Nick Lane – författare

'One of my favourite science writers' Bill Gates'Hugely important' Jim Al-Khalili'A profound meditation on metabolism, the Krebs cycle & the origin of life' Anil SethFor decades, biology has been dominated by information - the power of genes. Yet there is no difference in information content between a living cell and one that died a moment ago. A better question goes back to the formative years of biology: what processes animate cells and set them apart from lifeless matter?In Transformer, Nick Lane turns the standard view upside down, capturing an extraordinary scientific renaissance that is hiding in plain sight. At its core is an amazing cycle of reactions that uses energy to transform inorganic molecules into the building blocks of life - and the reverse. To understand this cycle is to fathom the deep coherence of the living world. It connects the origin of life with the devastation of cancer, the first photosynthetic bacteria with our own mitochondria, sulphurous sludges with the emergence of consciousness, and the trivial differences between ourselves with the large-scale history of our planet.

Oxygen has had extraordinary effects on life. Three hundred million years ago, in Carboniferous times, dragonflies grew as big as seagulls, with wingspans ofnearly a metre. Researchers claim they could have flown only if the air had contained more oxygen than today -probably as much as 35 per cent. Giant spiders, tree-ferns, marine rock formations and fossil charcoalsall tell the same story. High oxygen levels may also explain the global firestorm that contributed to thedemise of the dinosaurs after the asteroid impact. The strange and profound effects that oxygen has had on the evolution of life pose a riddle, which this booksets out to answer. Oxygen is a toxic gas. Divers breathing pure oxygen at depth suffer from convulsionsand lung injury. Fruit flies raised at twice normal atmospheric levels of oxygen live half as long as theirsiblings. Reactive forms of oxygen, known as free radicals, are thought to cause ageing in people. Yet ifatmospheric oxygen reached 35 per cent in the Carboniferous, why did it promote exuberant growth,instead of rapid ageing and death? Oxygen takes the reader on an enthralling journey, as gripping as a thriller, as it unravels the unexpectedways in which oxygen spurred the evolution of life and death. The book explains far more than the size ofancient insects: it shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated ageing of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths,explaining modern killer diseases, why we age, and what we can do about it. Advancing revelatory new ideas,following chains of evidence, the book ranges through many disciplines, from environmental sciences tomolecular medicine. The result is a captivating vision of contemporary science and a humane synthesis of ourplace in nature. This remarkable book might just redefine the way we think about the world.Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.

While it is barely 50 years since the first reliable reports of the recovery of living cells frozen to cryogenic temperatures, there has been tremendous growth in the use of cryobiology in medicine, agriculture, horticulture, forestry, and the conservation of endangered or economically important species.As the first major text on cryobiology in the genomic era, Life in the Frozen State describes the current understanding of how living cells and complex organisms survive very low temperatures. Leading world experts combine fundamental theory and practice across a spectrum of species and applications to evaluate how cryobiology can benefit humanity. Chapters encompass disciplines ranging from mathematical modeling and biophysics, to the molecular biology of stress gene expression and the clinical banking of cells and tissues.This book provides a unique opportunity to explore the subject in a multidisciplinary context, which has historically been the key to realizing some of the most exciting advances in low temperature research.FeaturesIntegrates fundamental theory and practice across a broad range of species and applications Discusses cryobiology within a multidisciplinary context Emphasizes how the current knowledge of cryobiology can be applied to benefit humanity through health care and conservation

Where does DNA come from? What is consciousness? How did the eye evolve? Drawing on a treasure trove of new scientific knowledge, Nick Lane expertly reconstructs evolution’s history by describing its ten greatest inventions—from sex and warmth to death—resulting in a stunning account of nature’s ingenuity.

While it is barely 50 years since the first reliable reports of the recovery of living cells frozen to cryogenic temperatures, there has been tremendous growth in the use of cryobiology in medicine, agriculture, horticulture, forestry, and the conservation of endangered or economically important species.As the first major text on cryobiology in the genomic era, Life in the Frozen State describes the current understanding of how living cells and complex organisms survive very low temperatures. Leading world experts combine fundamental theory and practice across a spectrum of species and applications to evaluate how cryobiology can benefit humanity. Chapters encompass disciplines ranging from mathematical modeling and biophysics, to the molecular biology of stress gene expression and the clinical banking of cells and tissues.This book provides a unique opportunity to explore the subject in a multidisciplinary context, which has historically been the key to realizing some of the most exciting advances in low temperature research.FeaturesIntegrates fundamental theory and practice across a broad range of species and applications Discusses cryobiology within a multidisciplinary context Emphasizes how the current knowledge of cryobiology can be applied to benefit humanity through health care and conservation

Why is life the way it is? Bacteria evolved into complex life just once in four billion years of life on earth-and all complex life shares many strange properties, from sex to ageing and death. If life evolved on other planets, would it be the same or completely different?In The Vital Question, Nick Lane radically reframes evolutionary history, putting forward a cogent solution to conundrums that have troubled scientists for decades. The answer, he argues, lies in energy: how all life on Earth lives off a voltage with the strength of a bolt of lightning. In unravelling these scientific enigmas, making sense of life's quirks, Lane's explanation provides a solution to life's vital questions: why are we as we are, and why are we here at all?This is ground-breaking science in an accessible form, in the tradition of Charles Darwin's The Origin of Species, Richard Dawkins' The Selfish Gene, and Jared Diamond's Guns, Germs and Steel.

'One of my favourite science writers' Bill GatesFor decades, biology has been dominated by information - the power of genes. Yet in terms of information there is no difference between a living cell and one that died a moment ago. What really animates cells and sets them apart from non-living matter? This question goes back to the flawed geniuses and heroic origins of modern biology. The answer could turn our picture of life on Earth upside down.In Transformer, Nick Lane captures a scientific renaissance that is hiding in plain sight. At its core is a cycle of reactions that transforms inorganic molecules into the building blocks of life, and the reverse - the iconic Krebs cycle that sits at the heart of metabolism. This conflicted merry-go-round of energy and matter has long taunted true understanding. Nick Lane is in the vanguard of scientists now tracing its ramifications across the tree of life. To grasp the Krebs cycle is to fathom the deep coherence of biology. It connects the first photosynthetic bacteria with our own peculiar cells. It links the emergence of consciousness with the inevitability of death. And it puts the subtle differences between individuals in the same grand story as the rise of the living world itself.Life is at root a chemical phenomenon: this is its deep logic.

Winner of the 2010 Royal Society Prize for science booksPowerful new research methods are providing fresh and vivid insights into the makeup of life. Comparing gene sequences, examining the atomic structure of proteins and looking into the geochemistry of rocks have all helped to explain creation and evolution in more detail than ever before. Nick Lane uses the full extent of this new knowledge to describe the ten greatest inventions of life, based on their historical impact, role in living organisms today and relevance to current controversies. DNA, sex, sight and consciousnesses are just four examples.Lane also explains how these findings have come about, and the extent to which they can be relied upon. The result is a gripping and lucid account of the ingenuity of nature, and a book which is essential reading for anyone who has ever questioned the science behind the glories of everyday life.