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1 646 kr
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This is a study based on the proceedings of a workshop concerned with extracellular virulence factors of mucoid strains of Pseudomonas aeruginosa in relation to Cystic Fibrosis. It is intended to further the understanding of mucoid P. aeruginosa infections and to provide benefit to those who need it most - the children and adults suffering from CF. It focuses on alginate as an extracellular virulence factor of P.aeruginosa in CF pulmonary infections and presents advances in the biochemistry and molecular genetics of alginate biosynthesis and the basic defect in CF and isolation of the gene. The non-mucoid to mucoid transformation "in vitro" and "in vivo" are discussed in relation to host responses to alginate. The structure, properties, and biosynthesis including genetics of alginate are dealt with in detail and related to its chemical physical and biological properties.
503 kr
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Die Entwicklung der Immobilisierungstechniken für Enzyme seit den 50er Jahren hat zu einem Boom bei der industriellen Anwendung von Enzymen geführt und hat an Wissenschaftler mit verschiedenstem akademischen Hintergrund die Anforderung gestellt, in der Enzymtechnologie zu arbeiten. Dieses Buch wendet sich an Studenten sowie in der Industrie tätige Wissenschaftler, die aus den Fachbereichen Chemieingenieurwesen, Chemie, Biochemie, Mikrobiologie/Biologie, Technische Biologie sowie Biotechnologie kommen und ein allgemeines Interesse an Enzymen haben. Es bringt dem Ingenieur die Feinheiten der Enzyme sowie das Potential der Techniken in der Molekulargenetik nahe, mit denen diese Katalysatoren für spezifische Anwendungen geschneidert werden können. Für jene mit einem chemisch/biochemischen oder biologischen Hintergrund werden in diesem Buch vor allem die biochemisch-technischen Beschreibungen, wie kinetische Eigenschaften und Reaktorkonstruktion, von Nutzen sein.
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The concept of this book arose out of an international workshop, which we organized and held at the University of Wales Conference Centre at Gregynog. The workshop was the first occasion on which researchers from all the different disciplines concerned with the extracellular virulence factors of mucoid strains of Pseudomonas aeruginosa in relation to cystic fibrosis (CF) had met to discuss this multifaceted problem. It was deemed a particularly timely moment to gather together experts for the exchange of facts, ideas and hypotheses. No formal abstracts were presented and no proceedings were published. But during the succeed ing months the organizers were persuaded by a number of participants that a wider audience should benefit from what had proved to be such a fruitful cross-fertilization of expertise. Thus we moved from being workshop organizers to book editors, sure in the knowledge that at least we had a willing and enthusiastic set of contributors! It should be stressed, however, that this book is not a transcript of that workshop. Not all those participants are authors, and some new names have been added. Instead we have focused on alginate as an extracellular virulence factor of P. aeruginosa in CF pulmonary infections. Recent advances in the biochemistry and molecular genetics of alginate bio synthesis, as well as in our understanding of the basic defect in CF and isolation of the gene, mean that the book is even more timely than when first planned.