1 (Stenotrophomonas maltophilia)9. Mycosin-110. Dipeptidylpeptidase Homologue DPP611. ClpP1 Peptidase (Streptomyces)12. ClpP2 Peptidase (Streptomyces)Major Revisions13. Chymotrypsin A (Cattle-Type)14. Granzyme B (Homo sapiens-Type)15. Tryptase Beta16. Kallikrein-Related Peptidase 317. Kallikrein-Related Peptidase 518. Kallikrein-Related Peptidase 719. Corin20. Factor VII-Activating Peptidase21. Trypsin 122. Cationic Trypsin (Homo sapiens-Type)23. Elastase-224. Cathepsin G25. Myeloblastin26. Chymase (Homo sapiens-Type)27. Prostasin28. Mesotrypsin29. Coagulation Factor VIIa30. Coagulation Factor IXa31. Coagulation Factor Xa32. Coagulation Factor XIa33. Coagulation Factor XIIa34. Thrombin35. Plasma Kallikrein36. Urokinase-Type Plasminogen Activator37. t-Plasminogen Activator38. Plasmin39. Hepsin40. Epitheliasin41. Matriptase42. Matriptase-243. HtrA1 Peptidase (Homo sapiens-Type)44. HtrA2 Peptidase45. Flavivirin46. Hepacivirin47. Bacterial Proteasome, Beta Component48. Proteasome Subunit Beta1c49. Proteasome Subunit Beta2c50. Proteasome Subunit Beta5c51. Proteasome Subunit Beta1i52. Proteasome Subunit Beta5i53. Taspase-154. Subtilisin Carlsberg55. PfSUB1 Peptidase56. PCSK1 Peptidase57. PCSK9 Peptidase58. Site-1 Peptidase59. Furin60. Tripeptidyl-Peptidase I61. Prolyl Oligopeptidase62. Dipeptidyl-Peptidase IV (Eukaryote)63. Fibroblast Activation Protein Alpha Subunit64. Dipeptidyl-Peptidase 965. Serine Carboxypeptidase A66. Lysosomal Pro-Xaa Carboxypeptidase67. Signal Peptidase I68. Lon-A Peptidase69. PIM1 Peptidase70. Peptidase Clp (Type 1)

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